BIN LIU1,2,#, HAIPENG LIU3,#, FEIFEI REN1,2, HANGFAN LIU1, IHTISHAM BUKHARI1, YUMING FU4, WANQING WU4, MINGHAI ZHAO5, SHAOGONG ZHU6, HUI MO1, FAZHAN LI1,2, MICHAEL B. ZHENG7, YOUCAI TANG1,2, PENGYUAN ZHENG1,2,*, YANG MI1,2,*
Oncology Research, Vol.29, No.2, pp. 87-103, 2021, DOI:10.32604/or.2022.03529
Abstract The activation of some oncogenes promote cancer cell proliferation and growth, facilitate cancer progression
and metastasis by induce DNA replication stress, even genome instability. Activation of the cyclic GMP-AMP synthase
(cGAS) mediates classical DNA sensing, is involved in genome instability, and is linked to various tumor development or
therapy. However, the function of cGAS in gastric cancer remains elusive. In this study, the TCGA database and
retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and
cell lines. By employing cGAS high-expression gastric cancer cell lines, including AGS and MKN45, ectopic silencing
of cGAS caused a significant… More >
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