GUANQIONG HU1, RISHENG HUANG2, LUELUE LU1, QINSHI PAN3, XIAOXIN CHEN1,*
BIOCELL, Vol.47, No.6, pp. 1243-1251, 2023, DOI:10.32604/biocell.2023.027763
Abstract Background: Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that plays a central role in the
pathogenesis of idiopathic pulmonary fibrosis (IPF). While previous studies have revealed a cross-talk between vitamin D
and TGF-β1 signaling, it is still unclear how they interact with each other to regulate the progression of IPF. Methods: In
this work, we searched for a novel mediator of TGF-β1 activity in lung fibroblasts and examined its regulation by vitamin
D. In addition, we investigated the mechanism underlying the interaction between vitamin D and TGF-β1 signaling in
lung fibroblast activation. Bioinformatic analysis was performed to identify TGF-β1… More >
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