Chiara Dalle Fratte*, Silvia Mezzalira*, Jerry Polesel†, Elena De Mattia*, Antonio Palumbo‡, Angela Buonadonna§, Elisa Palazzari¶, Antonino De Paoli¶, Claudio Belluco#, Vincenzo Canzonieri‡** , Giuseppe Toffoli*, Erika Cecchin*
Oncology Research, Vol.28, No.9, pp. 847-855, 2020, DOI:10.3727/096504021X16232280278813
Abstract Pathological complete response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
is related to a favorable prognosis. The identification of early biomarkers predictive of pathological complete
response would help optimize the multimodality management of the patients. A panel of 11 tumor-related
proteins was investigated by immunohistochemistry in the pretreatment biopsy of a group of locally advanced
rectal cancer patients to identify early biomarkers of pathological complete response to neoadjuvant chemoradiotherapy. A mono-institutional retrospective cohort of 95 stage II/III locally advanced rectal cancer patients
treated with neoadjuvant chemoradiotherapy and surgery was selected based on clinical–pathological characteristics and the availability of… More >
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