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Search Results (9)
  • Open Access


    The Downregulation of miR-200c Promotes Lactate Dehydrogenase A Expression and Non-Small Cell Lung Cancer Progression

    Wei Lei1, Wang Kang1, Yang Nan, Zhang Lei, Li Zhongdong, Li Demin, Sun Lei, Huang Hairong

    Oncology Research, Vol.26, No.7, pp. 1015-1022, 2018, DOI:10.3727/096504018X15151486241153

    Abstract This study was aimed to investigate the function and mechanism of microRNA-200c (miR-200c) in the progression of non-small cell lung cancer (NSCLC). A total of 76 patients diagnosed as having NSCLC were enrolled in this study. The expression level of miR-200c in NSCLC tissues and cell lines was investigated using the quantitative real-time polymerase chain reaction (RT-qPCR) method. We found that the expression of miR- 200c was significantly reduced in NSCLC tissues and cell lines compared with normal lung tissues and the human bronchial epithelial cell line. Overexpression of miR-200c using the miR-200c mimic significantly… More >

  • Open Access


    miR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation

    Liang Li*1, Huijuan Liu*1, Lianjiang Du, Pan Xi*, Qian Wang*, Yanqin Li, Di Liu§

    Oncology Research, Vol.26, No.4, pp. 547-556, 2018, DOI:10.3727/096504017X15016337254605

    Abstract MicroRNA dysregulation contributes to malignant progression, dissemination, and profound treatment resistance in multiple cancers. miR-449a is recognized as a tumor suppresser. However, the roles of miR-449a in lung cancer initiation and progression are largely unknown. Our study aims to investigate the roles and underlying mechanism of miR-449a in modulating sensitivity to ionizing radiation (IR) in non-small cell lung cancer (NSCLC). Lung cancer cells were transfected with miR-449a mimics or negative control and exposed to IR; the levels of target protein, glycolysis, cell viability, apoptosis, and DNA damage were examined. miR-449a was suppressed in lung cancer… More >

  • Open Access


    Tunable Hydrophilicity of Poly(ethyl lactate acrylate-coacrylic acid)

    M. Purushothaman1, P. Santhana Gopala Krishnan1,2,*, S. K. Nayak1,2

    Journal of Renewable Materials, Vol.3, No.4, pp. 292-301, 2015, DOI:10.7569/JRM.2015.634114

    Abstract Four copolymers of poly(ethyl lactate acrylate-co-acrylic acid) were prepared by the solution polymerization technique by varying the comonomer content from 0.2 to 0.8 mole percent. The copolymers were characterized by FT-IR, 1H-NMR and proton decoupled 13C-NMR spectroscopic techniques. The reactivity ratio of ethyl lactate acrylate (ELA) and acrylic acid (AA) was calculated using the Fineman-Ross method and the values were found to be 0.101 and 0.186, respectively, indicating the formation of an alternating copolymer. From the wide-angle X-ray diffraction studies (WAXD), the average molecular interchain spacing () was calculated from the 2θ value of amorphous halo at… More >

  • Open Access


    Lactate Maintains BCR/Abl Expression and Signaling in Chronic Myeloid Leukemia Cells Under Nutrient Restriction

    Angela Silvano*†1, Giulio Menegazzi*1, Silvia Peppicelli*1, Caterina Mancini*, Alessio Biagioni*, Alessandro Tubita*, Ignazia Tusa*, Jessica Ruzzolini*, Matteo Lulli*, Elisabetta Rovida*, Persio Dello Sbarba*

    Oncology Research, Vol.29, No.1, pp. 33-46, 2021, DOI:10.3727/096504022X16442289212164

    Abstract This study was directed to deepen the effects of nutrient shortage on BCR/Ablprotein expression and signaling in chronic myeloid leukemia (CML) cells. The backbone of the study was cell culture in medium lacking glucose, the consumption of which we had previously shown to drive BCR/Ablprotein suppression, and glutamine, the other main nutrient besides glucose. In this context, we focused on the role of lactate, the main by-product of glucose metabolism under conditions of rapid cell growth, in particular as a modulator of the maintenance of CML stem/progenitor cell potential, a crucial determinant of disease course More >

  • Open Access


    Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer


    BIOCELL, Vol.45, No.6, pp. 1585-1599, 2021, DOI:10.32604/biocell.2021.017016

    Abstract Propofol, a common intravenous anesthetic used in clinical, has been shown to regulate cells proliferation, inflammation, angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer. However, the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown. The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer (CRC). Scratches assay, Transwell assay were used to detect colon cells migration and invasion. Real-time Quantitative Polymerase Chain Reaction (RT-qPCR), Western blotting were utilized to detect… More >

  • Open Access


    Lactate reloaded–reevaluation of the importance of lactate monitoring in the management of adult sepsis in the emergency department


    BIOCELL, Vol.45, No.3, pp. 445-449, 2021, DOI:10.32604/biocell.2021.014754

    Abstract For about a quarter of a century, monitoring lactate levels and/or lactate clearance has been an unquestionable cornerstone in sepsis management. The elevated lactate level appeared to be an independent predictor of mortality, and the consequent metabolic acidosis was thought to explain a number of pathophysiological changes seen in septic shock. Recent physiological and clinical findings seem to challenge the adverse role of lactic acidosis in sepsis. Evidence suggests that lactate levels are not necessarily directly proportional to either tissue or cellular hypoxia, and conversely, despite high lactate levels, increased peripheral tissue oxygen pressure can… More >

  • Open Access


    Cerebral tissue oxygenation index and lactate at 24 hours postoperative predict survival and neurodevelopmental outcome after neonatal cardiac surgery

    Safwat A. Aly1, David Zurakowski2, Penny Glass3, Kami Skurow-Todd4, Richard A. Jonas5, Mary T. Donofrio4

    Congenital Heart Disease, Vol.12, No.2, pp. 188-195, 2017, DOI:10.1111/chd.12426

    Abstract Importance: There are no well-established noninvasive biomarkers for identifying patients at risk for poor outcome after surgery for congenital heart disease. Few studies have assessed prognostic accuracy of cerebral tissue oxygenation index (cTOI) measured by near infrared spectroscopy (NIRS).
    Objective: To assess the utility of noninvasive NIRS monitoring as a predictor of outcomes after neonatal cardiac surgery through measurement of cTOI. To examine the utility of noninvasive NIRS monitoring in combination with lactate concentration and inotropic score in prediction of outcomes after neonatal cardiac surgery.
    Design: Prospective longitudinal cohort study.
    Setting: Operating room and cardiac intensive care unit, Children’s… More >

  • Open Access

    Synthesis of Methyl Lactate from Glycerol Using Sn-Beta Zeolite

    Wenjie Dong, Chenlu Wang, Minyan Gu, Long Yang, Zheng Shen*, Yalei Zhang*

    Journal of Renewable Materials, Vol.5, Suppl.1, pp. 22-30, 2017, DOI:10.7569/JRM.2017.634126

    Abstract Lactic acid can not only be used to produce multiple chemicals, but can also be the building block for biodegradable and biocompatible polylactic acid identified as a renewable resource. As a by-product in biodiesel production, the glycerol yield increases with a rapid expansion of biodiesel. However, in the chemical and environmental fields it is still a great challenge to produce lactic acid or methyl lactate from glycerol. Herein, Sn-Beta zeolite was prepared through solid-state ion exchange (Sn-Beta SSIE) and was tested for base-free one-pot catalytic selective oxidation of glycerol into methyl lactate in methanol. The More >

  • Open Access


    Effect of Sepiolite Content on Hydrophilicity and Thermal Stability of Poly(butyl lactate methacrylate)

    M. Purushothaman†,1, P. Santhana Gopala Krishnan1,2*, S. K. Nayak1,2

    Journal of Renewable Materials, Vol.5, No.5, pp. 363-370, 2017, DOI:10.7569/JRM.2017.634128

    Abstract In the present work, the hydrophilicity and thermal behavior of nanocomposites of poly(butyl lactate methacrylate) were investigated using different weight percent of sepiolite. These nanocomposites were prepared by solution casting method. X-ray diffraction (XRD) studies indicated that the increase in sepiolite content decreased the average molecular interchain spacing () values from 7.18 to 6.23 Å in nanocomposites. Apart from the amorphous halo peak of nanocomposites, the appearance of crystalline peak at 7.41° was due to the d110 plane of sepiolite. Surface morphology of nanocomposites was studied using scanning electron microscopy (SEM) and transmission electron microscopy More >

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