Cuirong Xu^1,*, Han Yan², Dawei Xu³, Guanjie Chen⁵, Qian Xu², Kunpeng Li⁶, Yehao Rui⁷, Zanmin Song³, Neeraj Gill³, Jing Sun^3,4,*

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1089-1102, 2023, DOI:10.32604/ijmhp.2023.030526

Abstract Objective: The purpose of this study was to evaluate the effectiveness of post-traumatic growth (PTG) model-based intervention to improve positive psychological traits in Chinese breast cancer patients. Design: A randomized control trial of a psychological group intervention based on PTG model. Methods: The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264. A total of 92 patients with breast cancer were recruited. The participants were randomly assigned to the experimental group (n = 46) and the control group (n = 46). A six-session psychological group intervention based on PTG model was implemented in… More >

M. Zeki KARİPÇİN¹, Behcet İNAL^2,*

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3177-3193, 2023, DOI:10.32604/phyton.2023.030979

Abstract Due to climate change, it is necessary to develop plant varieties that are resilient to climate conditions and resistant to abiotic and biotic stresses. The use of microalgae, which are microorganisms that contain carbohydrates, proteins, lipids, and vitamins, against drought tolerance is a new approach. The aim of the current study was to determine the drought-related mechanisms in the conomon melon genotype and develop drought-tolerant melon cultivars. Morphological, physiological, pomological, and molecular analyses were carried out on the algae-treated genotypes. It has been determined that commercial algae application provides the best results in leaf temperature, leaf relative water contents (LRWC),… More >

Shugufta Parveen¹, Fayaz A. Mohiddin^2,*, M. Ashraf Bhat³, Zahoor Ahmed Baba⁴, Fehim Jeelani⁵, M. Anwar Bhat⁶, Sajad Un Nabi⁷, Burhan Hamid², Saba Bandey⁸, Farhanaz Rasool⁹, Zakir Amin¹, Ibrahim Al-Ashkar^10,*, Muhammad Adnan¹¹, Ayman El Sabagh¹²

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3021-3041, 2023, DOI:10.32604/phyton.2023.030921

Abstract One hundred twenty-five endophytic microorganisms were isolated from the roots, stems, and leaves of four prominent rice cultivars growing in temperate regions. Their potential to combat rice blast disease and promote plant growth was investigated. The dual culture tests highlighted the strong antagonistic activity of five fungal (ranging from 89%–70%) and five bacterial (72%–61%) endophytes. Subsequent examination focused on volatile compounds produced by selected isolates to counter the blast pathogen. Among these, the highest chitinase (13.76 µg mL⁻¹) and siderophore (56.64%), was exhibited by Aspergillus flavus, and the highest HCN production was shown by Stenotrophomonas maltophilia (36.15 µM mL⁻¹). In… More >

MAKOTO KAWATANI^1,2,*, HARUMI AONO², SAYOKO HIRANUMA³, TAKESHI SHIMIZU³, MAKOTO MUROI^1,2, TOSHIHIKO NOGAWA⁴, TOMOKAZU OHISHI⁵, SHUN-ICHI OHBA⁵, MANABU KAWADA⁵, KANAMI YAMAZAKI⁶, SHINGO DAN⁶, NAOSHI DOHMAE¹, HIROYUKI OSADA^2,7,*

Oncology Research, Vol.31, No.6, pp. 833-844, 2023, DOI:10.32604/or.2023.030241

Abstract Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases. This study presents the identification of a potent DHODH inhibitor by proteomic profiling. Cell-based screening revealed that NPD723, which is reduced to H-006 in cells, strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells. H-006 also suppressed the growth of various cancer cells. Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors. H-006 potently inhibited human DHODH activity in vitro, whereas NPD723 was approximately… More >

BIN ZHANG^1,#, JIANYI ZHAO^3,#, YONGZHI WANG^2,#, HUA XU¹, BO GAO¹, GUANGNING ZHANG¹, BIN HAN¹, GUOHONG SONG¹, JUNCHEN ZHANG^1,*, WEI MENG^1,*

Oncology Research, Vol.31, No.6, pp. 917-927, 2023, DOI:10.32604/or.2023.030425

Abstract Glioblastoma (GBM) is the most aggressive cancer of the brain and has a high mortality rate due to the lack of effective treatment strategy. Clarification of molecular mechanisms of GBM’s characteristic invasive growth are urgently needed to improve the poor prognosis. Single-nuclear sequencing of primary and recurrent GBM samples revealed that levels of M3 muscarinic acetylcholine receptor (CHRM3) were significantly higher in the recurrent samples than in the primary samples. Moreover, immunohistochemical staining of an array of GBM samples showed that high levels of CHRM3 correlated with poor prognosis, consistent with The Cancer Genome Atlas database. Knockdown of CHRM3 inhibited… More >

Zhaoli Chen, Ying Liu^*, Bingshan Zeng, Qingbin Jiang, Shengkun Wang, Xiangyang Li

Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2891-2906, 2023, DOI:10.32604/phyton.2023.030664

Abstract Michelia macclurei Dandy is a significant tree species that has extensive cultivation for forestry and horticulture purposes in southern China, owing to its economic and practical importance. Light quality influences plantlet growth and development during tissue culture. However, the growth characteristic and molecular regulation of M. macclurei under different light quality conditions are not well understood yet. In this study, we investigated the morphological, chlorophyll content, and transcriptomic responses of M. macclurei plantlets under different light-emitting diode (LED) qualities, including white, blue, and red light. The results showed that blue light significantly increased plant height (21.29%) and leaf number (18.65%),… More >

Heng Zhang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09243

Abstract Interface fracture is the main failure mode of bonded materials and structures, its theoretical and numerical analysis have caused wide attentions. Peridynamics is a nonlocal meshfree method, which has a great advantage in materials and structures failure analysis. In our recent works [1-3], a general peridynamicsbased framework for elastic bimaterial interface fracture problem analysis was established. The peridynamic interface model with the thermal effect was proposed, the nonlocal form of interface bond force was given. The energy release rate and mode mixity of the interface crack were computed with the peridynamic virtual crack closure technique (PD_VCCT). The extended critical energy… More >

Xingyu Kan^1,*, Yiwei Wang¹, Jiale Yan², Renfang Huang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.2, pp. 1-2, 2023, DOI:10.32604/icces.2023.09937

Abstract Nonlocal differential operators have become an increasingly important tool in the field of numerical modeling and computational science. In recent years, two specific types of nonlocal differential operators have emerged as particularly useful in simulations of material and structural failures, such as fracture and crack propagations in solids. In this paper, the first type of nonlocal operator is based on the nonlocal operator theory in peridynamic theory, which is called PDOs [1,2]. The second type of nonlocal operator is derived from the Taylor series expansion of nonlocal interpolation, which is called NDOs [3-5]. NDOs are usually used to discretize the… More >

Abraham Lamboro^1,3,*, Songnan Yang¹, Xueying Li¹, Dan Yao², Jun Zhang^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.9, pp. 2489-2501, 2023, DOI:10.32604/phyton.2023.029492

Abstract The effect of beta-lactam antibiotics on shoot induction and plantlet regeneration from cotyledonary nodes was tested using two peanut cultivars. The culture media contained 4 mg/L 6-benzylaminopurine (BAP) as the main growth regulator. Various concentrations (100–600 mg/L) of cefotaxime, carbenicillin, and timentin were applied in the culture media. In all the tested media, there were no significant differences in the shoot induction as compared to the control. However, little phytotoxic effect was observed at higher concentrations of these antibiotics in the shoot elongation media. Under shoot elongation medium, shoots turned brownish and partly died at higher concentrations where shooting rates… More >

Ali Bandehagh^1,*, Zahra Dehghanian², Vahideh Gougerdchi¹, Mohammad Anwar Hossain^3,*

Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2301-2324, 2023, DOI:10.32604/phyton.2023.028586

Abstract The presence of selenium (Se) is not widely established as crucial for crops, although it is commonly recognized as an important nutrient for animals as well as humans. Even so, it is inevitably accepted that Se usually contributes positively to the life cycle of plants. Previous findings suggested that small amounts of Se seem to have a productive role in growth and production. As a result, Se is assumed to function in multiple ways, primarily by influencing a variety of biochemical and physiological functions. Also, Se also acts as a plant antioxidant and pro-oxidant and confers tolerance against different abiotic… More >