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  • Open Access

    ARTICLE

    Knowledge-based reconstruction for measurement of right ventricular volumes on cardiovascular magnetic resonance images in a mixed population

    Elise D. Pieterman1,2, Ricardo P. J. Budde2, Danielle Robbers-Visser1,2, Ron T. van Domburg3, Willem A. Helbing1,2

    Congenital Heart Disease, Vol.12, No.5, pp. 561-569, 2017, DOI:10.1111/chd.12484

    Abstract Objective: Follow-up of right ventricular performance is important for patients with congenital heart disease. Cardiac magnetic resonance imaging is optimal for this purpose. However, observerdependency of manual analysis of right ventricular volumes limit its use. Knowledge-based reconstruction is a new semiautomatic analysis tool that uses a database including knowledge of right ventricular shape in various congenital heart diseases. We evaluated whether knowledge-based reconstruction is a good alternative for conventional analysis.
    Design: To assess the inter- and intra-observer variability and agreement of knowledge-based versus conventional analysis of magnetic resonance right ventricular volumes, analysis was done by two observers… More >

  • Open Access

    ARTICLE

    Preparing adolescents with heart problems for transition to adult care, 2009–2010 National Survey of Children with Special Health Care Needs

    Karrie F. Downing1,2, Matthew E. Oster1,3, Sherry L. Farr1

    Congenital Heart Disease, Vol.12, No.4, pp. 497-506, 2017, DOI:10.1111/chd.12476

    Abstract Objective: A substantial percentage of children with congenital heart disease (CHD) fail to transfer to adult care, resulting in increased risk of morbidity and mortality. Transition planning discussions with a provider may increase rates of transfer, yet little is known about frequency and content of these discussions. We assessed prevalence and predictors of transition-related discussions between providers and parents of children with special healthcare needs (CSHCN) and heart problems, including CHD.
    Design: Using parent-reported data on 12- to 17-year-olds from the 2009–2010 National Survey of CSHCN, we calculated adjusted prevalence ratios (aPR) for associations between demographic factors… More >

  • Open Access

    ARTICLE

    Impaired atrioventricular transport in patients with transposition of the great arteries palliated by atrial switch and preserved systolic right ventricular function: A magnetic resonance imaging study

    Magalie Ladouceur1,2,3, Nadjia Kachenoura4, Gilles Soulat1,3, Emilie Bollache4, Alban Redheuil4, Michel Azizi3, Christophe Delclaux3, Gilles Chatellier3, Pierre Boutouyrie1,3, Laurence Iserin3, Damien Bonnet2,3, Elie Mousseaux1,3

    Congenital Heart Disease, Vol.12, No.4, pp. 458-466, 2017, DOI:10.1111/chd.12472

    Abstract Objectives: We aimed (1) determine if systemic right ventricle filling parameters influence systemic right ventricle stroke volume in adult patients with D-transposition of the great arteries (D-TGA) palliated by atrial switch, using cardiac magnetic resonance imaging and echocardiography, and (2) to study relationship of these diastolic parameters with exercise performance and BNP, in patients with preserved systolic systemic right ventricle function.
    Design: Single-center, cross-sectional, prospective study.
    Setting: In patients with D-TGA palliated by atrial switch, diastolic dysfunction of the systemic right ventricle may precede systolic dysfunction.
    Methods: Forty-five patients with D-TGA and atrial switch and 45 age and sex-matched… More >

  • Open Access

    ARTICLE

    Use of 3D models of congenital heart disease as an education tool for cardiac nurses

    Giovanni Biglino1,2, Claudio Capelli2,3, Despina Koniordou3, Di Robertshaw2, Lindsay-Kay Leaver2, Silvia Schievano2,3, Andrew M. Taylor2,3, Jo Wray2

    Congenital Heart Disease, Vol.12, No.1, pp. 113-118, 2017

    Abstract Background: Nurse education and training are key to providing congenital heart disease (CHD) patients with consistent high standards of care as well as enabling career progression. One approach for improving educational experience is the use of 3D patient-specific models.
    Objectives: To gather pilot data to assess the feasibility of using 3D models of CHD during a training course for cardiac nurses; to evaluate the potential of 3D models in this context, from the nurses’ perspective; and to identify possible improvements to optimise their use for teaching.
    Design: A cross-sectional survey.
    Setting: A national training week for cardiac nurses.
    Participants: One… More >

  • Open Access

    ARTICLE

    Comparative Evaluation of Flow Quantification across the Atrioventricular Valve in Patients with Functional Univentricular Heart after Fontan’s Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization

    Hoi Lam She*, Arno A.W. Roest, Emmeline E. Calkoen, Pieter J. van den Boogaard, Rob J. van der Geest, Mark G. Hazekamp§, Albert de Roos, Jos J.M. Westenberg

    Congenital Heart Disease, Vol.12, No.1, pp. 40-48, 2017

    Abstract Purpose. To evaluate the inflow pattern and flow quantification in patients with functional univentricular heart after Fontan’s operation using 4D flow magnetic resonance imaging (MRI) with streamline visualization when compared with the conventional 2D flow approach.
    Method. Seven patients with functional univentricular heart after Fontan’s operation and twenty-three healthy controls underwent 4D flow MRI. In two orthogonal two-chamber planes, streamline visualization was applied, and inflow angles with peak inflow velocity (PIV) were measured. Transatrioventricular flow quantification was assessed using conventional 2D multiplanar reformation (MPR) and 4D MPR tracking the annulus and perpendicular to the streamline inflow at… More >

  • Open Access

    ARTICLE

    IVUS-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment

    Molecular & Cellular Biomechanics, Vol.9, No.1, pp. 77-94, 2012, DOI:10.3970/mcb.2012.009.077

    Abstract Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high More >

  • Open Access

    ABSTRACT

    Intravascular Ultrasound (IVUS)-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment

    Mingchao Cai, Chun Yang, Mehmet H. Kural, Richard Bach, David Muccigrosso, Deshan Yang, Jie Zheng, Kristen L. Billiar, Dalin Tang

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.19, No.4, pp. 97-104, 2011, DOI:10.3970/icces.2011.019.097

    Abstract Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better risk assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. We propose a procedure where intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling are combined together to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. More >

  • Open Access

    ARTICLE

    A General Constitutive Model for Vascular Tissue Considering Stress Driven Growth and Biological Availability

    F. J. Bellomo1, S. Oller2, F. Armero3, L. G. Nallim1

    CMES-Computer Modeling in Engineering & Sciences, Vol.80, No.1, pp. 1-22, 2011, DOI:10.3970/cmes.2011.080.001

    Abstract Some of the key factors that regulate growth and remodeling of tissues are fundamentally mechanical. However, it is important to take into account the role of biological availability to generate new tissue together with the stresses and strains in the processes of natural or pathological growth. In this sense, the model presented in this work is oriented to describe growth of vascular tissue under "stress driven growth" considering biological availability of the organism. The general theoretical framework is given by a kinematic formulation in large strain combined with the thermodynamic basis of open systems. The… More >

  • Open Access

    ARTICLE

    Cyclic Bending Contributes to High Stress in a Human Coronary Atherosclerotic Plaque and Rupture Risk: In Vitro Experimental Modeling and Ex Vivo MRI-Based Computational Modeling Approach

    Chun Yang∗,†, Dalin Tang∗,‡, Shunichi Kobayashi§, Jie Zheng, Pamela K. Woodard§, Zhongzhao Teng*, Richard Bach||, David N. Ku∗∗

    Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 259-274, 2008, DOI:10.3970/mcb.2008.005.259

    Abstract Many acute cardiovascular syndromes such as heart attack and stroke are caused by atherosclerotic plaque ruptures which often happen without warning. MRI-based models with fluid-structure interactions (FSI) have been introduced to perform flow and stress/strain analysis for atherosclerotic plaques and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment. In this paper, cyclic bending was added to 3D FSI coronary plaque models for more accurate mechanical predictions. Curvature variation was prescribed using the data of a human left anterior descending (LAD) coronary artery. Five computational models were constructed based on ex vivo MRI… More >

  • Open Access

    ABSTRACT

    Image-Based Computational Modeling for Cardiovascular Diseases with Potential Clinical Applications

    Dalin Tang1, Chun Yang2, Pedro N. del Nido3, Tal Geva3, Chun Yuan4, Tom Hatsukami5, Fei Liu4, Jie Zheng6, Pamela K. Woodard6

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.1, No.1, pp. 1-6, 2007, DOI:10.3970/icces.2007.001.001

    Abstract Image-based computational models for blood flow in the heart and diseased arteries have been developed for disease assessment and potential clinical applications. Models with fluid-structure interactions for human right ventricle (RV) remodeling surgery design, carotid and coronary atherosclerotic plaques and abdominal aortic aneurysm (AAA) were presented. Organ morphology, material properties, governing equations, proper initial and boundary conditions, controlling factors and research focuses for each model were discussed. More >

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