Hana Chang^*, Melissa L. Knothe Tate^∗,†,‡

Molecular & Cellular Biomechanics, Vol.8, No.4, pp. 297-318, 2011, DOI:10.3970/mcb.2011.008.297

Abstract In the preceding study (Part A), we showed that prescribed seeding conditions as well as seeding density can be used to subject multipotent stem cells (MSCs) to volume changing stresses and that changes in volume of the cell are associated with changes in shape, but not volume, of the cell nucleus. In the current study, we aim to control the mechanical milieu of live cells using these prescribed seeding conditions concomitant to delivery of shape changing stresses via fluid flow, while observing adaptation of the cytoskeleton, a major cellular transducer that modulates cell shape, stiffness… More >

Joshua A. Zimmermann^*, Melissa L. Knothe Tate^∗,†,‡

Molecular & Cellular Biomechanics, Vol.8, No.4, pp. 275-296, 2011, DOI:10.3970/mcb.2011.008.275

Abstract Shape and fate are intrinsic manifestations of form and function at the cell scale. Here we hypothesize that seeding density and protocol affect the form and function of live embryonic murine mesenchymal stem cells (MSCs) and their nuclei. First, the imperative for study of live cells was demonstrated in studies showing changes in cell nucleus shape that were attributable to fixation per se. Hence, we compared live cell and nuclear volume and shape between groups of a model MSC line (C3H10T1/2) seeded at, or proliferated from 5,000 cells/cm2 to one of three target densities to… More >

Ligia Munteanu¹, Veturia Chiroiu¹, Valeria Mosnegutu¹

CMC-Computers, Materials & Continua, Vol.26, No.2, pp. 137-156, 2011, DOI:10.3970/cmc.2011.026.137

Abstract In this paper, yet another method for evaluating the elastic modulus for human bones is introduced and investigated. This method adopts the Jankowski and Tsakalakos strain energy function in which, the Born-Mayer energy term is the predominant term for calculations the elastic constants. By taking accounts the directional aspects of the spatial structure of bones, we obtain different values for the Young's modulus depending on the direction of the applied force with respect to the material's structure. The inverse problem analyzed in this paper is solved by inversion of the experimental data. An efficient stopping More >

De-Shin Liu¹, Zhen-Wei Zhuang¹, Shaw-Ruey Lyu^2,3, Cho-Liang Chung⁴, Pai-Chen Lin¹

CMC-Computers, Materials & Continua, Vol.26, No.2, pp. 111-136, 2011, DOI:10.3970/cmc.2011.026.111

Abstract This study proposes a two-dimensional heterogeneous hybrid moisture element method (HHMEM) for modeling transient moisture diffusion in permeable fiber-reinforced polymer composites.
The HHMEM scheme is based on a heterogeneous hybrid moisture element(HHME), with properties determined through an equivalent hybrid moisture capacitance/conductance matrix. This matrix was calculated using the conventional finite element formulation in space discretization as well as the θ-method in time discretization with similar mass/stiffness properties and matrix condensing operations. A coupled HHME-FE scheme was developed and implemented in computer code MATLAB in order to analyze the transient moisture diffusion characteristics of composite materials containing multiple… More >

Kentaro Doi^1,2, Ikumi Onishi¹, Satoyuki Kawano^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.77, No.2, pp. 113-136, 2011, DOI:10.3970/cmes.2011.077.113

Abstract Hydrogen technologies are currently one of the most actively researched topics. A lot of researches have tied to enhance their energy conversion efficiencies. In the present study, numerical analyses have been carried out focusing on hydrogen-storage carbon materials which are expected to realize high gravimetric and volumetric capacities. In particular, dissociative adsorption processes of H₂ molecules above graphene surfaces have been investigated by ab initio molecular dynamics. The present results indicate that a steric graphene surface plays an important role in enhancing the charge transfer which induces dissociation of H₂ and adsorption of H atoms on the More >

Nizami Gasilov¹, Şahin Emrah Amrahov², Afet Golayoğlu Fatullayev¹, Halil İbrahim Karakaş¹, Ömer Akın³

CMES-Computer Modeling in Engineering & Sciences, Vol.75, No.3&4, pp. 189-204, 2011, DOI:10.3970/cmes.2011.075.189

Abstract In this paper, linear systems with a crisp real coefficient matrix and with a vector of fuzzy triangular numbers on the right-hand side are studied. A new method, which is based on the geometric representations of linear transformations, is proposed to find solutions. The method uses the fact that a vector of fuzzy triangular numbers forms a rectangular prism in n-dimensional space and that the image of a parallelepiped is also a parallelepiped under a linear transformation. The suggested method clarifies why in general case different approaches do not generate solutions as fuzzy numbers. It… More >

Ali Bekir Yildiz¹

CMES-Computer Modeling in Engineering & Sciences, Vol.75, No.1, pp. 33-42, 2011, DOI:10.3970/cmes.2011.075.033

Abstract The generalized method for determination of time constants of linear circuits is introduced. Nodal and mesh analysis, conventional methods whose applications are simpler than the state-space formulation, are used in obtaining the system equations. The approach is based on the use of the relationship between transfer functions and system equations of linear circuits, obtained by the conventional methods. The examples of active and passive circuits are given to illustrate the method. More >

Jorge Daniel Riera¹, Letícia Fleck Fadel Miguel², Ignacio Iturrioz³

CMES-Computer Modeling in Engineering & Sciences, Vol.82, No.2, pp. 113-136, 2011, DOI:10.32604/cmes.2011.082.113

Abstract In the truss-like Discrete Element Method (DEM), masses are considered lumped at nodal points and interconnected by means of uni-dimensional elements with arbitrary constitutive relations. In previous studies of the tensile fracture behavior of concrete cubic samples, it was verified that numerical predictions of fracture of non-homogeneous materials using DEM models are feasible and yield results that are consistent with the experimental evidence so far available. Applications that demand the use of large elements, in which extensive cracking within the elements of the model may be expected, require the consideration of the increase with size… More >

S. Gerace¹, K. Erhart¹, E. Divo^1,2, A. Kassab¹

CMES-Computer Modeling in Engineering & Sciences, Vol.81, No.1, pp. 35-68, 2011, DOI:10.3970/cmes.2011.081.035

Abstract The focus of this work is to demonstrate a novel approach to true CFD automation based on an adaptive Cartesian point distribution process coupled with a Meshless flow solution algorithm. As Meshless method solutions require only an underlying nodal distribution, this approach works well even for complex flow geometries with non-aligned domain boundaries. Through the addition of a so-called shadow layer of body-fitted nodes, application of boundary conditions is simplified considerably, eliminating the stair-casing issues of typical Cartesian-based techniques. This paper describes the approach taken to automatically generate the Meshless nodal distribution, along with the More >

S. Rajagopal¹, Ranjan Ganguli²

CMES-Computer Modeling in Engineering & Sciences, Vol.81, No.1, pp. 1-34, 2011, DOI:10.3970/cmes.2011.081.001

Abstract The preliminary wing design of a low speed, long endurance UAV is formulated as a two step optimization problem. The first step performs a single objective aerodynamic optimization and the second step involves a coupled dual objective aerodynamic and structural optimization. During the first step, airfoil geometry is optimized to get maximum endurance parameter at a 2D level with maximum thickness to chord ratio and maximum camber as design variables. Leading edge curvature, trailing edge radius, zero lift drag coefficient and zero lift moment coefficient are taken as constraints. Once the airfoil geometry is finalized,… More >