Andres H. Guillen Lozoya, Milad Bonakdarhashemi, Sevann Helo, Matthew Ziegelmann, Tobias Kohler^*

Canadian Journal of Urology, Vol.33, No.4, pp. 923-930, 2026, DOI:10.32604/cju.2026.075775 - 21 August 2026

Abstract Erectile dysfunction (ED) has evolved from a quality-of-life concern to a recognized marker of systemic vascular disease and an early harbinger of cardiovascular events. The Princeton IV Consensus underscores that men presenting with erectile dysfunction should be presumed at increased cardiovascular risk until proven otherwise, advocating integrated risk stratification and lifestyle optimization. Beyond established risk scores, advances in omics, vascular imaging, and digital health promise precision tools for early detection and prevention. This review aims to examine erectile dysfunction as an early marker of cardiovascular disease and to summarize current and emerging approaches to cardiovascular More >

Whitnee Hogan^1,2,*, Thomas S. Przybycien^3,4, Anita J. Moon-Grady^3,4

Structural and Congenital Heart Disease, Vol.21, No.3, 2026, DOI:10.32604/schd.2026.085038 - 31 July 2026

Abstract Improvements in fetal cardiac imaging have highlighted the need for large, multidisciplinary collaborations to further advance fetal cardiovascular care. The Fetal Cardiac Intervention Registry (IFCIR), established in 2011, aims to improve outcomes in fetuses with congenital heart disease (CHD) considered amenable to fetal cardiac intervention (FCI). The registry compiles data from multiple international centers to better define indications, selection criteria, procedural techniques, complications, and outcomes of FCI. The Fetal Heart Society (FHS), founded in 2014, is a non-profit organization dedicated to advancing the understanding of in utero cardiovascular physiology through collaborative research, education and mentorship. The… More >

Israt Jahan¹, Afsana Begum¹, Bibhas Roy Chowdhury Piyas^1,*, Fahmid Al Farid^2,3,*, Fatama Jannat Tisha¹, Shahrin Islam¹, Abu Saleh Musa Miah⁴, Hezerul Abdul Karim^3,*

CMC-Computers, Materials & Continua, Vol.88, No.3, 2026, DOI:10.32604/cmc.2026.081631 - 23 July 2026

Abstract Transforming underlying cardiovascular risk into actionable clinical decisions remains a major challenge in contemporary healthcare. Despite advances in cardiology, early-stage cardiovascular disease often remains undetected, which hinders timely intervention and leads to preventable deaths. To overcome this problem, this study presents an explainable machine learning framework for the early diagnosis of cardiovascular disease (CVD). Initially, this study examined several data-balancing strategies, for example, SMOTE (Synthetic Minority Over-sampling Technique), SMOTETomek (Synthetic Minority Over-sampling Technique + Tomek Links), Tomek Links, ADASYN (Adaptive Synthetic Sampling), and SMOTE-ENN (Synthetic Minority Over-sampling Technique-Edited Nearest Neighbors) within the data-preprocessing pipeline. We… More >

Karim Gasmi^1,*, Afrah Alanazi², Inam Alanazi², Sahar Almenwer¹, Norah Alanazi¹, Sarah Almaghrabi³, Samia Yahyaoui⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.3, 2026, DOI:10.32604/cmes.2026.081705 - 30 June 2026

Abstract Cardiac magnetic resonance imaging (MRI) segmentation is an essential aspect of quantitative cardiovascular analysis, facilitating accurate evaluation of ventricular volumes, myocardial mass, and functional parameters. Deep learning-based segmentation models have shown strong performance on benchmark datasets such as ACDC, but they remain challenging to deploy in real-world multi-centre settings. Data privacy laws make it hard to share data across institutions, and differences in imaging protocols and patient populations mean that data is not always distributed in the same way (non-IID). This can have a big impact on how well models work together and how well… More >

Beata Franczyk¹, Anna Bajer^1,#, Anna Bulicz^1,#, Mikołaj Grabarczyk^1,#, Paulina Jakubowska^1,#, Katarzyna Krawiranda^1,#, Natalia Kustosik^1,#, Przemysław Kuzar^1,#, Klaudia Leszto^1,#, Maja Mejza^1,#, Weronika Mstowska^1,#, Jacek Rysz², Ewelina Młynarska^1,*

BIOCELL, Vol.50, No.7, 2026, DOI:10.32604/biocell.2026.075767 - 29 June 2026

Abstract Cellular senescence and the Senescence-Associated Secretory Phenotype (SASP) play both physiological and pathological roles in the cardiovascular system. While transient senescence aids regeneration, chronic accumulation of senescent cells promotes endothelial dysfunction, arterial stiffening, and maladaptive cardiac remodeling. This review elucidates the pivotal role of the immune system in senescent cell clearance and explores how immunosenescence drives systemic low-grade inflammation. Significant emphasis is placed on emerging pharmacological strategies, specifically senolytics and senomorphics, assessing their capacity to restore cardiac function and attenuate atherosclerosis. Additionally, the utility of molecular biomarkers and diverse in vitro and in vivo models is analyzed More >

Kai Luo^#, Jinghao Zheng^#, Yanjun Pan, Zhongqun Zhu, Xiaomin He^*, Hao Zhang^*

Structural and Congenital Heart Disease, Vol.21, No.2, 2026, DOI:10.32604/schd.2026.078290 - 11 June 2026

Abstract Background Double outlet right ventricle (DORV) is a complex congenital heart disease with significant anatomical variations. Patients with atrioventricular discordance have traditionally been managed with univentricular palliation strategies. However, advances in surgical concepts and techniques have enabled biventricular or one-and-a-half ventricle repair in selected patients, even after prior palliation. Case presentation We report a case of a 32-year-old woman with DORV and atrioventricular discordance who successfully underwent conversion to a one-and-a-half ventricle circulation using a combined Hemi-Mustard/Rastelli procedure with preservation of a pre-existing bidirectional Glenn shunt, performed 18 years after initial palliation. Conclusion This case More >

Shotaro Nozaki, Hiroyuki Oikawa, Naofumi F. Sumitomo^*, Kentaro Tomita, Satoshi Narumi

Structural and Congenital Heart Disease, Vol.21, No.2, 2026, DOI:10.32604/schd.2026.076771 - 11 June 2026

Abstract Background: Many anesthetics suppress atrioventricular conduction and may exacerbate atrioventricular block (AVB), which has led to the establishment of pediatric perioperative guidelines. However, the perioperative management of patients with a history of AVB who have recovered to an apparent sinus rhythm remains unclear. Case presentation: We report the case of a 13-year-old girl who developed complete AVB following surgery for congenital heart disease in infancy and subsequently recovered sinus rhythm. She experienced a recurrence of AVB after anesthesia induction for scoliosis surgery. An implantable pacemaker was inserted in infancy after the onset of complete AVB.… More >

Ghada Atteia¹, Abdulaziz Altamimi², Nihal Abuzinadah³, Khaled Alnowaiser⁴, Muhammad Umer^5,*, Yunyoung Nam⁶, Yongwon Cho^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.1, 2026, DOI:10.32604/cmes.2026.078510 - 27 April 2026

Abstract Cardiovascular diseases (CVD) remain the leading cause of global mortality, making early and accurate diagnosis essential for improving patient outcomes. However, most existing deep learning approaches address cardiac image segmentation or disease classification independently, limiting their effectiveness in complex clinical decision-making scenarios. In this study, we propose an explainable spatio-temporal deep learning framework that integrates segmentation-guided representation learning with efficient temporal modeling for automated CVD detection. The proposed architecture incorporates the Segment Anything Model for Medical Imaging in 2D (SAM-Med2D) to achieve accurate cardiac structure segmentation, followed by Mamba-based temporal feature extraction and Transformer-driven spatial… More >

Michael I. Bukrinsky¹, Alessio L. Ravani², Anastasia V. Poznyak^3,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.072752 - 21 April 2026

Abstract Atherosclerosis (AS) is a key contributor to ischemic heart disease, resulting in significant cardiovascular (CV) morbidity and mortality worldwide. Despite advancements in managing conventional risk factors, including the utilization of statins, recurrent adverse cardiovascular events remain prevalent, emphasizing the need for novel therapeutic strategies. This review explores the critical role of inflammation in the pathogenesis of coronary artery disease (CAD) and highlights potential atheroprotective approaches targeting inflammatory pathways. We discuss the multifaceted interplay between immune responses and AS, detailing the contributions of myeloid cells, T lymphocytes, and various cytokines in plaque formation and instability. Recent More >

Jiafei He^1,2, Ailixiati Alifu², Haifan Wang², Renwei Chen^1,2,*

Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.075858 - 31 March 2026

Abstract Hyperglycemia in pregnancy (HIP) is an important independent risk factor for congenital heart disease (CHD) in offspring. With an increasing number of women of childbearing age experiencing gestational hyperglycemia, the impact of an intrauterine hyperglycemic environment on fetal development has drawn significant attention. However, the teratogenic mechanisms underlying its effects on cardiac development remain incompletely understood. This review systematically analyzes relevant literature to summarize its underlying mechanisms and key findings: A hyperglycemic environment disrupts cardiac neural crest cell migration, differentiation, and the proliferation/apoptosis balance of cardiomyocytes by inducing oxidative stress, endoplasmic reticulum stress, and inflammatory… More >