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    REVIEW

    Translational aspects of the modern genetics in head and neck cancers

    FRANCESCO PADUANO1,2,*, EMANUELA ALTOMARE2,3, BENEDETTA MARRELLI1, VINCENZO DATTILO4, HAIZAL MOHD HUSSAINI5, PAUL ROY COOPER5, MARCO TATULLO6

    BIOCELL, Vol.46, No.8, pp. 1827-1835, 2022, DOI:10.32604/biocell.2022.020462 - 22 April 2022

    Abstract Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN) category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientific community. GWAS have identified several pathways involved in the interactions among general risk factors and genomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported within the scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis, involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases More >

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