YAN ZHENG1,2, SIHUI MA3,4,*, KATSUHIKO SUZUKI4, HISANORI KATO3, HUIJUAN JIA3,*
BIOCELL, Vol.47, No.8, pp. 1897-1906, 2023, DOI:10.32604/biocell.2023.027632
Abstract Mental disorders such as depression and anxiety inflict significant burdens on individuals and society. Commonly prescribed treatments often involve cognitive therapy and medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD and its key metabolite, β-hydroxybutyrate (BHB), have been hypothesized to alleviate mental disorders through anti-inflammatory actions, a crucial pathway in the pathophysiology of depression. This mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental disorders. Both human and animal studies were scrutinized to elucidate possible… More >
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