Kuo-Yang Huang1, Sheng-Chien Lin2,3, Chun-Hung Su4,5,6, Sheng-Wen Wu4,7, Ching-Chi Tseng8,9, Wei-Chin Hung10, Shih-Pin Chen4,5, Yu-Hsiang Kuan2,3,*
BIOCELL, Vol.49, No.2, pp. 315-334, 2025, DOI:10.32604/biocell.2025.061073
- 28 February 2025
Abstract ABSTRACT: Background: Acute respiratory distress syndrome (ARDS) is the major therapeutic dilemma associated
with significant inflammation and severe pulmonary dysfunction. Liriodendrin is a bioactive compound extract from
traditional Chinese medicine, historically utilized for modulating inflammatory responses and alleviating symptoms
in multiple disease models. Methods: At present, BALB/c mice were used to explore the effects of liriodendrin on
lipopolysaccharide (LPS)-induced ARDS. Before LPS was administered, the mice were treated with either liriodendrin
or dexamethasone. Leukocyte infiltration, lung edema, and alveolar-capillary barrier integrity were evaluated in
the bronchoalveolar lavage fluid (BALF) and pulmonary parenchyma. The expression of adhesion… More >