JUNYU HE^1,2,3, FENG ZENG^1,2,3, XI JIN^1,2,3, LIN LIANG^1,2,3, MENGXIANG GAO^1,2,3, WENTAO LI^1,2,3, GUIYUAN LI^1,2,3, YANHONG ZHOU^1,2,3,*

Oncology Research, Vol.31, No.4, pp. 615-630, 2023, DOI:10.32604/or.2023.029698

Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. However, the detailed mechanism of Fra-1 in GC is unclear, such as the identification of Fra-1-interacting proteins and their role in GC pathogenesis. In this study, we identified tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH) as a Fra-1-interacting protein in GC cells using co-immunoprecipitation… More >

MIN WANG^1,#, HAILIANG ZHAO^1,2,#, WEIWEI CHEN^3,#, CAIQUN BIE^4,#, JINYING YANG¹, WENRUI CAI¹, CHUTIAN WU¹, YANFANG CHEN¹, SHUFEN FENG¹, YING SHI¹, YUTING LI¹, HUIJUN TANG⁴, LIXIAN ZHONG¹, LILIANGZI GUO¹, SISI CHEN¹, LINJING LONG⁵, SHAOHUI TANG^1,*

Oncology Research, Vol.31, No.4, pp. 515-541, 2023, DOI:10.32604/or.2023.029101

Abstract The dysregulation of exosomal microRNAs (miRNAs) plays a crucial role in the development and progression of cancer. This study investigated the role of a newly identified serum exosomal miRNA miR-4256 in gastric cancer (GC) and the underlying mechanisms. The differentially expressed miRNAs were firstly identified in serum exosomes of GC patients and healthy individuals using next-generation sequencing and bioinformatics. Next, the expression of serum exosomal miR-4256 was analyzed in GC cells and GC tissues, and the role of miR-4256 in GC was investigated by in vitro and in vivo experiments. Then, the effect of miR-4256 on its downstream target genes… More > Graphic Abstract

QIOU GU, TIAN ZHAN, XIAO GUAN, CHUILIN LAI, NA LU, GUOGUANG WANG, LEI XU, XIANG GAO, JIANPING ZHANG^*

Oncology Research, Vol.31, No.3, pp. 287-297, 2023, DOI:10.32604/or.2023.028124

Abstract Background: Gastric cancer (GC) is a malignancy with the worst prognosis that seriously threatens human health, especially in East Asia. Apolipoprotein C1 (apoc1) belongs to the apolipoprotein family. In addition, apoc1 has been associated with various tumors. However, its role in GC remains unclear. Methods: Firstly, we quantified its expression in GC and adjacent tumor tissues, using The Cancer Genome Atlas (TCGA). Next, we assessed cell invasion and migration abilities. Finally, we revealed the role of apoc1 in the tumor microenvironment (TME), immune cell infiltration and drug sensitivity. Results: Firstly, in TCGA database, it has been shown that elevated expression… More >

YI WANG^1,#, SHANGQI CHEN^2,#, PENGCHENG YU¹, ZHEHAN BAO¹, CAN HU¹, YUHANG XIA¹, RUOLAN ZHANG¹, LI YUAN^3,4, HUA RUAN^5,*, JIANCHENG SUN^6,*

BIOCELL, Vol.47, No.5, pp. 991-1002, 2023, DOI:10.32604/biocell.2023.028587

Abstract Aim: Scavenger receptor class B, type I (SR-BI) is an integral plasma membrane protein that has been reported to be overexpressed in various malignancies, such as renal cancer, breast cancer, and prostate cancer, and is an independent prognostic factor. However, the clinical value and expression of SR-BI in GC are unknown. Our research aimed to explore the role of SR-BI in combination with immune markers as a diagnostic and prognostic marker for gastric cancer (GC). Methods: GC tissues, paracancerous tissues, and clinicopathological data of 149 patients were collected. The expression level of SR-BI, Tumor-infiltrating lymphocytes (TILs), and PD-L1 were evaluated… More >

MAN REN^1,2,3,#, YUAN YANG^1,2,#, DAN LI⁴, NANNAN ZHAO⁵, YUPING WANG^2,6,*, YONGNING ZHOU^2,6,*

BIOCELL, Vol.47, No.5, pp. 977-989, 2023, DOI:10.32604/biocell.2023.028402

Abstract Background: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer activity. Methods: In this study, the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular docking. First, the targets of PGG were searched in the Herbal Ingredients’ Targets (HIT), Similarity Ensemble Approach (SEA), and Super-PRED databases. The potential targets related to gastric cancer were predicted from the Human Gene Database (GeneCards) and DisGeNET databases. The intersecting targets of PGG and gastric cancer were obtained by Venn diagram and then subjected to protein-protein interaction analysis to screen hub targets. Functional and… More >

FANBIAO KONG^1,2,#, KUN WU^3,4,#, LIMING PANG^2,#, YULIANG HUANG^2,#, LEI LI³, JING XU², FEITONG LI², YAN QING², ZHONGYU WANG², XIURONG HUANG³, SHENG XU², XIAOGANG ZHONG², ZHOU ZHU², XIAOTONG WANG^3,*, JIANRONG YANG^5,*

Oncology Research, Vol.30, No.6, pp. 277-288, 2022, DOI:10.32604/or.2022.027301

Abstract Introduction: Siva-1, as a pro-apoptotic protein, has been shown to induce extensive apoptosis in a number of different cell lines. In our previous study, we showed that overexpressed Siva-1 decreased the apoptosis of gastric cancer cells. So, we believe that it can also work as an anti-apoptotic protein. The present study aimed to determine the specific role of Siva-1 in anticancer drug resistance in gastric cancer in vivo and in vitro and preliminarily reveal the mechanism. Materials and Methods: A vincristine-resistant MKN-28/VCR gastric cancer cell line with stably downregulated Siva-1 was established. The effect of Siva-1 downregulation on chemotherapeutic drug… More >

Kamalrulnizam Bin Abu Bakar¹, Fatima Tul Zuhra^2,*, Babangida Isyaku^1,3, Fuad A. Ghaleb¹

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 785-798, 2023, DOI:10.32604/cmc.2023.034540

Abstract The Internet of Medical Things (IoMT) emerges with the vision of the Wireless Body Sensor Network (WBSN) to improve the health monitoring systems and has an enormous impact on the healthcare system for recognizing the levels of risk/severity factors (premature diagnosis, treatment, and supervision of chronic disease i.e., cancer) via wearable/electronic health sensor i.e., wireless endoscopic capsule. However, AI-assisted endoscopy plays a very significant role in the detection of gastric cancer. Convolutional Neural Network (CNN) has been widely used to diagnose gastric cancer based on various feature extraction models, consequently, limiting the identification and categorization performance in terms of cancerous… More >

YUANYUAN HUANG^#, HONGMEI WU^#, RUYUAN LIU, SONG JIN, WEILAI XIANG, CHANG YANG, LI XU, XIAONIAN ZHU^*

BIOCELL, Vol.47, No.3, pp. 445-454, 2023, DOI:10.32604/biocell.2023.025880

Abstract The tripartite motif (TRIMs) protein family has E3 ubiquitin ligase activity among most of its members. They participate in multiple cellular processes and signaling pathways in living organisms, including cell cycle, growth, and metabolism, and mediate chromatin modification, transcriptional regulation, post-translational modification, and cellular autophagy. Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients. Here we summarize the biological roles of the TRIMs protein family in cancers. More >

TIANZHU LI^1,#, YU ZHANG^2,#, TONG ZHANG^2,#, YANNAN LI², HUI XUE², JINGLONG CAO², WENSHUANG HOU², YINGHUA LUO^3,*, CHENGHAO JIN^2,4,*,

BIOCELL, Vol.47, No.1, pp. 195-204, 2023, DOI:10.32604/biocell.2023.025593

Abstract Schisandrin B (Sch B) is a monomer with anti-cancer and anti-inflammatory effects, which are isolated from the plant Schisandra chinensis (Turcz) Baillon. We investigated the anti-gastric cancer (GC) effects of Sch B and its underlying molecular mechanisms. The Cell Counting Kit-8 assay was used to determine the effects of Sch B on the viability of GC and normal cell lines. Hoechst/propidium iodide staining and flow cytometry were used to assess the apoptosis induction of Sch B. Western blotting was used to evaluate the effects of Sch B on downstream apoptotic proteins. The DCFH-DA fluorescent probe was used to assess the… More >

BINFEN HOU¹, LI ZHAO¹, T IANHAO ZHAO¹, MINGMING YANG¹, WANWAN ZHU¹, XIAODONG CHEN², XIQUAN KE¹, ZHENZENG MA¹, LIN GU¹, MENG WANG¹, MIN DENG^1,*

BIOCELL, Vol.47, No.1, pp. 175-186, 2023, DOI:10.32604/biocell.2022.021359

Abstract Aim: Gastric cancer (GC) is one of the most common malignant tumors. Chrysophanol has been reported to possess antitumor effects on a variety of cancers; however, its role in GC remains unclear. This study aimed to investigate the effects of chrysophanol on the proliferation, pyroptosis, migration, and invasion of GC cells. Methods: Human GC cell lines MKN 28 and AGS cells were treated with different concentrations of chrysophanol, then cell proliferation, migration, invasion and pyroptosis were determined by CCK-8, colony-forming assay, wound healing assay, Transwell assay, and flow cytometry. Cell migration and invasion were reassessed in these transfected cells following… More >