Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

Kai Gui^1,#, Tianyi Yang^1,#, Chengying Xiong¹, Yue Wang¹, Zhiqiang He¹, Wuxian Li^2,3,*, Min Tang^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070143 - 30 December 2025

Abstract Objectives: The mechanism by which specific tumor subsets in colorectal cancer (CRC) use alternative metabolic pathways, particularly those modulated by hypoxia and fructose, to alter the tumor microenvironment (TME) remains unclear. This study aimed to identify these malignant subpopulations and characterize their intercellular signaling networks and spatial organization through an integrative multi-omics approach. Methods: Leveraging bulk datasets, single-cell RNA sequencing, and integrative spatial transcriptomics, we developed a prognostic model based on hypoxia-and fructose metabolism-related genes (HFGs) to delineate tumor cell subpopulations and their intercellular signaling networks. Results: We identified a specific subset of stanniocalcin-2 positive (STC2+)… More > Graphic Abstract

Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Shujie Yin¹, Zong Li¹, Wen-Bin Ou^1,2,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069049 - 30 December 2025

Abstract Ferroptosis is an iron-dependent, excessive lipid peroxidation-driven form of regulated cell death. The core mechanisms of ferroptosis include lipid peroxidation cascade, System X_c⁻-glutathioneglutathione peroxidase 4 axis, iron and lipid metabolism chaos, the NAD(P)Hferroptosis suppressor protein 1—ubiquinone axis, and GTP cyclohydrolase 1 tetrahydrobiopterin-dihydrofolate reductase axis. Cuproptosis is triggered by copper ions and involves ferredoxin 1-mediated aggregation of lipoylated proteins, differing fundamentally from ferroptosis. Both ferroptosis and cuproptosis exhibit dual roles (promote or inhibit) in cancers. And the sensitivity of different cancer types to ferroptosis varies, which may depend on special metabolic signatures (e.g., E-cadherin loss causes epithelial–mesenchymal More > Graphic Abstract

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Mohammed Benamara^1,2, Boumediene Touati³, Said Bennaceur⁴, Bendjillali Ridha Ilyas^5,*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.072641 - 27 December 2025

Abstract This study explores the thin-layer convective solar drying of Marrubium vulgare L. leaves under conditions typical of sun-rich semi-arid climates. Drying experiments were conducted at three inlet-air temperatures (40°C, 50°C, 60°C) and two air velocities (1.5 and 2.5 m·s⁻¹) using an indirect solar dryer with auxiliary temperature control. Moisture-ratio data were fitted with eight widely used thin-layer models and evaluated using correlation coefficient (r), root-mean-square error (RMSE), and Akaike information criterion (AIC). A complementary heat-transfer analysis based on Reynolds and Prandtl numbers with appropriate Nusselt correlations was used to relate flow regime to drying performance, and an… More > Graphic Abstract

Chenxi Xiu^1,2,*, Xihua Chu², Ao Mei¹, Liangfei Gong¹

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-39, 2026, DOI:10.32604/cmc.2025.073193 - 09 December 2025

Abstract Granular materials exhibit complex macroscopic mechanical behaviors closely related to their micro-scale microstructural features. Traditional macroscopic phenomenological elasto-plastic models, however, usually have complex formulations and lack explicit relations to these microstructural features. To avoid these limitations, this study proposes a micromechanics-based softening hyperelastic model for granular materials, integrating softening hyperelasticity with microstructural insights to capture strain softening, critical state, and strain localization behaviors. The model has two key advantages: (1) a clear conceptualization, straightforward formulation, and ease of numerical implementation (via Abaqus UMAT subroutine in this study); (2) explicit incorporation of micro-scale features (e.g., contact… More >

Salahudin Robo^1,2, Triyanna Widiyaningtyas^1,*, Wahyu Sakti Gunawan Irianto¹

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-19, 2026, DOI:10.32604/cmc.2025.073011 - 09 December 2025

Abstract Recommendation systems are an integral and indispensable part of every digital platform, as they can suggest content or items to users based on their respective needs. Collaborative filtering is a technique often used in various studies, which produces recommendations by analyzing similarities between users and items based on their behavior. Although often used, traditional collaborative filtering techniques still face the main challenge of sparsity. Sparsity problems occur when the data in the system is sparse, meaning that only a portion of users provide feedback on some items, resulting in inaccurate recommendations generated by the system.… More >

Alexander V. Savin^1,2, Elena A. Korznikova^3,4, Sergey V. Dmitriev^5,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-20, 2026, DOI:10.32604/cmc.2025.072786 - 09 December 2025

Abstract Due to their chiral structure, carbon nanosprings possess unique properties that are promising for nanotechnology applications. The structural transformations of carbon nanosprings in the form of spiral macromolecules derived from planar coronene and kekulene molecules (graphene helicoids and spiral nanoribbons) are analyzed using molecular dynamics simulations. The interatomic interactions are described by a force field including valence bonds, bond angles, torsional and dihedral angles, as well as van der Waals interactions. While the tension/compression of such nanosprings has been analyzed in the literature, this study investigates other modes of deformation, including bending and twisting. Depending… More >

Ahmed Abdel-Wahab¹, Mohammad Alkhatib^2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-34, 2026, DOI:10.32604/cmc.2025.070010 - 09 December 2025

Abstract Deepfake is a sort of fake media made by advanced AI methods like Generative Adversarial Networks (GANs). Deepfake technology has many useful uses in education and entertainment, but it also raises a lot of ethical, social, and security issues, such as identity theft, the dissemination of false information, and privacy violations. This study seeks to provide a comprehensive analysis of several methods for identifying and circumventing Deepfakes, with a particular focus on image-based Deepfakes. There are three main types of detection methods: classical, machine learning (ML) and deep learning (DL)-based, and hybrid methods. There are… More >