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  • Open Access

    REVIEW

    Classical biomarkers and non-coding RNAs associated with diagnosis and treatment in gastric cancer

    JINGDAN QUAN1, ZIXIN WAN1, WEI WU2, XINYUAN CAO2, JIAYUAN QIU2, XIAOYE LIU2, ZHIWEI ZHANG1,*

    Oncology Research, Vol.33, No.5, pp. 1069-1089, 2025, DOI:10.32604/or.2025.063005 - 18 April 2025

    Abstract One of the most prevalent malignant tumors worldwide, stomach cancer still has a high incidence and fatality rate in China, and the number of young people developing early-onset gastric cancer is steadily increasing. The 5-year survival rate of stomach cancer is typically 30%–35%, the prognosis is bad, the patients’ quality of life is low, and the progression of advanced gastric cancer cannot be effectively managed despite the use of surgical surgery, chemotherapy, and other medicines. We urgently need molecular biomarkers with high specificity and sensitivity to increase the early gastric cancer detection rate, extend patient… More >

  • Open Access

    ARTICLE

    A novel Wnt/β-catenin signaling gene signature for progression and metastasis of gastric cancer

    JIA CHEN1,2, FEI JIANG1, KAIYI NIU3, HAODONG ZHAO2, LI LI1,*, HONGZHU YU1,*

    Oncology Research, Vol.33, No.5, pp. 1199-1215, 2025, DOI:10.32604/or.2024.054366 - 18 April 2025

    Abstract Backgrounds: As cancer progresses through various stages of malignancy, metastasis, and drug resistance, the Wnt/-catenin signaling is frequently dysregulated. Despite advancements in medical technology and therapeutic strategies, the prognosis for numerous gastric cancer patients remains unfavorable. Methods: For the analysis of prognostic signature genes associated with Wnt signaling in GC, we used LASSO (least absolute shrinkage and selection operator) regression. To explore the function, cell specificity, and transcriptional regulation of the signature gene Carboxypeptidase Z (CPZ), we conducted co-expression analysis, single-cell RNA sequencing data analysis, transcription factor prediction, and dual luciferase reporter assay. The knockdown… More >

  • Open Access

    ARTICLE

    Epibrassinolide Induces Apoptosis and Inhibits the Migration of Gastric Cancer AGS Cells by Regulating Reactive Oxygen Species-Mediated Signaling Pathways

    Chang Wang1,2,#, Zhi Zhang1,#, Wei Sun1, Quan Quan3, Wenshuang Hou3, Chenghao Jin1,3,4,*

    BIOCELL, Vol.49, No.3, pp. 465-482, 2025, DOI:10.32604/biocell.2025.062155 - 31 March 2025

    Abstract Objectives: Epibrassinolide (EBR) is a steroid hormone with anti-tumor properties. Nevertheless, its potential to inhibit gastric cancer (GC) cells remains unknown. The aim of this research was to examine the effects of EBR on GC cells and to investigate the specific mechanism of EBR. Methods: A cell counting kit-8 (CCK-8) assay was utilized to determine cell survival rates. The investigation of apoptosis, cell cycle progression, and reactive oxygen species (ROS) levels was performed using flow cytometry. To detect cell migration, a wound-healing assay was performed on AGS cells. Furthermore, western blotting assay was utilized to determine… More >

  • Open Access

    ARTICLE

    KHSRP promotes cancer stem cell maintenance, tumorigenesis, and suppresses anti-tumor immunity in gastric cancer

    YARU DU1,2,#, ZHIHUI PEI1,3,#, SHUQIN HU4, CHUANWEN LIAO1, SHUHAO LIU1,*

    Oncology Research, Vol.33, No.2, pp. 309-325, 2025, DOI:10.32604/or.2024.058273 - 16 January 2025

    Abstract Objectives: KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein involved in several cellular processes, including nuclear splicing, mRNA localization, and cytoplasmic degradation. While KHSRP’s role has been studied in other cancers, its specific involvement in gastric cancer remains poorly understood. This study aims to explore KHSRP expression in gastric cancer and its potential effects on tumor progression and immune response. Methods: KHSRP expression in gastric cancer tissues and normal tissues was analyzed using data from The Cancer Genome Atlas (TCGA) database. The correlation between KHSRP expression, patient survival, and immune response was also assessed.… More >

  • Open Access

    REVIEW

    Immunotherapy in gastric cancer—A systematic review

    MARTA SANTOS1, DIANA MARTINS1,2,3,4, FERNANDO MENDES1,2,3,4,5,*

    Oncology Research, Vol.33, No.2, pp. 263-281, 2025, DOI:10.32604/or.2024.052207 - 16 January 2025

    Abstract Background: Gastric Cancer (GC) is the 5th most prevalent and 4th most deadly neoplasm globally. Immunotherapy has emerged as a promising treatment approach in GC, potentially improving positive clinical outcomes while addressing the limitations of conventional therapies. GC immunotherapy modalities consist of adoptive cell therapy (ACT), cancer vaccines, and immune checkpoint inhibitors (ICI). Objectives: This systematic review aims to provide an overview of the advances in immune-based therapeutic approaches in GC, highlighting the potential of this therapy as a strategy for GC treatment. Methods: Key studies investigating several immunotherapeutic agents and combination therapies were searched in… More > Graphic Abstract

    Immunotherapy in gastric cancer—A systematic review

  • Open Access

    ARTICLE

    Exosomal miR-224-3p promotes lymphangiogenesis and lymph node metastasis by targeting GSK3B in gastric cancer

    ZHENGYANG ZHOU1,#, LEI QIAO1,#, TONGTONG WANG1, WEN PAN1, JINGJING DUAN1, HAIYANG ZHANG2, TING DENG1, YI BA1,*, YI HE1,*

    Oncology Research, Vol.33, No.2, pp. 327-345, 2025, DOI:10.32604/or.2024.050431 - 16 January 2025

    Abstract Background: Patients with gastric cancer (GC) are prone to lymph node metastasis (LNM), which is an important factor for recurrence and poor prognosis of GC. Nowadays, more and more studies have confirmed that exosomes can participate in tumor lymphangiogenesis. An in-depth exploration of the pathological mechanism in the process of LNM in GC may provide effective targets and improve the diagnosis and treatment effect. Materials and Methods: We used sequencing analysis of collected serum to screen out exo-miRNA related to LNM in GC. ELISA, qRT-PCR, Western Blot, RNA pull-down assay, Transwell assay, animal experiments, and other… More > Graphic Abstract

    Exosomal miR-224-3p promotes lymphangiogenesis and lymph node metastasis by targeting GSK3B in gastric cancer

  • Open Access

    ARTICLE

    SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

    HASSAN M. OTIFI*

    Oncology Research, Vol.33, No.1, pp. 235-243, 2025, DOI:10.32604/or.2024.055677 - 20 December 2024

    Abstract Background: Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions. Methods: This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for in vitro evaluation. Results: SBL-JP-0004 exhibited a robust binding affinity for… More >

  • Open Access

    ARTICLE

    lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

    ZHOUYANG CHENG1,#, YUCHEN HUA2,#, YANG CAO3, JUN QIN1,*

    Oncology Research, Vol.33, No.1, pp. 185-198, 2025, DOI:10.32604/or.2024.042281 - 20 December 2024

    Abstract Objective: Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies. Studies have shown that the lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as a tumor promoter in various malignancies, while its function in GC has yet to be characterized. Therefore, our study aimed to explore the role and underlying mechanism of… More >

  • Open Access

    PROCEEDINGS

    Research on the Synergistic Mechanism of Photothermal-Chemotherapy-Immunotherapy of Multi-Functional Nanoparticles Against Gastric Cancer

    Erdong Shen1, Ting Pan1, Pan Guo1, Ke Chen1, Rui Xu1, Mei Yang1, Dahe Zhan1, Fang Fang1, Qinghui Wu1,*, Jianbing Hu1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-3, 2024, DOI:10.32604/icces.2024.012772

    Abstract Objective
    This study investigates the synergistic effects of a novel multifunctional nanoparticle on gastric cancer treatment through photothermal therapy, chemotherapy, and immunotherapy.

    Method
    Synthesize hollow mesoporous Prussian blue nanoparticles and load them with luteolin. Use exosomes to encapsulate the nanoparticles and modify the surface of the targeted peptide GX1. Detect the morphology of nanoparticles using a nanoparticle size analyzer and transmission electron microscopy. Use Coomassie Brilliant Blue to detect the effect of extracellular vesicle encapsulation. Detect the thermal conversion efficiency of nanoparticles under specific laser irradiation through infrared and ultraviolet spectroscopy, as well as the release rate… More >

  • Open Access

    RETRACTION

    Retraction: YEATS domain containing 4 promotes gastric cancer cell proliferation and mediates tumor progression via activating the Wnt/β-Catenin signaling pathway

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.10, pp. 1697-1698, 2024, DOI:10.32604/or.2024.056918 - 18 September 2024

    Abstract This article has no abstract. More >

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