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    miR-26b Mimic Inhibits Glioma Proliferation In Vitro and In Vivo Suppressing COX-2 Expression

    Zheng-Gang Chen*, Chuan-Yi Zheng*, Wang-Qing Cai, Da-Wei Li*, Fu-Yue Ye*, Jian Zhou*, Ran Wu*, Kun Yang*

    Oncology Research, Vol.27, No.2, pp. 147-155, 2019, DOI:10.3727/096504017X15021536183517

    Abstract Glioma is the most common malignant tumor of the nervous system. Studies have shown the microRNA-26b (miR-26b)/cyclooxygenase-2 (COX-2) axis in the development and progression in many tumor cells. Our study aims to investigate the effect and mechanism of the miR-26b/COX-2 axis in glioma. Decreased expression of miR-26b with increased levels of COX-2 was found in glioma tissues compared with matched normal tissues. A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. The miR-26b was then overexpressed by transfecting a miR-26b mimic into U-373 cells. The invasive cell number and wound closing rate… More >

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