BIN ZHANG1,#, JIANYI ZHAO3,#, YONGZHI WANG2,#, HUA XU1, BO GAO1, GUANGNING ZHANG1, BIN HAN1, GUOHONG SONG1, JUNCHEN ZHANG1,*, WEI MENG1,*
Oncology Research, Vol.31, No.6, pp. 917-927, 2023, DOI:10.32604/or.2023.030425
Abstract Glioblastoma (GBM) is the most aggressive cancer of the brain and has a high mortality rate due to the lack of
effective treatment strategy. Clarification of molecular mechanisms of GBM’s characteristic invasive growth are urgently
needed to improve the poor prognosis. Single-nuclear sequencing of primary and recurrent GBM samples revealed that
levels of M3 muscarinic acetylcholine receptor (CHRM3) were significantly higher in the recurrent samples than in the
primary samples. Moreover, immunohistochemical staining of an array of GBM samples showed that high levels of
CHRM3 correlated with poor prognosis, consistent with The Cancer Genome Atlas database. Knockdown of CHRM3
inhibited… More >
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