ZHEN JIA1,2,#, ZHENGTING QIAN1,2,#, YONG TANG2, XIANG LI2, YAN SHI2, HENG XIN1,2, YOUWU FAN1,2,*, HEMING WU2,*
Oncology Research, Vol.29, No.2, pp. 105-117, 2021, DOI:10.32604/or.2022.03536
Abstract Glioma is a general malignant tumor with a dismal prognosis. Long noncoding RNAs (lncRNAs) have been
implicated in the initiation and processes of tumors. An investigation of the GEPIA database revealed that long
noncoding RNA WEE2 antisense RNA 1 (WEE2-AS1) is upregulated in glioma tissues compared to normal brain
tissues, and validation with quantitative real-time polymerase chain reaction (qRT–PCR) revealed that WEE2-AS1
expression was consistent with the database prediction. Fluorescence in situ hybridization (FISH) assays revealed that
WEE2-AS1 was localized primarily in the cytoplasm. Clone formation experiment and EDU assay were used to detect
cell proliferation ability, and Transwell assay… More >
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