Fang Xu^1,2,#, Wan Li^1,#, Xiang-Jin Zheng^1,2, Yue Hao^1,2, Yi-Hui Yang^1,2, Hong Yang^1,2, Sen Zhang^1,2, Wan-Xin Cao^1,2, Xiao-Xue Li^1,2, Xu Zhang^1,2, Guan-Hua Du^1,2, Teng-Fei Ji^1,*, Jin-Hua Wang^1,2,*

Oncology Research, Vol.33, No.8, pp. 1969-1989, 2025, DOI:10.32604/or.2025.062386 - 18 July 2025

Abstract Objectives: Colorectal cancer (CRC) is one of the most common cancers all over the world. The progression of CRC is associated with inflammation and disruptions in intestinal flora. 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) has been noted for its potent anti-inflammatory properties. However, the effect of AKBA on colon cancer caused by inflammation and its mechanism are not unclear. The study is to explore the effect of AKBA on CRC and its mechanism. Materials and Methods: Cell proliferation, (5-ethynyl-2^′-deoxyuridine, EdU)-DNA synthesis assay and colony formation were used to assess the effect of AKBA on the proliferation of CRC cells.… More >

JI ZENG^1,2,3,#, XUETENG MENG^1,3,#, YUAN ZHANG^1,3, JUN LI¹, TAOTAO MA^1,3,4, CHENG HUANG^1,3,*

Oncology Research, Vol.33, No.7, pp. 1739-1755, 2025, DOI:10.32604/or.2025.061978 - 26 June 2025

Abstract Background: Renal cell carcinoma (RCC) is a prevalent malignancy characterized by a rising incidence and significant mortality. Interleukins (ILs) are crucial in regulating immune cell trafficking and exhibit anti-tumor properties. However, limited research has explored the expression levels and prognostic significance of interleukins in RCC. Methods: In this comprehensive study, we performed a detailed analysis of interleukins in RCC patients using multiple bioinformatics tools, including Oncomine, UALCAN, GEPIA, Kaplan-Meier plotter, cBioPortal, GeneMANIA, TRRUST, STRING, and Linked Omics. Results: Our analysis demonstrated a significant upregulation in the transcriptional levels of IL4, IL7, IL15, IL16, IL23A, IL26, and… More >

Federico Licastro^*

BIOCELL, Vol.49, No.6, pp. 981-989, 2025, DOI:10.32604/biocell.2025.062303 - 24 June 2025

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease causing the most frequent form of dementia in old age. AD etiology is still uncertain and deposition of abnormal proteins in the brain along with chronic neuroinflammation have been suggested as pathogenic mechanisms of neuronal death. Infections by exogenous neurotropic virus, endogenous retrovirus reactivation, infections by other microbes, and air pollutants may either induce neurodegeneration or activate brain inflammation. Up to 8% of the human genome has a retroviral origin. These ancient retroviruses, also called human endogenous retroviruses, are associated with a clinical history of several neurodegenerative diseases.… More >

MIAO YAN¹, DONGXUAN CHI², WEN WANG³, PEI PEI⁴, MIN XIE¹, SHUANGLING LI^1,*

BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025

Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >

ARTEM P. GUREEV¹, IRINA S. SADOVNIKOVA¹, EKATERINA V. CHERNYSHOVA¹, EKATERINA P. KRUTSKIKH¹, IRINA B. PEVZNER², LJUBAVA D. ZOROVA², VERONIKA V. NESTEROVA¹, POLINA I. BABENKOVA¹, EGOR Y. PLOTNIKOV^2,*

BIOCELL, Vol.49, No.5, pp. 873-892, 2025, DOI:10.32604/biocell.2025.063557 - 27 May 2025

Abstract Background: Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease (AD). Resveratrol is a promising compound for the treatment of various neurodegenerative diseases, including AD. Aims: To investigate mitochondrial damage and the effects of resveratrol on inflammation, cognitive function, and mitochondrial quality control in APP/PS1 mice. Methods: Comparative analysis of mitochondrial DNA (mtDNA) damage was conducted between 10-month-old APP/PS1 mice and age-matched C57BL/6 mice. Assessments included measurement of amyloid-β levels, inflammatory markers, swimming distance in the Morris water maze, and gut microbiome composition. Resveratrol’s effects on cytokine expression, mtDNA levels in plasma, and… More >

Darya Ivashkevich, Arina Ponomarenko^*, Igor Manzhulo, Inessa Dyuizen

BIOCELL, Vol.49, No.4, pp. 607-627, 2025, DOI:10.32604/biocell.2025.061606 - 30 April 2025

Abstract The high prevalence of obesity and associated nonalcoholic fatty liver disease (NAFLD) in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these pathologies. The search for new endogenous bioregulators of lipid metabolism and their inclusion in therapeutic regimens for the treatment of patients is becoming a potentially promising direction in science and medicine. Oleoylethanolamide (OEA) is an endogenous lipid mediator capable of exerting multiple hypolipidemic, anti-inflammatory, and hepatoprotective effects mediated by agonism with receptors of the peroxisome proliferator-activated receptor (PPAR) family (PPAR-α and PPAR-γ). This review focuses on More >

Kuo-Yang Huang¹, Sheng-Chien Lin^2,3, Chun-Hung Su^4,5,6, Sheng-Wen Wu^4,7, Ching-Chi Tseng^8,9, Wei-Chin Hung¹⁰, Shih-Pin Chen^4,5, Yu-Hsiang Kuan^2,3,*

BIOCELL, Vol.49, No.2, pp. 315-334, 2025, DOI:10.32604/biocell.2025.061073 - 28 February 2025

Abstract ABSTRACT: Background: Acute respiratory distress syndrome (ARDS) is the major therapeutic dilemma associated with significant inflammation and severe pulmonary dysfunction. Liriodendrin is a bioactive compound extract from traditional Chinese medicine, historically utilized for modulating inflammatory responses and alleviating symptoms in multiple disease models. Methods: At present, BALB/c mice were used to explore the effects of liriodendrin on lipopolysaccharide (LPS)-induced ARDS. Before LPS was administered, the mice were treated with either liriodendrin or dexamethasone. Leukocyte infiltration, lung edema, and alveolar-capillary barrier integrity were evaluated in the bronchoalveolar lavage fluid (BALF) and pulmonary parenchyma. The expression of adhesion… More >

ELMIRA YAKUPOVA¹, VALENTINA BABENKO^1,2, ALEXEY BOCHARNIKOV¹, KSENIYA FEDULOVA¹, DENIS SILACHEV^1,2, EGOR PLOTNIKOV^1,2,*

BIOCELL, Vol.48, No.12, pp. 1827-1834, 2024, DOI:10.32604/biocell.2024.058496 - 30 December 2024

Abstract Background: The active use of stem and progenitor cells in the therapy of various diseases requires the development of approaches for targeted modification of their properties. One such approach is the induction of a pro- or anti-inflammatory phenotype. Methods: In this study, we investigated the effect of a pro-inflammatory environment in vitro on multipotent mesenchymal stromal cells (MSC) by incubation with lipopolysaccharide (LPS). iCELLigence real-time cell analysis system was used for monitoring cell culture growth. Cell energy metabolism was assessed using the Seahorse XFp Analyzer. For the rat stroke experiment, we used a photoinduced thrombosis (PT)… More >

Luxin Liang¹, Bing Wang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.012682

Abstract Background: Even though the modulatory effects of Mg and its alloys on bone healing cells during the last two decades, relatively limited attention has been paid on their inflammation-modulatory properties. Understanding the activation process of macrophages in response to the dynamic degradation process of Mg as well as the relationship between macrophage phenotypes and their osteogenic potential is critical for the design and development of advanced Mg-based or Mg-incorporated biomaterials.
Methods: In this work, Ti-0.625Mg (wt.%) alloy fabricated by mechanical alloying (MA) and subsequent spark plasma sintering (SPS) was employed as a material model to explore the inflammatory response… More >

TINGTING LIU^#, DINGYOU GUO^#, JIANSHE WEI^*

BIOCELL, Vol.48, No.8, pp. 1155-1179, 2024, DOI:10.32604/biocell.2024.051518 - 02 August 2024

Abstract In China, Parkinson’s disease (PD) is the second most prevalent central nervous system (CNS) degenerative illness affecting middle-aged and older persons. Movement disorders including resting tremor, bradykinesia, myotonia, postural instability, and gait instability are the predominant clinical symptoms. The two main types of PD are sporadic and familial, with sporadic PD being the more prevalent of the two. The environment, genetics, mitochondrial dysfunction, oxidative stress, inflammation, protein aggregation and misfolding, loss of trophic factors, cell death, and gut microbiota may all have a role in the etiology of PD. PD is inversely connected with other More >