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  • Open Access

    REVIEW

    How aging affects bone health via the intestinal micro-environment

    HUAN HU1,2,*, YUE HUANG1, FANGZHOU LIU1, QIAN WANG1,2, YANZI YAO3,*

    BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311

    Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on… More >

  • Open Access

    ARTICLE

    Adjuvant effects of Lactobacillus casei added to a renutrition diet in a malnourished mouse model

    PAOLA GAUFFIN CANO1 , GRACIELA AGÜERO3, GABRIELA PERDIGON1,2

    BIOCELL, Vol.26, No.1, pp. 35-48, 2002, DOI:10.32604/biocell.2002.26.035

    Abstract Nutritional deficiencies are associated with impaired immune response, affecting the body’s defence mechanisms. It is also known that Lactic Acid Bacteria (LAB) and fermented products such us yogurt have immunopotentiator activity and nutritional properties, and could thus be used as a valuable supplement in a renutrition diet. The aim of this study was to determine, in a non-severe malnutrition model, the effective dose of Lactobacillus casei (L.casei), which when is used as an adjuvant in a renutrition diet, would modulate the mucosal immune system and induce recovery of the integrity of the intestinal barrier. The experiments were performed on groups… More >

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