Tim A. Ludwig^1,*, Philip Reiss^1,*, Marco Wieland², Andreas Becker¹, Margit Fisch¹, Felix K. Chun¹, Roland Dahlem¹

Canadian Journal of Urology, Vol.22, No.6, pp. 8100-8104, 2015

Abstract Introduction: The aim was to perform a feasibility study of the new artificial sphincter device ARTUS in human cadavers. ARTUS is a new electro-mechanical device, which may prevent urethral damage due to a new working principle which is to perform only sequential pressure on successive parts of the urethra.
Material and methods: The implantation of the ARTUS device was performed in six cadavers (3 males, 3 females) with different body mass indices. Subsequently the basic operation data (operation time, cuff size, length of wires, complication) were assessed.
Results: The implantation of the ARTUS device is performed easily by… More >

Murtaza Dungerwalla¹, Nicholas Davies², Marlon Perera¹, Nathan Papa¹, Nathan Lawrentschuk^1,3,4

Canadian Journal of Urology, Vol.22, No.6, pp. 8093-8098, 2015

Abstract Introduction: Manual bladder washouts (MBWs) are an integral skill for healthcare workers dealing with urological patients. Despite this they are often overlooked by educators and omitted from formal teaching curricula. We aimed to determine the level of competence and training among healthcare workers in performing a MBW.
Materials and methods: Following a literature review for correct MBW technique, a 15-question survey was developed to assess knowledge and self-reported competency of doctors and nurses in performing a MBW. Two hundred paper and email-based surveys were distributed to doctors and nurses in the urology wards of Australian public and… More >

Victor Srougi, Guilherme P. Padovani, Giovanni S. Marchini, Fabio C. Vicentini, Eduardo Mazzucchi, Miguel Srougi

Canadian Journal of Urology, Vol.22, No.6, pp. 8079-8084, 2015

Abstract Introduction: To evaluate the outcomes of ureteral strictures treatment after endoureterotomy using the holmium laser or open/laparoscopic surgery.
Material and methods: From a database of 1101 patients that underwent semi-rigid holmium laser ureterolithotripsy from 2003 to 2013, we performed a search for patients treated for ureteral stricture. Parameters analyzed included patient demographic, stone burden, and ureteral stricture characteristics. Treatment included holmium laser endoureterotomy for stenosis ≤1 cm and open/laparoscopic repair for stenosis >1 cm or for failed endoscopic treatment. Outcomes and complications were assessed. Success was defined as symptom improvement and radiographic obstruction resolution.
Results: Of all the… More >

Joseph Wagner, Peter Haddock

Canadian Journal of Urology, Vol.22, No.6, pp. 8074-8078, 2015

Abstract Introduction: Bladder neck contractures (BNC) are an uncommon complication following radical prostatectomy. Occasionally, BNCs can be refractory to endoscopic approaches. We describe the effectiveness of a novel robotic-assisted laparoscopic catheterizable bladder augment in treating recalcitrant BNCs.
Materials and methods: Patients undergoing robotic-assisted radical prostatectomy (RALP) between 2004-2014 who developed a postoperative BNC were identified. We documented our experience with robotic-assisted laparoscopic catheterizable bladder augment for recalcitrant BNCs. Total operative time, robotic time, estimated surgical blood, length of hospital stay, serum creatinine, complications, and postoperative course/upper tract imaging were recorded.
Results: Thirty-six of 2002 RALP patients (1.8%) experienced a… More >

Zachary L. Smith¹, Eugene J. Pietzak¹, Chelsey K. Meise², Keith Van Arsdalen¹, Alan J. Wein¹, S. Bruce Malkowicz¹, Thomas J. Guzzo¹

Canadian Journal of Urology, Vol.22, No.6, pp. 8069-8073, 2015

Abstract Introduction: The Fuhrman grading system (FGS) is the most widely utilized pathological classification and predictor of renal cell carcinoma (RCC) prognosis. The aim of this study was to test the prognostic ability of a simplified two-tier FGS.
Materials and methods: We reviewed the data of 509 patients with clear cell RCC who underwent radical or partial nephrectomy between January 1994 and April 2007. The conventional four-tier (I, II, III, IV) FGS was compared to a simplified two-tier FGS in which grades I and II were combined (low grade) and grades III and IV were combined (high grade).… More >

Premal Patel¹, Jasmir G. Nayak^1,2, Zlatica Biljetina⁴, Bryan Donnelly³, Kiril Trpkov⁴

Canadian Journal of Urology, Vol.22, No.6, pp. 8056-8062, 2015

Abstract Introduction: Limited data exist on long term pathological outcomes in patients with initial prostate biopsies showing either high-grade intraepithelial neoplasia (HGPIN) or benign findings, who are subsequently diagnosed with prostate cancer.
Materials and methods: Preoperative characteristics of patients showing either HGPIN or benign initial prostate biopsies were investigated and compared in patients with and without a subsequent diagnosis of prostate cancer. We also compared the biopsy and prostatectomy findings in patients with prostate cancer in both groups.
Results: We evaluated 161 and 85 patients with initial HGPIN and benign prostate biopsies, respectively, who underwent a subsequent biopsy. After… More >

Wunchana Seubwai^*†‡, Kulthida Vaeteewoottacharn^‡§, Ratthaphol Kraiklang^¶, Kazuo Umezawa^#, Seiji Okada^**, Sopit Wongkham^‡§

Oncology Research, Vol.23, No.1-2, pp. 21-28, 2015, DOI:10.3727/096504015X14424348426071

Abstract Cholangiocarcinoma (CCA) is a dismal cancer. At present, there is no effective chemotherapeutic regimen for CCA. This may be due to the marked resistance of CCA to chemotherapy drugs, for which a mechanism remains unknown. Nuclear factor-kB (NF-kB) is constitutively activated in a variety of cancer cells, including CCA. It has been shown to play roles in growth, metastasis, and chemoresistance of cancer. In the present study, we examined whether NF-kB is involved in the chemoresistance of CCA and whether dehydroxymethylepoxyquinomicin (DHMEQ), an effective NF-kB inhibitor, can overcome the drug resistance of CCA. Two CCA… More >

Yun Qin^*, Xicai Tang^†, Mingxing Liu^‡

Oncology Research, Vol.23, No.1-2, pp. 13-20, 2015, DOI:10.3727/096504015X14410238486766

Abstract The purpose of this study was to assess the effects of NBPF1 expression on cervical cancer cell invasion and apoptosis and to illustrate its potential mechanism. Human cervical cancer HeLa cells were transfected with the constructed siNBPF1 or pcDNA3.1-NBPF1 vectors. Effects of NBPF1 expression on cell invasion ability and cell apoptosis were analyzed using the Matrigel method and an Annexin V-FITC cell apoptosis kit, respectively. In addition, cell apoptosis-related proteins involved with the PI3K/mTOR signaling pathway were analyzed using Western blot. Remediation experiments were conducted to verify the effects of NBPF1 expression on cell invasion… More >

Fei Meng, Wei Liu

Oncology Research, Vol.23, No.1-2, pp. 7-12, 2015, DOI:10.3727/096504015X14410238486649

Abstract Cervical cancer is the second leading type of cancer in women living in less developed countries. The pathological and molecular mechanisms of cervical cancer are not comprehensively known. Though legumain has been found to be highly expressed in various types of solid tumors, its expression and biological function in cervical cancer remain unknown. In this study, we aimed to investigate legumain expression and functions in cervical cancer. We found that legumain was highly expressed in cervical cancer cells. When knocked down, legumain expression in HeLa and SiHa cells significantly reduced its migration and invasion abilities More >

Vanita Noronha^*, Kumar Prabhash^*, Amit Joshi^*, Vijay Maruti Patil^*, Sanjay Talole^†, Dipti Nakti^*, Arvind Sahu^*, Srushti Shah^‡, Sarbani Ghosh-Laskar^§, Prachi S. Patil^¶, Shaesta A. Mehta^¶, Nirmala Jambhekar^#, Abhishek Mahajan^**, Nilendu Purandare^††

Oncology Research, Vol.23, No.4, pp. 183-195, 2015, DOI:10.3727/096504016X14537290676865

Abstract There are little data on the efficacy and safety of taxane/platinum with definitive radiotherapy (RT) for esophageal/GEJ cancer. This article is a retrospective analysis of patients who received weekly paclitaxel 50 mg/ m2 and carboplatin AUC 2 with radical definitive RT for locally advanced esophageal/GEJ cancer. Between February 2011 and July 2014, 179 patients were included. The median age was 54 years. Ninety-two percent of patients had squamous histology. Mean RT dose was 58.7 Gy in 32 fractions over 53 days, with mean of six chemotherapy cycles. Fifty-six percent of patients developed ³grade 3 acute… More >