FANGHAO SUN1, WENCHAO ZHAO1, LIANSHENG ZHANG2, HONGGUI MA1, JIAN ZHOU1, YOUGAN CHEN1, JIANQUAN HOU1,*
BIOCELL, Vol.44, No.4, pp. 639-647, 2020, DOI:10.32604/biocell.2020.013053
Abstract Recent studies suggested that LIM and SH3 protein 1 (LASP-1) is a promising therapeutic target for renal cell
cancer (RCC). This study aimed to explore the role of LASP-1 in RCC. For this purpose, LASP-1 expression in RCC
tissues was analyzed by immunohistochemistry and Western blot analysis. Cell proliferation, migration, invasion, and
gene expression were detected by CCK-8 assay, Transwell assay, and Western blot analysis. The results showed that
LASP-1 was highly expressed in RCC, and its expression level,t was positively correlated with lymph node metastasis
and tumor, nodes, and metastases (TNM) stage. The knockdown of LASP-1 expression significantly inhibited… More >
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