Sarah A. Scuderi*, Marika Lanza*, Giovanna Casili*, Francesca Esposito†, Cristina Colarossi‡, Dario Giuffrida‡, Paterniti Irene*, Salvatore Cuzzocrea*,* Emanuela Esposito*, Michela Campolo*
Oncology Research, Vol.28, No.7-8, pp. 779-790, 2020, DOI:10.3727/096504021X16161478258040
Abstract Glioma are common malignant brain tumors, among which glioblastoma multiforme (GBM) has the worst
prognosis. Different studies of GBM revealed that targeting nuclear factor B (NF- B) induced an attenuation
tumor proliferation and prolonged cell survival. TBK1 {TANK [TRAF (TNF (tumor-necrosis-factor) receptorassociated factor)-associated NF- B activator]-binding kinase 1} is a serine/threonine protein kinase, and it is
a member of the I B kinase (IKK) family involved in NF- B pathway activation. The aim of this study was
to investigate the potential effect of BX795, an inhibitor of TBK1, in an in vitro and ex vivo model of GBM.
GBM cell… More >
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