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  • Open Access

    ARTICLE

    Data-Driven Prediction and Optimization of Mechanical Properties and Vibration Damping in Cast Iron–Granite-Epoxy Hybrid Composites

    Girish Hariharan1, Vinyas1, Gowrishankar Mandya Chennegowda1, Nitesh Kumar1, Shiva Kumar1, Deepak Doreswamy2, Subraya Krishna Bhat1,*

    CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073772 - 12 January 2026

    Abstract This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite–epoxy (G–E) composites reinforced with cast iron (CI) filler particles. Hybrid G–E composite with added cast iron (CI) filler particles enhances stiffness, strength, and vibration damping, offering enhanced performance for vibration-sensitive engineering applications. Unlike conventional approaches, this work simultaneously employs Artificial Neural Networks (ANN) for high-accuracy property prediction and Response Surface Methodology (RSM) for in-depth analysis of factor interactions and optimization. A total of 24 experimental test data sets of varying input… More >

  • Open Access

    ARTICLE

    Long-Term Bridge Health Evaluation Using Resonant Frequency Changes under Random Loading Conditions

    Thi Kim Chi Duong1, Bich-Ngoc. Mach2, Hoa-Cuc. Nguyen2, Thi Nhu Quynh Trinh2, Thanh Q. Nguyen3,4,*

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.070185 - 08 January 2026

    Abstract This study explores theoretical insights and experimental results on monitoring load-carrying capacity degradation in bridge spans through frequency analysis. Experiments were conducted on real bridge structures, including the Binh Thuan Bridge, focusing on analyzing the power spectral density (PSD) of vibration signals under random traffic loads. Detailed digital models of various bridge spans with different structural designs and construction periods were developed to ensure diversity. The study utilized PSD to analyze the vibration signals from the bridge spans under various loading conditions, identifying the vibration frequencies and the corresponding response regions. The research correlated the… More >

  • Open Access

    ARTICLE

    HE4 Might Participate in Extracellular Matrix Remodeling in Ovarian Cancer via Activation of Fibroblasts

    Yimin Liu1,#, Bin Liu2,3,4,#, Huabin Gao1, Jinlong Wang5, Jingya Duan1, Xiaolan Huang1, Yuexi Liu1, Ying Huang1, Wenjing Liao1, Ruonan Li1,*, Hua Linghu1,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069007 - 30 December 2025

    Abstract Objectives: High-grade serous ovarian cancer (HGSOC), the most common subtype of epithelial ovarian cancer (EOC), exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis. Human epididymis protein 4 (HE4), a key diagnostic biomarker for ovarian cancer, is involved in fibrotic processes in several non-malignant diseases. Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis, this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC. Methods: A total of 126 patients with gynecological conditions were included and divided into… More > Graphic Abstract

    HE4 Might Participate in Extracellular Matrix Remodeling in Ovarian Cancer via Activation of Fibroblasts

  • Open Access

    ARTICLE

    Machine Learning Based Uncertain Free Vibration Analysis of Hybrid Composite Plates

    Bindi Saurabh Thakkar1, Pradeep Kumar Karsh2,*

    CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-22, 2026, DOI:10.32604/cmc.2025.072839 - 09 December 2025

    Abstract This study investigates the uncertain dynamic characterization of hybrid composite plates by employing advanced machine-assisted finite element methodologies. Hybrid composites, widely used in aerospace, automotive, and structural applications, often face variability in material properties, geometric configurations, and manufacturing processes, leading to uncertainty in their dynamic response. To address this, three surrogate-based machine learning approaches like radial basis function (RBF), multivariate adaptive regression splines (MARS), and polynomial neural networks (PNN) are integrated with a finite element framework to efficiently capture the stochastic behavior of these plates. The research focuses on predicting the first three natural frequencies… More >

  • Open Access

    ARTICLE

    Vortex-Induced Vibration Prediction in Floating Structures via Unstructured CFD and Attention-Based Convolutional Modeling

    Yan Li1,2,*, Yibin Wu1,2, Bo Zhang1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2905-2925, 2025, DOI:10.32604/fdmp.2025.072979 - 31 December 2025

    Abstract Traditional Computational Fluid Dynamics (CFD) simulations are computationally expensive when applied to complex fluid–structure interaction problems and often struggle to capture the essential flow features governing vortex-induced vibrations (VIV) of floating structures. To overcome these limitations, this study develops a hybrid framework that integrates high-fidelity CFD modeling with deep learning techniques to enhance the accuracy and efficiency of VIV response prediction. First, an unstructured finite-volume fluid–structure coupling model is established to generate high-resolution flow field data and extract multi-component time-series feature tensors. These tensors serve as inputs to a Squeeze-and-Excitation Convolutional Neural Network (SE-CNN), which… More >

  • Open Access

    CASE REPORT

    Successful treatment of rare vaso-vesical fistula with minimally invasive measures despite prior history of radiotherapy: a case report

    Jordan L. Mendelson1,*, Jordan Kassab1, Phillip Westbrook1, Katie Yang2, Anthony Corcoran1

    Canadian Journal of Urology, Vol.32, No.6, pp. 673-676, 2025, DOI:10.32604/cju.2025.063770 - 30 December 2025

    Abstract Stereotactic body radiotherapy (SBRT) for prostate cancer is a generally well-tolerated treatment but can rarely lead to complications such as fistula formation. We report a 69-year-old male on maintenance ibrutinib for chronic lymphocytic leukemia who developed a fistula between his bladder and vas deferens in the setting of ascending scrotal infection. Despite his prior history of SBRT, the fistula was successfully treated with minimally invasive measures. A combination of abscess debridement, urinary diversion, and broad-spectrum antibiotics helped to achieve fistula resolution. The unique presentation described herein highlights the importance of early aggressive intervention for source More >

  • Open Access

    ARTICLE

    Taraxasterol Ameliorates Pulmonary Fibrosis by Regulating PPP2R1B Expression

    Huiping Qiu1, Shaofang Huang2,*, Xin Xiong1, Li Zhang1

    BIOCELL, Vol.49, No.12, pp. 2415-2432, 2025, DOI:10.32604/biocell.2025.070402 - 24 December 2025

    Abstract Background: Pulmonary fibrosis is an irreversible lung disorder that currently has a limited number of effective therapeutic strategies. Taraxasterol (TAR), a bioactive triterpenoid isolated from plants used in traditional Chinese medicine (TCM), possesses anti-inflammatory and antioxidant activities. However, its precise role in pulmonary fibrosis remains incompletely defined. This study aimed to elucidate whether TAR alleviates pulmonary fibrosis by modulating Protein Phosphatase 2 Scaffold Subunit Abeta (PPP2R1B) expression. Methods: A bleomycin-induced murine model of pulmonary fibrosis and a transforming growth factor-β1 (TGF-β1) stimulated mouse lung fibroblast cell line (MLg) were established. To evaluate the effects of… More >

  • Open Access

    ARTICLE

    Structural and Vibration Characteristics of Rotating Packed Beds System for Carbon Capture Applications Using Finite Element Method

    Yunjun Lee1, Sanggyu Cheon2, Woo Chul Chung1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3381-3403, 2025, DOI:10.32604/cmes.2025.073729 - 23 December 2025

    Abstract The application of carbon capture systems on ships is technically constrained by limited onboard space and the weight of the conventional absorption tower. The rotating packed bed (RPB) has emerged as a promising alternative due to its small footprint and high mass transfer performance. However, despite its advantages, the structural and vibration stability of RPBs at high rotational speed remains insufficiently studied, and no international design standards currently exist for RPBs. To address this gap, this study performed a comprehensive finite element analysis (FEA) using ANSYS to investigate the structural and dynamic characteristics of an… More >

  • Open Access

    ARTICLE

    Random Eigenvibrations of Internally Supported Plates by the Boundary Element Method

    Michał Guminiak1, Marcin Kamiński2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3133-3163, 2025, DOI:10.32604/cmes.2025.071887 - 23 December 2025

    Abstract The analysis of the dynamics of surface girders is of great importance in the design of engineering structures such as steel welded bridge plane girders or concrete plate-column structures. This work is an extension of the classical deterministic problem of free vibrations of thin (Kirchhoff) plates. The main aim of this work is the study of stochastic eigenvibrations of thin (Kirchhoff) elastic plates resting on internal continuous and column supports by the Boundary Element Method (BEM). This work is a continuation of previous research related to the random approach in plate analysis using the BEM.… More >

  • Open Access

    ARTICLE

    Calibrating Trust in Generative Artificial Intelligence: A Human-Centered Testing Framework with Adaptive Explainability

    Sewwandi Tennakoon1, Eric Danso1, Zhenjie Zhao2,*

    Journal on Artificial Intelligence, Vol.7, pp. 517-547, 2025, DOI:10.32604/jai.2025.072628 - 01 December 2025

    Abstract Generative Artificial Intelligence (GenAI) systems have achieved remarkable capabilities across text, code, and image generation; however, their outputs remain prone to errors, hallucinations, and biases. Users often overtrust these outputs due to limited transparency, which can lead to misuse and decision errors. This study addresses the challenge of calibrating trust in GenAI through a human centered testing framework enhanced with adaptive explainability. We introduce a methodology that adjusts explanations dynamically according to user expertise, model output confidence, and contextual risk factors, providing guidance that is informative but not overwhelming. The framework was evaluated using outputs… More >

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