Kai Luo^#, Jinghao Zheng^#, Yanjun Pan, Zhongqun Zhu, Xiaomin He^*, Hao Zhang^*

Structural and Congenital Heart Disease, Vol.21, No.2, 2026, DOI:10.32604/schd.2026.078290 - 11 June 2026

Abstract Background Double outlet right ventricle (DORV) is a complex congenital heart disease with significant anatomical variations. Patients with atrioventricular discordance have traditionally been managed with univentricular palliation strategies. However, advances in surgical concepts and techniques have enabled biventricular or one-and-a-half ventricle repair in selected patients, even after prior palliation. Case presentation We report a case of a 32-year-old woman with DORV and atrioventricular discordance who successfully underwent conversion to a one-and-a-half ventricle circulation using a combined Hemi-Mustard/Rastelli procedure with preservation of a pre-existing bidirectional Glenn shunt, performed 18 years after initial palliation. Conclusion This case More >

Shotaro Nozaki, Hiroyuki Oikawa, Naofumi F. Sumitomo^*, Kentaro Tomita, Satoshi Narumi

Structural and Congenital Heart Disease, Vol.21, No.2, 2026, DOI:10.32604/schd.2026.076771 - 11 June 2026

Abstract Background: Many anesthetics suppress atrioventricular conduction and may exacerbate atrioventricular block (AVB), which has led to the establishment of pediatric perioperative guidelines. However, the perioperative management of patients with a history of AVB who have recovered to an apparent sinus rhythm remains unclear. Case presentation: We report the case of a 13-year-old girl who developed complete AVB following surgery for congenital heart disease in infancy and subsequently recovered sinus rhythm. She experienced a recurrence of AVB after anesthesia induction for scoliosis surgery. An implantable pacemaker was inserted in infancy after the onset of complete AVB.… More >

Ghada Atteia¹, Abdulaziz Altamimi², Nihal Abuzinadah³, Khaled Alnowaiser⁴, Muhammad Umer^5,*, Yunyoung Nam⁶, Yongwon Cho^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.1, 2026, DOI:10.32604/cmes.2026.078510 - 27 April 2026

Abstract Cardiovascular diseases (CVD) remain the leading cause of global mortality, making early and accurate diagnosis essential for improving patient outcomes. However, most existing deep learning approaches address cardiac image segmentation or disease classification independently, limiting their effectiveness in complex clinical decision-making scenarios. In this study, we propose an explainable spatio-temporal deep learning framework that integrates segmentation-guided representation learning with efficient temporal modeling for automated CVD detection. The proposed architecture incorporates the Segment Anything Model for Medical Imaging in 2D (SAM-Med2D) to achieve accurate cardiac structure segmentation, followed by Mamba-based temporal feature extraction and Transformer-driven spatial… More >

Michael I. Bukrinsky¹, Alessio L. Ravani², Anastasia V. Poznyak^3,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.072752 - 21 April 2026

Abstract Atherosclerosis (AS) is a key contributor to ischemic heart disease, resulting in significant cardiovascular (CV) morbidity and mortality worldwide. Despite advancements in managing conventional risk factors, including the utilization of statins, recurrent adverse cardiovascular events remain prevalent, emphasizing the need for novel therapeutic strategies. This review explores the critical role of inflammation in the pathogenesis of coronary artery disease (CAD) and highlights potential atheroprotective approaches targeting inflammatory pathways. We discuss the multifaceted interplay between immune responses and AS, detailing the contributions of myeloid cells, T lymphocytes, and various cytokines in plaque formation and instability. Recent More >

Jiafei He^1,2, Ailixiati Alifu², Haifan Wang², Renwei Chen^1,2,*

Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.075858 - 31 March 2026

Abstract Hyperglycemia in pregnancy (HIP) is an important independent risk factor for congenital heart disease (CHD) in offspring. With an increasing number of women of childbearing age experiencing gestational hyperglycemia, the impact of an intrauterine hyperglycemic environment on fetal development has drawn significant attention. However, the teratogenic mechanisms underlying its effects on cardiac development remain incompletely understood. This review systematically analyzes relevant literature to summarize its underlying mechanisms and key findings: A hyperglycemic environment disrupts cardiac neural crest cell migration, differentiation, and the proliferation/apoptosis balance of cardiomyocytes by inducing oxidative stress, endoplasmic reticulum stress, and inflammatory… More >

Alessio L. Ravani¹, Michael I. Bukrinsky², Anastasia V. Poznyak^3,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.074266 - 23 March 2026

Abstract Atherosclerosis (AS) remains a major contributor to cardiovascular disease (CVD) mortality worldwide. Its development involves dysregulated lipid handling, persistent vascular inflammation, and endothelial cell (EC) dysfunction, influenced by genetic, environmental, and lifestyle factors. Increasing evidence highlights a pivotal role of endoplasmic reticulum (ER) stress as a molecular link between lipid dysregulation and inflammatory signaling in AS pathogenesis. ER stress is triggered by modified LDL, oxidized lipids, hyperhomocysteinemia, oxidative stress (OS), and disrupted calcium (Ca²⁺) homeostasis, leading to activation of the unfolded protein response (UPR). Core UPR mediators—inositol-requiring enzyme 1 (IRE1), protein kinase RNA-like ER kinase (PERK),… More >

Zhen Wu^1,2, Hao Liu³, Linlin Zhang⁴, Zehui Zhang^5,*, Jie Wu¹, Haibin He¹, Bin Zhou⁶

CMC-Computers, Materials & Continua, Vol.87, No.1, 2026, DOI:10.32604/cmc.2025.075156 - 10 February 2026

Abstract Recently, Internet of Things (IoT) has been increasingly integrated into the automotive sector, enabling the development of diverse applications such as the Internet of Vehicles (IoV) and intelligent connected vehicles. Leveraging IoV technologies, operational data from core vehicle components can be collected and analyzed to construct fault diagnosis models, thereby enhancing vehicle safety. However, automakers often struggle to acquire sufficient fault data to support effective model training. To address this challenge, a robust and efficient federated learning method (REFL) is constructed for machinery fault diagnosis in collaborative IoV, which can organize multiple companies to collaboratively More >

Rasit Dinc¹, Nurittin Ardic^2,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072337 - 23 January 2026

Abstract Neutrophil extracellular traps (NETs) have emerged as key mediators of cardiovascular diseases (CVDs), linking innate immune activation to vascular injury, thrombosis, and maladaptive remodeling. This review synthesizes recent insights into the molecular and cellular pathways driving NET formation, including post-translational modifications, metabolic reprogramming, inflammasome signaling, and autophagy. It highlights the role of NETs in atherosclerosis, thrombosis, myocardial ischemia-reperfusion injury, and hypertension, emphasizing common control points such as peptidylarginine deiminase 4 (PAD4)-dependent histone citrullination and nicotinamide adenine dinucleotide phosphate oxidases 2 (NOX2)-mediated oxidative stress. Mechanistic interpretation of circulating biomarkers, including myeloperoxidase (MPO)-DNA complexes, citrullinated histone H3,… More >

Hui Wei^1,2, Zhanfei Ma^1,3,*, Jing Jiang¹, Bisheng Wang¹, Zhong Di¹

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-25, 2026, DOI:10.32604/cmc.2025.069236 - 10 November 2025

Abstract The Internet of Vehicles (IoV) operates in highly dynamic and open network environments and faces serious challenges in secure and real-time authentication and consensus mechanisms. Existing methods often suffer from complex certificate management, inefficient consensus protocols, and poor resilience in high-frequency communication, resulting in high latency, poor scalability, and unstable network performance. To address these issues, this paper proposes a secure and efficient distributed authentication scheme for IoV with reputation-driven consensus and SM9. First, this paper proposes a decentralized authentication architecture that utilizes the certificate-free feature of SM9, enabling lightweight authentication and key negotiation, thereby… More >

Jae Hong Lee¹, Seung Min Baek², Hye Won Kwon³, Sungkyu Cho^3,4, Jae Gun Kwak^3,4, Woong-Han Kim^3,4,5,*

Congenital Heart Disease, Vol.20, No.6, pp. 647-658, 2025, DOI:10.32604/chd.2025.075046 - 10 February 2026

Abstract Background: We evaluated surgical outcomes of biventricular repair for atrioventricular septal defect (AVSD) with tetralogy of Fallot (TOF) or double-outlet right ventricle (DORV). Methods: This retrospective pilot study included 12 patients who underwent biventricular repair of AVSD with TOF (n = 6) or DORV (n = 6) between 2004 and 2023. Right ventricular outflow tract (RVOT) reconstruction was performed using transannular patch (TAP, n = 4) or pulmonary valve preservation (PVP, n = 8). Clinical outcomes, including longitudinal pulmonary valve growth, RVOT obstruction, and pulmonary regurgitation, were reviewed descriptively, with particular focus on the feasibility of PVP.… More >