Manaliben Amin^*

Journal on Artificial Intelligence, Vol.8, pp. 1-18, 2026, DOI:10.32604/jai.2026.073895 - 07 January 2026

Abstract Artificial intelligence (AI) is steadily making its way into pharmaceutical validation, where it promises faster documentation, smarter testing strategies, and better handling of deviations. These gains are attractive, but in a regulated environment speed is never enough. Regulators want assurance that every system is reliable, that decisions are explainable, and that human accountability remains central. This paper sets out a Human-in-the-Loop (HITL) AI approach for Computer System Validation (CSV) and Computer Software Assurance (CSA). It relies on explainable AI (XAI) tools but keeps structured human review in place, so automation can be used without creating… More >

Jaeho Shin¹, Jaekwang Kim^2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-26, 2026, DOI:10.32604/cmc.2025.068767 - 10 November 2025

Abstract Network attacks have become a critical issue in the internet security domain. Artificial intelligence technology-based detection methodologies have attracted attention; however, recent studies have struggled to adapt to changing attack patterns and complex network environments. In addition, it is difficult to explain the detection results logically using artificial intelligence. We propose a method for classifying network attacks using graph models to explain the detection results. First, we reconstruct the network packet data into a graphical structure. We then use a graph model to predict network attacks using edge classification. To explain the prediction results, we… More >

Omar Darwish¹, Shorouq Al-Eidi², Abdallah Al-Shorman¹, Majdi Maabreh³, Anas Alsobeh⁴, Plamen Zahariev⁵, Yahya Tashtoush^6,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-21, 2026, DOI:10.32604/cmc.2025.068266 - 10 November 2025

Abstract Covert timing channels (CTC) exploit network resources to establish hidden communication pathways, posing significant risks to data security and policy compliance. Therefore, detecting such hidden and dangerous threats remains one of the security challenges. This paper proposes LinguTimeX, a new framework that combines natural language processing with artificial intelligence, along with explainable Artificial Intelligence (AI) not only to detect CTC but also to provide insights into the decision process. LinguTimeX performs multidimensional feature extraction by fusing linguistic attributes with temporal network patterns to identify covert channels precisely. LinguTimeX demonstrates strong effectiveness in detecting CTC across… More >

MD Hamid Borkot Tulla^1,*, MD Moniur Rahman Ratan², Rashid MD Mamunur³, Abdullah Hil Safi Sohan⁴, MD Matiur Rahman⁵

Journal of Cyber Security, Vol.7, pp. 675-691, 2025, DOI:10.32604/jcs.2025.074737 - 24 December 2025

Abstract Phishing is considered one of the most widespread cybercrimes due to the fact that it combines both technical and human vulnerabilities with the intention of stealing sensitive information. Traditional blacklist and heuristic-based defenses fail to detect such emerging attack patterns; hence, intelligent and transparent detection systems are needed. This paper proposes an explainable machine learning framework that integrates predictive performance with regulatory accountability. Four models were trained and tested on a balanced dataset of 10,000 URLs, comprising 5000 phishing and 5000 legitimate samples, each characterized by 48 lexical and content-based features: Decision Tree, XGBoost, Logistic… More >

Khulud Salem Alshudukhi^1,*, Sijjad Ali², Mamoona Humayun^3,*, Omar Alruwaili⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3029-3085, 2025, DOI:10.32604/cmes.2025.073705 - 23 December 2025

Abstract Problem: The integration of Artificial Intelligence (AI) into cybersecurity, while enhancing threat detection, is hampered by the “black box” nature of complex models, eroding trust, accountability, and regulatory compliance. Explainable AI (XAI) aims to resolve this opacity but introduces a critical new vulnerability: the adversarial exploitation of model explanations themselves. Gap: Current research lacks a comprehensive synthesis of this dual role of XAI in cybersecurity—as both a tool for transparency and a potential attack vector. There is a pressing need to systematically analyze the trade-offs between interpretability and security, evaluate defense mechanisms, and outline a… More >

Mubashir Ali^1,2, Jingzhen Li¹, Zedong Nie^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4153-4177, 2025, DOI:10.32604/cmes.2025.073048 - 23 December 2025

Abstract Diabetes imposes a substantial burden on global healthcare systems. Worldwide, nearly half of individuals with diabetes remain undiagnosed, while conventional diagnostic techniques are often invasive, painful, and expensive. In this study, we propose a noninvasive approach for diabetes detection using photoplethysmography (PPG), which is widely integrated into modern wearable devices. First, we derived velocity plethysmography (VPG) and acceleration plethysmography (APG) signals from PPG to construct multi-channel waveform representations. Second, we introduced a novel multiset spatiotemporal feature fusion framework that integrates hand-crafted temporal, statistical, and nonlinear features with recursive feature elimination and deep feature extraction using… More >

Deema Alzamil^1,2,*, Bader Alkhamees², Mohammad Mehedi Hassan^2,3

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 2971-3027, 2025, DOI:10.32604/cmes.2025.070867 - 23 December 2025

Abstract Breast cancer diagnosis relies heavily on many kinds of information from diverse sources—like mammogram images, ultrasound scans, patient records, and genetic tests—but most AI tools look at only one of these at a time, which limits their ability to produce accurate and comprehensive decisions. In recent years, multimodal learning has emerged, enabling the integration of heterogeneous data to improve performance and diagnostic accuracy. However, doctors cannot always see how or why these AI tools make their choices, which is a significant bottleneck in their reliability, along with adoption in clinical settings. Hence, people are adding… More >

Abd Rahman Wahid^*

Journal of Cyber Security, Vol.7, pp. 589-614, 2025, DOI:10.32604/jcs.2025.071622 - 11 December 2025

Abstract The rapid increase in cyber attacks requires accurate, adaptive, and interpretable detection and response mechanisms. Conventional security solutions remain fragmented, leaving gaps that attackers can exploit. This study introduces the HI-XDR (Hybrid Intelligent Extended Detection and Response) framework, which combines network-based Suricata rules and endpoint-based Wazuh rules into a unified dataset containing 45,705 entries encoded into 1058 features. A semantic-aware autoencoder-based anomaly detection module is trained and strengthened through adversarial learning using Projected Gradient Descent, achieving a minimum mean squared error of 0.0015 and detecting 458 anomaly rules at the 99th percentile threshold. A comparative… More >

Farhad Mortezapour Shiri^*, Thinagaran Perumal, Norwati Mustapha, Raihani Mohamed

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 1389-1485, 2025, DOI:10.32604/cmes.2025.071858 - 26 November 2025

Abstract Human Activity Recognition (HAR) represents a rapidly advancing research domain, propelled by continuous developments in sensor technologies and the Internet of Things (IoT). Deep learning has become the dominant paradigm in sensor-based HAR systems, offering significant advantages over traditional machine learning methods by eliminating manual feature extraction, enhancing recognition accuracy for complex activities, and enabling the exploitation of unlabeled data through generative models. This paper provides a comprehensive review of recent advancements and emerging trends in deep learning models developed for sensor-based human activity recognition (HAR) systems. We begin with an overview of fundamental HAR… More > Graphic Abstract

Ngoc-Hoang-Quyen Nguyen¹, Thanh-Tung Nguyen², Anh-Cang Phan^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2435-2456, 2025, DOI:10.32604/cmes.2025.070419 - 26 November 2025

Abstract Blood cell disorders are among the leading causes of serious diseases such as leukemia, anemia, blood clotting disorders, and immune-related conditions. The global incidence of hematological diseases is increasing, affecting both children and adults. In clinical practice, blood smear analysis is still largely performed manually, relying heavily on the experience and expertise of laboratory technicians or hematologists. This manual process introduces risks of diagnostic errors, especially in cases with rare or morphologically ambiguous cells. The situation is more critical in developing countries, where there is a shortage of specialized medical personnel and limited access to… More > Graphic Abstract