MUNEEBA MALIK1, MAMOONA MAQBOOL2, TOOBA NISAR3, TAZEEM AKHTER4, JAVED AHMED UJAN5,6, ALANOOD S. ALGARNI7, FAKHRIA A. AL JOUFI8, SULTAN SHAFI K. ALANAZI9, MOHAMMAD HADI ALMOTARED10, MOUNIR M. SALEM BEKHIT11, MUHAMMAD JAMIL12,*
Oncology Research, Vol.31, No.6, pp. 899-916, 2023, DOI:10.32604/or.2023.030760
Abstract The low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin
resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer
greater insight into drug resistance. To this end, a series of in silico and in vitro experiments were conducted to
identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes
involved in cisplatin resistance across KIRC were retrieved from the National Center for Biotechnology Information
(NCBI) database using search terms as “Kidney renal clear cell carcinoma” and “Cisplatin resistance”. The genes
retrieved were analyzed… More >
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