Shujie Yin¹, Zong Li¹, Wen-Bin Ou^1,2,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069049 - 30 December 2025

Abstract Ferroptosis is an iron-dependent, excessive lipid peroxidation-driven form of regulated cell death. The core mechanisms of ferroptosis include lipid peroxidation cascade, System X_c⁻-glutathioneglutathione peroxidase 4 axis, iron and lipid metabolism chaos, the NAD(P)Hferroptosis suppressor protein 1—ubiquinone axis, and GTP cyclohydrolase 1 tetrahydrobiopterin-dihydrofolate reductase axis. Cuproptosis is triggered by copper ions and involves ferredoxin 1-mediated aggregation of lipoylated proteins, differing fundamentally from ferroptosis. Both ferroptosis and cuproptosis exhibit dual roles (promote or inhibit) in cancers. And the sensitivity of different cancer types to ferroptosis varies, which may depend on special metabolic signatures (e.g., E-cadherin loss causes epithelial–mesenchymal More > Graphic Abstract

Malvinder Singh Bali¹, Weiwei Jiang^2,*, Saurav Verma³, Kanwalpreet Kour⁴, Ashwini Rao³

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-19, 2026, DOI:10.32604/cmc.2025.070866 - 09 December 2025

Abstract In recent years, Blockchain Technology has become a paradigm shift, providing Transparent, Secure, and Decentralized platforms for diverse applications, ranging from Cryptocurrency to supply chain management. Nevertheless, the optimization of blockchain networks remains a critical challenge due to persistent issues such as latency, scalability, and energy consumption. This study proposes an innovative approach to Blockchain network optimization, drawing inspiration from principles of biological evolution and natural selection through evolutionary algorithms. Specifically, we explore the application of genetic algorithms, particle swarm optimization, and related evolutionary techniques to enhance the performance of blockchain networks. The proposed methodologies More >

Jia Yan Lim^1,2, Siti Madiha Muhammad Amir³, Roslan Yahya³, Marta Peña Fernández², Tze Chuen Yap^1,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-19, 2026, DOI:10.32604/cmc.2025.070707 - 09 December 2025

Abstract Additive Manufacturing, also known as 3D printing, has transformed conventional manufacturing by building objects layer by layer, with material extrusion or fused deposition modeling standing out as particularly popular. However, due to its manufacturing process and thermal nature, internal voids and pores are formed within the thermoplastic materials being fabricated, potentially leading to a decrease in mechanical properties. This paper discussed the effect of printing parameters on the porosity and the mechanical properties of the 3D printed polylactic acid (PLA) through micro-computed tomography (microCT), computational image analysis, and Charpy impact testing. The results for both… More >

Yeasul Kim¹, Chaeeun Won¹, Hwankuk Kim^2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-28, 2026, DOI:10.32604/cmc.2025.069608 - 10 November 2025

Abstract With the increasing emphasis on personal information protection, encryption through security protocols has emerged as a critical requirement in data transmission and reception processes. Nevertheless, IoT ecosystems comprise heterogeneous networks where outdated systems coexist with the latest devices, spanning a range of devices from non-encrypted ones to fully encrypted ones. Given the limited visibility into payloads in this context, this study investigates AI-based attack detection methods that leverage encrypted traffic metadata, eliminating the need for decryption and minimizing system performance degradation—especially in light of these heterogeneous devices. Using the UNSW-NB15 and CICIoT-2023 dataset, encrypted and… More >

Xiaohu Song¹, Zhiliang Zhu^2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-19, 2026, DOI:10.32604/cmc.2025.068930 - 10 November 2025

Abstract Vulnerabilities are a known problem in modern Open Source Software (OSS). Most developers often rely on third-party libraries to accelerate feature implementation. However, these libraries may contain vulnerabilities that attackers can exploit to propagate malicious code, posing security risks to dependent projects. Existing research addresses these challenges through Software Composition Analysis (SCA) for vulnerability detection and remediation. Nevertheless, current solutions may introduce additional issues, such as incompatibilities, dependency conflicts, and additional vulnerabilities. To address this, we propose Vulnerability Scan and Protection (), a robust solution for detection and remediation vulnerabilities in Java projects. Specifically, builds… More >

Xiaoyan Zhuo¹, Yukun Ji¹, Yatao Ren^1,*, Xuehui Wang², Hong Qi¹

Frontiers in Heat and Mass Transfer, Vol.23, No.6, pp. 1701-1720, 2025, DOI:10.32604/fhmt.2025.074045 - 31 December 2025

Abstract Flow and heat transfer characteristics during droplet impact on hot walls are pivotal for elucidating the mechanisms of spray cooling and exploring pathways for heat transfer enhancement. When the wall temperature exceeds the Leidenfrost point, a vapor film forms between the droplet and the wall, rendering the heat transfer process highly complex. Furthermore, for droplet impact on curved walls, the presence of curvature introduces additional factors that modify the spreading behavior of the droplet and necessitate in-depth analysis. Therefore, this work investigates the flow and heat transfer dynamics of droplet impact on hot planes and… More >

Maxwell Sandberg^1,*, Mark Xu¹, Randall Bissette¹, Jacob Malakismail², Niara East³, Robenson Nguyen⁴, Jackson Nowatzke¹, Robert Stratta⁵, Dean Assimos^1,6, Colin Kleinguetl¹

Canadian Journal of Urology, Vol.32, No.6, pp. 633-641, 2025, DOI:10.32604/cju.2025.069091 - 30 December 2025

Abstract Objectives: Donor-gifted nephrolithiasis—the presence of a stone in a donor kidney at the time of transplantation—is rare. Research is limited, and no consensus high-quality evidence guidelines exist, leaving selection criteria and management to individual provider discretion. We aimed to estimate the frequency and analyze patient and graft outcomes of deceased donor (DD) transplant recipients with stones in their kidneys at Wake Forest Baptist Medical Center. Methods: All DD renal transplants or patients receiving most of their care postoperatively after DD renal transplantation at our institution from 1979 to 2025 were reviewed. Stones were considered donor-gifted… More >

John Hordines¹, Shirley Ge², Dima Raskolnikov¹, Alexander C. Small¹, Kara L. Watts^1,*

Canadian Journal of Urology, Vol.32, No.6, pp. 551-560, 2025, DOI:10.32604/cju.2025.065988 - 30 December 2025

Abstract Background: The healthcare industry contributes nearly 5% of worldwide carbon emissions. In an effort to mitigate this impact, urology practices can take steps to reduce their carbon footprints. We conducted a systematic review which aimed to summarise the current literature on the environmental impact of urologic-related care. Methods: A systematic literature review evaluating the impact of urologic procedures, telehealth and conferences/interviews was conducted on PubMed and Cochrane databases using a Boolean search strategy and the following search terms: urology, planetary health, environmental impact, carbon emissions, carbon footprint, and waste. Full-text articles published in English were… More >

Masefako Andronica Gumani^*

Journal of Psychology in Africa, Vol.35, No.6, pp. 807-814, 2025, DOI:10.32604/jpa.2025.065776 - 30 December 2025

Abstract This study explored law enforcement members’ empathetic engagements with primary survivors of trauma. Informants were 15 South African Police Service members from a rural district of the Limpopo (females = 26.6%; constables = 13.3%). Unstructured open-ended and follow-up telephone interviews, field notes, and diaries were used as data-collection methods. Data were analysed following the Interpretative Phenomenological Analysis guidelines. Emergent themes indicated that law enforcement members engage in three types of empathy, namely affective, cognitive, and cognitive-affective empathy when called upon to help survivors of trauma. Their affective empathy involved police members’ emotional connection with the More >

Md Salah Uddin^*

Journal of Polymer Materials, Vol.42, No.4, pp. 1051-1073, 2025, DOI:10.32604/jpm.2025.070688 - 26 December 2025

Abstract Carbon fiber-reinforced composites (CFRCs) have a wide range of applications in the aerospace, automotive, and energy sectors. A higher specific strength-to-weight ratio is desired in high-performance applications. The failure mechanism of CFRCs involves multiscale phenomena, such as failure that can occur at the matrix, fibers, interface, layers, lamina, and laminates. When an impactor hits the CFRCs, the design involves analyzing each of these stages to prevent failure and optimize the properties of CFRCs under various loading conditions. A numerical model was employed to predict the fracture toughness of CFRCs with varying weight fractions and orientations.… More >