SUBHASH CHANDRA^1,2, SANTWANA PALAI³, EDINARDO FAGNER FERREIRA-MATIAS⁴, IVO CAVALCANTE PITA-NETO⁴, CíCERO LUCAS GOMES-RAMALHO⁴, EDLANE MARTINS DE ANDRADE⁴, RAY SILVA DE ALMEIDA⁵, MARCELLO IRITI^6,7,*, HENRIQUE DOUGLAS MELO-COUTINHO^5,*

BIOCELL, Vol.47, No.4, pp. 677-695, 2023, DOI:10.32604/biocell.2023.026081 - 08 March 2023

Abstract Indian medicinal plants are referred to as the “nectar of life” owing to their phytochemicals and bioactive complexes that are beneficial in treating diseases. Coronavirus disease 2019 (COVID-19) is a global health issue without any proper medication. The indigenous plants of India can be exploited to control the precise signs of SARS-CoV-2. The Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy) has advised routine usage of medicinal plants for COVID-19. Medicinal plants like Zingiber officinalis, Azadirachta indica, Ocimum sanctum, Nigella sativa, Withania somnifera, Curcuma longa, Piper nigrum, Allium sativum, Tinospora cordifolia, etc. have More >

XIANGLAI JIANG^1,2,3,4,#, JIN HE^2,#, YONGFENG WANG^2,3,4,5,#, JIAHUI LIU⁵, XIANGYANG LI⁵, XIANGUI HE⁵, HUI CAI^2,3,4,*

BIOCELL, Vol.47, No.2, pp. 351-366, 2023, DOI:10.32604/biocell.2023.025157 - 18 November 2022

Abstract B and T-lymphocyte attenuator (BTLA) plays an immunosuppressive role by inhibiting T- and B-cell functions. BTLA is associated with a variety of diseases, especially cancer immunity. However, the function of BTLA in various cancers and its clinical prognostic value have still not been comprehensively analyzed. This study aimed to identify the relationship between BTLA and cancer from the perspectives of differences in BTLA expression, its clinical value, immune infiltration, and the correlation with immune-related genes in various cancers. Data regarding mRNA expression, miRNA expression, lncRNA expression, and clinical data of patients of 33 existing cancers… More >

LIPING GONG¹, MING JIA^2,*

BIOCELL, Vol.47, No.1, pp. 109-123, 2023, DOI:10.32604/biocell.2023.024620 - 26 September 2022

Abstract ATP binding cassette subfamily C member 8 (ABCC8) encodes a protein regulating the ATP-sensitive potassium channel. Whether the level of ABCC8 mRNA in lower grade glioma (LGG) correlates with immune cell infiltration and patient outcomes has not been evaluated until now. Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets. The association between ABCC8 and tumor immune cell infiltration, diverse gene mutation characteristics, tumor mutation burden (TMB), and survival in LGG was also investigated in several independent datasets. Pathway enrichment analysis was conducted to search for ABCC8-associated… More >

Xuelian Du^1,#, Hao Shi^2,#, Haiyan Liu¹, Linghua Zhou¹, Anqun Xie¹, Jufang Guo^1,*

Oncologie, Vol.24, No.4, pp. 769-787, 2022, DOI:10.32604/oncologie.2022.026248 - 31 December 2022

Abstract Background: Gestational diabetes mellitus (GDM) affects the health of numerous women around the world. A recent study has shown that GDM is associated with an increased incidence of cancer. In this study, we aimed to explore the possible shared mechanisms and potential common therapeutic targets between GDM and cancer. Methods: The limma package was used to identify differentially expressed genes (DEGs) in GDM. The Cytoscape plugin cytoHubba was used to screen hub genes. The CIBERSORT algorithm was used to explore the correlation between hub genes and immunity. Cox regression analysis was used to assess the relationship… More >

FEIFEI TIAN¹, HUAN HU¹, DI WANG¹, HUAN DING¹, QINGJIA CHI², HUAPING LIANG³, WENLI ZENG^4,*

BIOCELL, Vol.46, No.10, pp. 2291-2301, 2022, DOI:10.32604/biocell.2022.020198 - 13 June 2022

Abstract This study used transcriptome and epigenetic data to predict the prognosis of immune-related genes (IRGs) Apelin (APLN) in patients with hepatocellular carcinoma (HCC). The TCGA database has gene expression and clinical data for HCC. And DNA methylation 450 k data for HCC was download from the University of California Santa Cruz (UCSC) Xena browser. Performing clinical and prognostic analysis of APLN expression, results show that APLN is highly expressed in tumor samples. And it has an increasing trend with the development of clinical stage and T stage. To explore the prognostic role of APLN, the… More >

Hirdayesh Anuragi¹, Rajesh Kumar Singhal², Yashfa Tanveer³, Humaira Yasmin³, Ambati Srijan⁴, Alka Bharati¹, Lal Chand⁵, Sukumar Taria¹, Kunasekaran Rajarajan¹, Asha Ram¹, Arun Kumar Handa¹, Ayyanadar Arunachalam¹, Khalid Rehman Hakeem^6,7,8,*, Deniz Özbilici⁹, Ayman EL Sabagh^10,11,*

Phyton-International Journal of Experimental Botany, Vol.91, No.9, pp. 1831-1858, 2022, DOI:10.32604/phyton.2022.020540 - 13 May 2022

Abstract A severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led novel coronavirus disease (COVID-19) outbreak spread through China has become the biggest global public health challenge today. The virus upon several mutations has led to the resurgence of more infectious and lethal variants infecting over 298 million people with more than 5.46 million deaths worldwide by the end of December, 2021. Though vaccines are available, various preventive measures particularly a high body immunity is still extremely important which determines the likelihood of disease severity and subsequent recovery in the current and future pandemics. This review acknowledges the… More >

Hajer Faris¹, Musaria Karim Mahmood², Osama Ahmad Alomari^3,*, Ashraf Elnagar⁴

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5643-5661, 2022, DOI:10.32604/cmc.2022.026228 - 21 April 2022

Abstract Wireless sensor networks (WSNs) are characterized by their ability to monitor physical or chemical phenomena in a static or dynamic location by collecting data, and transmit it in a collaborative manner to one or more processing centers wirelessly using a routing protocol. Energy dissipation is one of the most challenging issues due to the limited power supply at the sensor node. All routing protocols are large consumers of energy, as they represent the main source of energy cost through data exchange operation. Cluster-based hierarchical routing algorithms are known for their good performance in energy conservation… More >

Yousef Ibrahim Daradkeh¹, Volodymyr Gorokhovatskyi², Iryna Tvoroshenko^2,*, Mujahed Al-Dhaifallah³

CMC-Computers, Materials & Continua, Vol.72, No.1, pp. 1785-1797, 2022, DOI:10.32604/cmc.2022.025499 - 24 February 2022

Abstract The results of the development of the new fast-speed method of classification images using a structural approach are presented. The method is based on the system of hierarchical features, based on the bitwise data distribution for the set of descriptors of image description. The article also proposes the use of the spatial data processing apparatus, which simplifies and accelerates the classification process. Experiments have shown that the time of calculation of the relevance for two descriptions according to their distributions is about 1000 times less than for the traditional voting procedure, for which the sets More >

Xiaolei Li^*

Energy Engineering, Vol.119, No.2, pp. 665-680, 2022, DOI:10.32604/ee.2022.019292 - 24 January 2022

Abstract Aiming at the difficulty of rolling bearing fault diagnosis of wind turbine under noise environment, a new bearing fault identification method based on the Improved Anti-noise Residual Shrinkage Network (IADRSN) is proposed. Firstly, the vibration signals of wind turbine rolling bearings were preprocessed to obtain data samples divided into training and test sets. Then, a bearing fault diagnosis model based on the improved anti-noise residual shrinkage network was established. To improve the ability of fault feature extraction of the model, the convolution layer in the deep residual shrinkage network was replaced with a Dense-Net layer. More >

SERGIU PASCA^1,*, ANCUTA JURJ²

BIOCELL, Vol.46, No.3, pp. 579-581, 2022, DOI:10.32604/biocell.2022.017926 - 18 November 2021

Abstract Ten eleven translocation (TET) enzymes are composed of three representatives: TET1/2/3 which are involved in the hydroxymethylation of methylated cytosines. Because of the wide array of processes that are governed by these epigenetic marks, there have been a wide range of clinical effects associated with TET alterations. Even though many research groups have focused on analyzing the effect of TET alterations within certain cells, few have taken into consideration the effect of TET in the context of intercellular communication. One important entity through which intercellular communication occurs is represented by exosomes. Thus, in the current More >