Tong Wu, Dawei Zhou, Qingyu Ou^*, Fang Luo

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073482 - 12 January 2026

Abstract The increasing interconnection of modern industrial control systems (ICSs) with the Internet has enhanced operational efficiency, but also made these systems more vulnerable to cyberattacks. This heightened exposure has driven a growing need for robust ICS security measures. Among the key defences, intrusion detection technology is critical in identifying threats to ICS networks. This paper provides an overview of the distinctive characteristics of ICS network security, highlighting standard attack methods. It then examines various intrusion detection methods, including those based on misuse detection, anomaly detection, machine learning, and specialised requirements. This paper concludes by exploring More >

Rayeesa Mehmood^*, Sergei Koltcov, Anton Surkov, Vera Ignatenko

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072735 - 12 January 2026

Abstract Activation pruning reduces neural network complexity by eliminating low-importance neuron activations, yet identifying the critical pruning threshold—beyond which accuracy rapidly deteriorates—remains computationally expensive and typically requires exhaustive search. We introduce a thermodynamics-inspired framework that treats activation distributions as energy-filtered physical systems and employs the free energy of activations as a principled evaluation metric. Phase-transition–like phenomena in the free-energy profile—such as extrema, inflection points, and curvature changes—yield reliable estimates of the critical pruning threshold, providing a theoretically grounded means of predicting sharp accuracy degradation. To further enhance efficiency, we propose a renormalized free energy technique that More >

Mallikarjun P. Y.¹, Rame Gowda D. N.¹, Trisha J. K.¹, Varshini M.¹, Poornesha S. Shetty¹, Mandar Jatkar^1,*, Arpan Shah²

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072507 - 12 January 2026

Abstract As circuit feature sizes approach the nanoscale, traditional Copper (Cu) interconnects face significant hurdles posed by rising resistance-capacitance (RC) delay, electromigration, and high power dissipation. These limitations impose constraints on the scalability and reliability of future semiconductor technologies. Our paper describes the new Vertical multilayer Aluminium Boron Nitride Nanoribbon (AlBN) interconnect structure, integrated with Density functional theory (DFT) using first-principles calculations. This study explores AlBN-based nanostructures with doping of 1Cu, 2Cu, 1Fe (Iron), and 2Fe for the application of Very Large Scale Integration (VLSI) interconnects. The AlBN structure utilized the advantages of vertical multilayer interconnects… More >

Zhangdi Xie^1,2,*, Cantao Zhuang¹, Yong Wu¹, Linghui Niu¹, Jianming Zhao³

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.070531 - 08 January 2026

Abstract This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing, as well as from a free-field station and roof frame, during a M_w 5.5 magnitude earthquake in Pingyuan, Shandong, in 2023. The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves. The results indicate that during the earthquake, the peak frequency of the free-field and the measurement points… More >

Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

Kai Gui^1,#, Tianyi Yang^1,#, Chengying Xiong¹, Yue Wang¹, Zhiqiang He¹, Wuxian Li^2,3,*, Min Tang^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070143 - 30 December 2025

Abstract Objectives: The mechanism by which specific tumor subsets in colorectal cancer (CRC) use alternative metabolic pathways, particularly those modulated by hypoxia and fructose, to alter the tumor microenvironment (TME) remains unclear. This study aimed to identify these malignant subpopulations and characterize their intercellular signaling networks and spatial organization through an integrative multi-omics approach. Methods: Leveraging bulk datasets, single-cell RNA sequencing, and integrative spatial transcriptomics, we developed a prognostic model based on hypoxia-and fructose metabolism-related genes (HFGs) to delineate tumor cell subpopulations and their intercellular signaling networks. Results: We identified a specific subset of stanniocalcin-2 positive (STC2+)… More > Graphic Abstract

Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Shujie Yin¹, Zong Li¹, Wen-Bin Ou^1,2,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069049 - 30 December 2025

Abstract Ferroptosis is an iron-dependent, excessive lipid peroxidation-driven form of regulated cell death. The core mechanisms of ferroptosis include lipid peroxidation cascade, System X_c⁻-glutathioneglutathione peroxidase 4 axis, iron and lipid metabolism chaos, the NAD(P)Hferroptosis suppressor protein 1—ubiquinone axis, and GTP cyclohydrolase 1 tetrahydrobiopterin-dihydrofolate reductase axis. Cuproptosis is triggered by copper ions and involves ferredoxin 1-mediated aggregation of lipoylated proteins, differing fundamentally from ferroptosis. Both ferroptosis and cuproptosis exhibit dual roles (promote or inhibit) in cancers. And the sensitivity of different cancer types to ferroptosis varies, which may depend on special metabolic signatures (e.g., E-cadherin loss causes epithelial–mesenchymal More > Graphic Abstract

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Mohammed Benamara^1,2, Boumediene Touati³, Said Bennaceur⁴, Bendjillali Ridha Ilyas^5,*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.072641 - 27 December 2025

Abstract This study explores the thin-layer convective solar drying of Marrubium vulgare L. leaves under conditions typical of sun-rich semi-arid climates. Drying experiments were conducted at three inlet-air temperatures (40°C, 50°C, 60°C) and two air velocities (1.5 and 2.5 m·s⁻¹) using an indirect solar dryer with auxiliary temperature control. Moisture-ratio data were fitted with eight widely used thin-layer models and evaluated using correlation coefficient (r), root-mean-square error (RMSE), and Akaike information criterion (AIC). A complementary heat-transfer analysis based on Reynolds and Prandtl numbers with appropriate Nusselt correlations was used to relate flow regime to drying performance, and an… More > Graphic Abstract