A.Wakif^a,* , Z. Boulahia^a, A. Amine^b , I.L. Animasaun^c , M. I. Afridi^d, M. Qasim^d , R. Sehaqui^a

Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-15, 2019, DOI:10.5098/hmt.12.3

Abstract The significance of an externally applied magnetic field and an imposed negative temperature gradient on the onset of natural convection in a thin horizontal layer of alumina-water nanofluid for various sizes of spherical alumina nanoparticles (e.g., 30 More >

Hai-Dong Wanga , Zeng-Yuan Guo^a,*

Frontiers in Heat and Mass Transfer, Vol.13, pp. 1-12, 2019, DOI:10.5098/hmt.13.20

Abstract The classical heat transfer theory is established on the empirical models of Fourier’s heat conduction law and Newton’s cooling law. Although the classical theory has been successfully used in a wide range of industrial engineering applications, it lacks deep understanding of the physical mechanisms for energy transport and analytical methodology based on solid mathematical and mechanical principles. The rapid development of modern science and technology challenges the traditional heat transfer theory in two aspects: (1) Fourier’s law of heat conduction is no longer valid under the ultra-fast laser heating or nanoscale conditions; (2) The optimization… More >

Heng-Pin Hsu^a , Chuo-Jeng Huang^b,*, Herchang Ay^a

Frontiers in Heat and Mass Transfer, Vol.13, pp. 1-8, 2019, DOI:10.5098/hmt.13.14

Abstract The heat and mass transfer characteristics of the influence of uniform blowing/suction and MHD (magnetohydrodynamic) on the free convection of non-Newtonian fluids over a vertical plate in porous media with internal heat generation and Soret/Dufour effects are numerically analyzed. The surface of the vertical plate has a uniform wall temperature and uniform wall concentration (UWT/UWC). The numerical modeling of this problem attracts considerable attention, owing to its practical applications in biological sciences, electronic cooling, advanced nuclear systems, etc. The transformed governing equations are solved by Keller box method. Comparisons showed excellent agreement with the numerical More >

Anne Ruas, Ha Pham, Laura Pinson

Revue Internationale de Géomatique, Vol.29, No.2, pp. 185-205, 2019, DOI:10.3166/rig.2019.00081

Abstract De nombreuses études et recherches visent à mieux connaitre les phénomènes de type pollution ou météo. Les champs de valeur représentant ces phénomènes peuvent être visualisés sur des outils de visualisation scientifiques qui ne disposent pas de la richesse de symbolisation propre aux SIGs, notamment pour le géoréférencement et pour la représentation des objets vectoriels décrivant l’espace support. La représentation sous forme raster sur SIG est possible mais limitée. Pourtant au niveau scientifique il est important de pouvoir co-visualiser les champs dans leur contexte géographique pour mieux les analyser et faire des hypothèses sur les… More >

Yue Kui Jian¹, Huan Ye Zhu¹, Xing Lin Wu, Bo Li

Oncology Research, Vol.27, No.2, pp. 211-218, 2019, DOI:10.3727/096504018X15208993118389

Abstract Osteosarcomas, especially those with metastatic or unresectable disease, have limited treatment options. The antitumor effects of pharmacologic inhibitors of angiogenesis in osteosarcomas are hampered in patients by the rapid development of tumor resistance, notably through increased invasiveness and accelerated metastasis. Here we demonstrated that thrombospondin 1 (TSP-1) is a potent inhibitor of the growth and metastasis of the osteosarcoma cell line MG-63. Moreover, we demonstrate that upregulation of TSP-1 facilitated expression of vasculostatin in MG-63 cells. In angiogenesis assays, overexpression of TSP-1 inhibited MG-63 cells and induced tube formation of human umbilical vein endothelial cells More >

Haizhen Wang^*, Zhenghua Tang^*, Ting Li^*, Menglu Liu^*, Yong Li^†, Baoling Xing^*

Oncology Research, Vol.27, No.9, pp. 1051-1060, 2019, DOI:10.3727/096504019X15561873320465

Abstract Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-rich interactive domain 1A (ARID1A) in progesterone resistance in Ishikawa cells. Ablation of ARID1A was conducted through the CRISPR/Cas9 technology. Acquired progesterone-resistant Ishikawa (Ishikawa-PR) cells were generated by chronic exposure of Ishikawa cells to MPA. The sensitivity of the parental Ishikawa, Ishikawa-PR, and ARID1A-deficient cells to MPA and/or LY294002 was determined using the Cell Counting Kit-8 (CCK-8) assay and flow cytometry analysis.… More >

Linglan Gu, Yi Shi, Weimin Xu, Yangyang Ji

Oncology Research, Vol.27, No.8, pp. 923-933, 2019, DOI:10.3727/096504019X15518706875814

Abstract In previous investigations, we reported that peroxisome proliferator-activated receptor / (PPAR / ) activation by GW501516 inhibits proliferation and promotes apoptosis in the undifferentiated C666-1 nasopharyngeal carcinoma (NPC) cells by modulating caspase-dependent apoptotic pathway. In the present study, the mechanism by which GW501516 induces apoptosis was explored from the perspective of microRNA (miRNA) expression. Among the assayed miRNAs that were involved in regulating the expression of antiapoptotic protein Bcl-2, miR-206 was increased significantly and specifically by GW501516 in C666-1 cells at both the in vitro level and at the in vivo xenograft samples. The induction… More >

Yue Cai^*†‡, Chizhi Zhang^*†‡, Lei Zhan^*†, Liangbin Cheng^*†, Dingbo Lu^*†, Xiaodong Wang^*†, Hanlin Xu^§, Shuxue Wang^¶, Deng Wu^*†, Lianguo Ruan^#

Oncology Research, Vol.27, No.8, pp. 889-899, 2019, DOI:10.3727/096504018X15482423944678

Abstract The thorns of Gleditsia sinensis have been historically used in Chinese medicine and are considered one of the fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and still requires the development of new drugs with higher efficiency. By using a rat HCC model implanted with cancerous Walker-256 cells, the therapeutic effects of G. sinensis extract (GSE) were assessed, as well as its regulatory effects on miRNAs. GSE significantly restored liver morphology and dramatically induced cell apoptosis in HCC rats. In addition, miR-21/181b/183 was More >

Xinwen Wang, Fupeng Zhang, Xi Yang, Meiping Xue, Xiaoli Li, Yu Gao, Likun Liu

Oncology Research, Vol.27, No.8, pp. 871-877, 2019, DOI:10.3727/096504018X15426271404407

Abstract Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), afatinib, has been approved for treating EGFR mutant lung cancer patients, but the mechanism of acquired resistance to afatinib has not been well studied. In this study, we established afatinib acquired resistant cell lines. Gene array technology was used to screen changes in gene expression between afatinib-resistant lung cancer cells and parental cells. Our results showed that secreted phosphoprotein 1 (SPP1) was significantly increased in afatinib-resistant lung cancer cells. To study the effect of SPP1 on afatinib resistance, siSPP1 was used to knock down SSP1 More >

Hongliang Yang^*1, Lei Yan^†1, Kai Sun^‡, Xiaodong Sun^†, Xudong Zhang,§ Kerui Cai^†, Tiejun Song^*

Oncology Research, Vol.27, No.3, pp. 359-369, 2019, DOI:10.3727/096504018X15220594629967

Abstract This study aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-small cell lung cancer (NSCLC) cells. qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and Western blot were employed to measure the expression of the GLI2 downstream proteins. Ki-67 expression in nude mice tumors was tested by immunohistochemistry. MTT assay, wound healing assay, and Transwell assay were used to assess NSCLC cell viability and aggressiveness, respectively. Tumor xenograft was conducted to determine the… More >