QI SONG1, JUN ZHANG1, QIANG ZHANG1, JING LIU1, KE LV1, JIALU YAO1,2,3,*, YAFENG ZHOU2,3,*
BIOCELL, Vol.44, No.4, pp. 623-629, 2020, DOI:10.32604/biocell.2020.012645
Abstract Macrophages play an essential role in the myocardial ischemia-reperfusion injury (MIRI), and the macrophage
shifting from M1 to M2 phenotypes might be a potential strategy for the treatment of MIRI. It has been reported that
miR-182 plays an important role in MSC-Exo-associated macrophage polarization. As circBCRC-3 is a newly
discovered circle RNA that worked as a sponge of miR-182, this research aimed to find if circBCRC-3 plays a role in
MSC-Exo-associated macrophage polarization. Firstly, circBCRC-3 was identified by divergent primers in
mesenchymal stem cells (MSCs). Secondly, the exosome of MSCs was isolated and identified by transmission electron
microscopy (TEM), nanoparticle-tracking… More >
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