Takashi Saito^*†, Atsuo Okamura^‡, Junichiro Inoue^†, Daisuke Makiura^†, Hisayo Doi^§, Kimikazu Yakushijin^¶, Hiroshi Matsuoka^¶, Yoshitada Sakai^†#, Rei Ono^*

Oncology Research, Vol.27, No.4, pp. 469-474, 2019, DOI:10.3727/096504018X15267574931782

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed a retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Forty patients (indolent lymphoma, n=9; diffuse large B-cell lymphoma; n=31) received R-CHOP therapy from September 2009 to July 2014. The median age of patients was 58 years (range=27–76 years). Statistical analyses were applied to… More >

Qiuyun Luo^*†1, Wentao Pan^*†‡1, Suna Zhou^*†1, Guangfeng Wang^‡, Hanjie Yi^*§, Lin Zhang^*¶, Xianglei Yan^*†, Luping Yuan^*†, Zhenyi Liu^#, Jing Wang^**, Haibo Chen^#, MiaoZhen Qiu^*††, DaJun Yang^*†‡, Jian Sun^*‡‡

Oncology Research, Vol.28, No.4, pp. 331-344, 2020, DOI:10.3727/096504020X15825405463920

Abstract Despite therapeutic advances, the effective treatment for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) remains a major clinical challenge. Evasion of apoptosis through upregulating antiapoptotic B-cell lymphoma-2 (BCL-2) family members and p53 inactivation, and abnormal activation of B-cell receptor signaling pathway are two important pathogenic factors for DLBCL. In this study, our aim is to explore a rational combination of BCL-2 inhibitor plus Bruton’s tyrosine kinase (BTK) blockade or p53 activation for treating DLBCL with the above characteristics. We demonstrated that a novel BCL-2 selective inhibitor APG-2575 effectively suppressed DLBCL with BCL-2 high expression via activating the mitochondrial apoptosis… More >

D. Loganathan^1,*, M. Balasubramani¹, R. Sabitha², S. Karthik²

Computer Systems Science and Engineering, Vol.44, No.1, pp. 99-112, 2023, DOI:10.32604/csse.2023.023120

Abstract Sensors are considered as important elements of electronic devices. In many applications and service, Wireless Sensor Networks (WSNs) are involved in significant data sharing that are delivered to the sink node in energy efficient manner using multi-hop communications. But, the major challenge in WSN is the nodes are having limited battery resources, it is important to monitor the consumption rate of energy is very much needed. However, reducing energy consumption can increase the network lifetime in effective manner. For that, clustering methods are widely used for optimizing the rate of energy consumption among the sensor nodes. In that concern, this… More >

Indra Mamad Gandidi^1,2,*, Edy Suryadi³, Efri Mardawati³, Dwi Rustam Kendarto³, Nugroho Agung Pambudi^4,*

Energy Engineering, Vol.119, No.3, pp. 1169-1178, 2022, DOI:10.32604/ee.2022.018821

Abstract Pyrolysis is one of the thermal cracking methods to convert hydrocarbon to liquid fuel. The quantity and quality of the process are dependent on several condition including temperature, reaction time, catalyst, and the type of reactor. Meanwhile, a gasoline fraction was maximum product to be considered in the pyrolisis process. Therefore, this study aims to increase the gasoline fraction in liquid fuel using stepwise pyrolysis with a long bed catalytic reactor downstream (LBCR). The LBCR downstream was equipped with the top and bottom outlet and the fed source was mixed municipal solid waste (MMSW). The activated natural dolomite at 500°C… More >

JIYU WANG^#, YING PAN^#, YANG WAN, ZHIXIANG WANYAN, ZHITAO WANG, QIANSHAN TAO, ZHIMIN ZHAI^*

BIOCELL, Vol.45, No.4, pp. 933-942, 2021, DOI:10.32604/biocell.2021.014280

Abstract The present study aimed to clarify the role of SENEX in malignant cell proliferation in diffuse large B-cell lymphoma (DLBCL). 22 DLBCL patients (6 newly diagnosed cases, 7 cases at complete remission, and 9 relapsed cases) were included in the study. Our results indicated that both SENEX gene and protein were significantly increased in peripheral blood mononuclear cells (PBMCs) and tumor cells of relapsed DLBCL patients, accompanied by overexpression of p21, p16, and phosphorylated retinoblastoma (Rb). Silencing the SENEX gene in a DLBCL cell line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1… More >

Rabie A. Ramadan^1,2,*, Bassam W. Aboshosha³, Kusum Yadav¹, Ibrahim M. Alseadoon¹, Munawar J. Kashout¹, Mohamed Elhoseny^4,5

CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 3563-3579, 2021, DOI:10.32604/cmc.2021.015519

Abstract With the new era of the Internet of Things (IoT) technology, many devices with limited resources are utilized. Those devices are susceptible to a significant number of new malware and other risks emerging rapidly. One of the most appropriate methods for securing those IoT applications is cryptographic algorithms, as cryptography masks information by eliminating the risk of collecting any meaningful information patterns. This ensures that all data communications are private, accurate, authenticated, authorized, or non-repudiated. Since conventional cryptographic algorithms have been developed specifically for devices with limited resources; however, it turns out that such algorithms are not ideal for IoT… More >