Hong YE1,6,#, WeiWei Wang2,#, Yu Ding3,#, XiaoLei Liu4,#, WenJI Jia1, WeiLi Luo1, HuiJuan Fan1, HongQun Zhou1, Jin Wang1, JianLong Ju1, DongMing Zhou7, TianHao Bao5,1,*, YuHong Zhu1,*
BIOCELL, Vol.42, No.3, pp. 79-86, 2018, DOI:10.32604/biocell.2018.04615
Abstract Ischemic postconditioning (IP) has been shown to provide protection for ischemia/reperfusion (IR)
injury, but its efficacy is limited. In this study we hypothesized that spontaneous running wheel (RW) could improve
neuroprotection efficacy of IP for IR. We established mouse models of IR and showed that compared to Sham group,
IR group had obvious brain infract and neurological dysfunction. In IR+IP group, brain infract and neurological
dysfunction improved compared to IR group. However, in IR+IP+RW group brain infract and neurological dysfunction
improved much better. TUNEL assay showed that IP but not RW significantly reduced the number of apoptotic cells
after IR.… More >
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