YUANYUAN JIA, XIAONA MA, XIURUI YAN, JING XUE, TINGTING YANG, XUEYUN LIANG*, XIAOMING LIU*
BIOCELL, Vol.46, No.2, pp. 479-493, 2022, DOI:10.32604/biocell.2022.015390
Abstract Mesenchymal stem cells (MSCs) capable of tumour topotaxis have been served as cellular vehicles to deliver
anti-tumour agents. As cellular components of the tumour microenvironment, MSCs also affect tumour progression.
However, the tumour transformation-related genes of MSCs remain unclear since either tumorigenic or tumour
suppressor effects within these cells have been researched. Hence, we aimed to identify potential biomarkers indicative
of tumorigenic risk by RNA-seq analysis of human placenta tissue-derived MSCs (hPTMSCs) exposed to the
carcinogenic agent, 3-methylcholanthrene (3-MC). Twenty-nine tumour transformation-related genes and three
pluripotency-related genes were appraised as differentially expressed genes (DEGs) in hPTMSCs. Overexpression of
sfrp1 led… More >
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