LEI WANG1,2, ZHI-HANG WANG1, NIAN-PING CAO1, BOBO CHEN1, CHONG-JUN HUANG1, LEI YANG1, YE TIAN1,*
BIOCELL, Vol.48, No.2, pp. 191-203, 2024, DOI:10.32604/biocell.2023.045349
Abstract Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms. ERRα is also related to the onset and progression of various cancer types. ERRα is primarily expressed in metabolically active tissues and regulates the transcription of metabolic genes in such tissues. It coordinates metabolism and energy demand, affects osteoblasts, osteoclasts, and chondrocytes, promotes muscle regeneration, participates in angiogenesis, and regulates cell aging. In this study, the literature related to the identification of ERRα in skeletal, muscular, and vascular systems was reviewed to further elucidate this receptor. More >
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