Yanwen Zhu^1,#, Chen Zhao^2,#, Yishuo Xu², Zheyang Wu³, Akiko Maehara⁴, Liang Wang¹, Dirui Zhang², Ming Zeng², Rui Lv⁵, Xiaoya Guo⁶, Mengde Huang¹, Minglong Chen⁷, Gary S. Mintz⁴, Dalin Tang^1,3,*, Haibo Jia², Bo Yu^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 1249-1270, 2025, DOI:10.32604/cmes.2025.067039 - 31 August 2025

Abstract Image-based computational models have been used for vulnerable plaque progression and rupture predictions, and good results have been reported. However, mechanisms and predictions for plaque erosion are under-investigated. Patient-specific fluid-structure interaction (FSI) models based on optical coherence tomography (OCT) follow-up data from patients with plaque erosion and who received conservative antithrombotic treatment (using medication, no stenting) to identify risk factors that could be used to predict the treatment outcome. OCT and angiography data were obtained from 10 patients who received conservative antithrombotic treatment. Five participants had worse outcomes (WOG, stenosis severity ≥ 70% at one-year… More > Graphic Abstract

Liang Wang¹, Haibo Jia², Luping He², Rui Lv¹, Xiaoya Guo³, Chun Yang^4,5, Don P. Giddens^6,7, Habib Samady⁶, Akiko Maehara⁸, Gary S. Mintz⁸, Dalin Tang^1,*,5

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 23-24, 2019, DOI:10.32604/mcb.2019.07522

Abstract Plaque erosion, one of the primary causes for coronary thrombosis, is responsible for about one third of the patients with acute coronary syndrome (ACS) [1]. Histological studies characterized the eroded plaque as a plaque with following morphological features: 1) plaque intima having direct contact with intraluminal thrombus due to the absence of endothelium or endothelial injury; 2) without rupture in the fibrous cap; 3) abundance of proteoglycans and smooth muscle cells on the luminal surface under the thrombus [2]. These characteristics has been applied in in vivo diagnosis of plaque erosion using optical coherence tomography… More >