Rafael Martins de OLIVEIRA, Carolina Bernardi STEFANI, Angélica Aparecida Antoniellis SILVEIRA, Marcelo Lima RIBEIRO, José PEDRAZZOLI Jr., Alessandra GAMBERO*
BIOCELL, Vol.39, No.2-3, pp. 5-8, 2015, DOI:10.32604/biocell.2015.39.005
Abstract Adenosine acts as a gastroprotective factor decreasing inflammation and reducing gastric
acid secretion. Quantitative RT-PCR was used to determine the expression of the adenosine receptor genes
(A1AR, A2AAR, A2BAR and A3AR) and that of the gastrin receptor B gene (CCKBR) in isolated, short-term
cultured enterochromaffin-like (ECL) cells. Both the A1AR and the CCKBR genes were expressed at a level higher than the other genes. Also, the effect of 2-chloroadenosine, a stable agonist of A1 and A2A receptors, was
explored on ECL cells, with a resulting inhibition of both basal and gastrin-stimulated histamine release. Also,
dipropylcyclopentylxanthine (DPCPX), a selective A1 antagonist,… More >
Login
Register
