É. Budyn1, A. Bilagi2, V. Subramanian3, A.A. Espinoza Orías4, N. Inoue4
CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.3, pp. 341-374, 2014, DOI:10.32604/cmes.2014.098.341
Abstract Focal damage such as cartilaginous defects, erosions, micro-fractures, Schmorl nodes and thinning in the human vertebral endplate are thought to contribute to intervertebral disc degeneration by compromising the nutrition transport between the vertebral bone marrow and the disc nucleus pulposus. However, microfractures in the endplate are currently not detectable by conventional clinical radiographic methods. Nonetheless high quality visualisation of the human endplate is possible by means of advanced light microscopy and appropriate staining. The objective of this study focuses on efficient and inexpensive multi-scale protocols to prepare the surfaces of human endplate specimens for morphometric characterisations at the tissue and… More >
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