SANDRA STICKLER, BARBARA RATH, GERHARD HAMILTON^*

Oncology Research, Vol.32, No.5, pp. 799-805, 2024, DOI:10.32604/or.2024.045356

Abstract Pancreatic cancer has a dismal prognosis due to late detection and lack of efficient therapies. The Kirsten rat sarcoma virus (KRAS) oncogene is mutated in up to 90% of all pancreatic ductal adenocarcinomas (PDACs) and constitutes an attractive target for therapy. However, the most common KRAS mutations in PDAC are G12D (44%), G12V (34%) and G12R (20%) that are not amenable to treatment by KRAS G12C-directed cysteine-reactive KRAS inhibitors such as Sotorasib and Adagrasib that exhibit clinical efficacy in lung cancer. KRAS G12C mutant pancreatic cancer has been treated with Sotorasib but this mutation is detected only in 2%–3% of… More >

Nawab Hussain^1,*, Saud M. Alsulami¹, Hind Alamri^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.3, pp. 2617-2648, 2023, DOI:10.32604/cmes.2023.023143

Abstract In this paper, we present the existence and uniqueness of fixed points and common fixed points for Reich and Chatterjea pairs of self-maps in complete metric spaces. Furthermore, we study fixed point theorems for Reich and Chatterjea nonexpansive mappings in a Banach space using the Krasnoselskii-Ishikawa iteration method associated with and consider some applications of our results to prove the existence of solutions for nonlinear integral and nonlinear fractional differential equations. We also establish certain interesting examples to illustrate the usability of our results. More >

Amir Imran Faisal Hamdi, Johnson Stanslas^*

Oncologie, Vol.24, No.2, pp. 185-194, 2022, DOI:10.32604/oncologie.2022.023629

Abstract KRAS mutations are among the most common oncogenic abnormalities in cancer. Until recently, drug discovery pursuing KRAS did not produce therapeutic benefits for patients. Specific KRAS inhibitors, such as sotorasib and adagrasib, which bind covalently to codon 12 of substituted glycine to cysteine residue of the protein (G12C), have been approved by the FDA recently for the treatment of lung cancers. Binding of these drugs to the protein inhibits the activation of the GDP-bound inactive state to the GTP-bound active state. Phase 1/2 trials have shown potential anti-tumor activity, particularly in patients with previously treated non-small cell lung cancer. Acquired… More >

Guobao Zhang^a,b, Jing-Jing Xiong^a,b, Yongming Huang^a,b, Yong Lu^a,b,c, Ling Wang^a,b

Intelligent Automation & Soft Computing, Vol.24, No.3, pp. 541-551, 2018, DOI:10.31209/2018.100000021

Abstract This paper investigates the delay-dependent stability problem of recurrent neural networks with time-varying delay. A new and less conservative stability criterion is derived through constructing a new augmented Lyapunov-Krasovskii functional (LKF) and employing the linear matrix inequality method. A new augmented LKF that considers more information of the slope of neuron activation functions is developed for further reducing the conservatism of stability results. To deal with the derivative of the LKF, several commonly used techniques, including the integral inequality, reciprocally convex combination, and free-weighting matrix method, are applied. Moreover, it is found that the obtained stability criterion has a lower… More >

D. Vijeswaran^1,*, V. Manikandan²

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 801-813, 2019, DOI:10.32604/cmes.2019.07793

Abstract In a cyber-physical micro-grid system, wherein the control functions are executed through open communication channel, stability is an important issue owing to the factors related to the time-delay encountered in the data transfer. Transfer of feedback variable as discrete data packets in communication network invariably introduces inevitable time-delays in closed loop control systems. This delay, depending upon the network traffic condition, inherits a time-varying characteristic; nevertheless, it adversely impacts the system performance and stability. The load perturbations in a micro-grid system are considerably influenced by the presence of fluctuating power generators like wind and solar power. Since these non-conventional energy… More >

V. Venkatachalam^{1, *}, D. Prabhakaran¹

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.3, pp. 321-334, 2018, DOI:10.3970/cmes.2018.114.321

Abstract This paper presents, using Lyapunov-Krasovskii functional technique combined with reciprocal convex lemma is considered for a networked control temperature control system with additive time-varying-delays. In the stability analysis, a new LK functional is assumed, and take the time-derivative of the (LK) functional, using reciprocal convex combination technique was employed to obtain less conservative stability criteria. Finally, the proposed stability analysis culminates into a stability criterion in the LMI (linear matrix inequalities) framework. The results obtained are in accordance with the theoretically obtained in the temperature control system and they are closer to the standard benchmark temperature-control system. More >