Dordaneh Sugano¹, Abhinav Sidana^1,2, Brian Calio¹, Kaitlan Cobb¹, Baris Turkbey³, Peter A. Pinto¹

Canadian Journal of Urology, Vol.24, No.4, pp. 8876-8882, 2017

Abstract Introduction: Although prostate cancer is the most common non-cutaneous cancer in men, it is traditionally diagnosed with a non-targeted, systematic transrectal ultrasound prostate biopsy (TRUS-Bx). This technique has been demonstrated to both under-detect clinically significant (CS) cancer and over-detect clinically insignificant cancer, and performs poorly in patients with a prior negative biopsy. With recent advances in MRI technology, most prominently the advent of multiparametric MRI, MRI-targeted prostate biopsy (MRI-TB) has been gaining favor as a more accurate alternative to TRUS-Bx. In this review, we attempt to summarize the current literature on MRI-TB and to determine if… More >

Cory Noel^1,2

Congenital Heart Disease, Vol.12, No.5, pp. 627-629, 2017, DOI:10.1111/chd.12501

Abstract Myocardial ischemia is an insult that is primarily thought of in an adult population. However, there are several congenital and acquired cardiac lesions that may lead to myocardial ischemia in a pediatric population. One of the prominent congenital lesions is anomalous aortic origin of a coronary artery (AAOCA). Anomalous aortic origin of a coronary artery is one of the leading causes sudden cardiac death in pediatric and young adult patients, and thus the assessment of myocardial perfusion is of the utmost importance. Over the past decade, pharmacologic stress MRI has proven to be a highly More >

Elise D. Pieterman^1,2, Ricardo P. J. Budde², Danielle Robbers-Visser^1,2, Ron T. van Domburg³, Willem A. Helbing^1,2

Congenital Heart Disease, Vol.12, No.5, pp. 561-569, 2017, DOI:10.1111/chd.12484

Abstract Objective: Follow-up of right ventricular performance is important for patients with congenital heart disease. Cardiac magnetic resonance imaging is optimal for this purpose. However, observerdependency of manual analysis of right ventricular volumes limit its use. Knowledge-based reconstruction is a new semiautomatic analysis tool that uses a database including knowledge of right ventricular shape in various congenital heart diseases. We evaluated whether knowledge-based reconstruction is a good alternative for conventional analysis.
Design: To assess the inter- and intra-observer variability and agreement of knowledge-based versus conventional analysis of magnetic resonance right ventricular volumes, analysis was done by two observers… More >

Matthew J. Lewis¹, Elizabeth Hecht², Jonathan Ginns¹, Joshua Benton², Martin Prince², Marlon S. Rosenbaum¹

Congenital Heart Disease, Vol.12, No.2, pp. 153-158, 2017, DOI:10.1111/chd.12422

Abstract Background: The progression of hepatic disease in adult Fontan patients is not well understood. They reviewed the experience with serial cardiac MRIs (CMR) in adult Fontan patients to determine if hepatic anatomic markers of prolonged Fontan exposure were present and if clinical predictors of progressive hepatic congestion could be identified.
Methods and Results: A retrospective cohort study of all adult Fontan patients who had undergone at least two CMRs was performed. Hepatic dimensions, inferior vena cava (IVC) size, right hepatic vein (RHV) size and spleen diameter were determined from images acquired at the time of clinically guided… More >

Benjamin H. Goot, Sonali Patel, Brian Fonseca

Congenital Heart Disease, Vol.12, No.1, pp. 84-90, 2017

Abstract Objective: When imaging the lower airway by MRI, the traditional technique turbo spin echo (TSE) results in high quality 2D images, however planning and acquisition times are lengthy. An alternative, delayed volume interpolated breath-holds examination (VIBE), is a 3D gradient echo technique that produces high spatial resolution imaging of the airway in one breath-hold. The objective of this study is to retrospectively evaluate the accuracy of lower airway measurements obtained by delayed VIBE when compared to TSE.
Design: Patients with congenital heart disease who underwent a cardiac MRI (CMR) that included a delayed VIBE sequence from 5/2008… More >

Richard J. Dobson¹, Ify Mordi², Mark H. Danton¹, Niki L. Walker¹, Hamish A. Walker¹, Nikolaos Tzemos²

Congenital Heart Disease, Vol.12, No.1, pp. 58-66, 2017

Abstract Objective: Myocardial fibrosis has been associated with poorer outcomes in tetralogy of Fallot, however only a handful of studies have assessed its significance in the current era. Our aim was to quantify the amount of late gadolinium enhancement in both the LV and RV in a contemporary cohort of adults with surgically repaired tetralogy of Fallot, and assess the relationship with adverse clinical outcomes.
Design: Single centre cohort study
Setting: National tertiary referral center
Patients: One hundred fourteen patients with surgically repaired tetralogy of Fallot with median age 29.5 years (range 17.5-64.2). Prospective follow-up for mean 2.4 years (SD… More >

Dalin Tang^1,*,2, Heng Zuo^2,*, Chun Yang², Zheyang Wu², Xueying Huang³, Rahul H. Rathod⁴, Alexander Tang⁴, Kristen L. Billiar⁵, Tal Geva⁴

Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 137-151, 2017, DOI:10.3970/mcb.2017.014.137

Abstract Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricle failure. Comparing TOF patients with healthy people may provide information to address this challenge. Cardiac magnetic resonance (CMR) data were obtained from 16 TOF patients (patient group, PG) and 6 healthy volunteers (healthy group, HG). At begin-of-ejection, better patient group (n=5, BPG) stress was very close to HG stress (54.7±38.4 kPa vs. 51.2±55.7 kPa, p=0.6889) while worse patient group (n=11, WPG) stress was 84% higher than HG stress (p=0.0418). Stress may be used as an indicator to differentiate More >

Ravikumar Gurusamy¹, Dr Vijayan Subramaniam²

CMC-Computers, Materials & Continua, Vol.53, No.2, pp. 91-108, 2017, DOI:10.3970/cmc.2017.053.091

Abstract A new method for the denoising, extraction and tumor detection on MRI images is presented in this paper. MRI images help physicians study and diagnose diseases or tumors present in the brain. This work is focused towards helping the radiologist and physician to have a second opinion on the diagnosis. The ambiguity of Magnetic Resonance (MR) image features is solved in a simpler manner. The MRI image acquired from the machine is subjected to analysis in the work. The real-time data is used for the analysis. Basic preprocessing is performed using various filters for noise More >

Dalin Tang¹, Chun Yang², Satya Atluri³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.18, No.3, pp. 67-68, 2011, DOI:10.3970/icces.2011.018.067

Abstract Cardiovascular disease is the leading cause of death worldwide. Many victims of the disease died suddenly without prior symptoms. It is a great challenge for clinicians and researchers to develop screening techniques and assessment methodologies to identify those patients for early treatment and prevention of the fatal clinical event. Considerable effort has been devoted investigating mechanisms governing atherosclerotic plaque progression and rupture [Friedman, Bargeron, Deters, Hutchins and Mark (1987); Friedman and Giddens (2005); Giddens, Zarins, Glagov, S. (1993); Ku, Giddens, Zarins and Glagov (1985); Gibson et al. (1993); Liu and Tang (2010); Stone et al.… More >

Chun Yang^1,2, Dalin Tang², Satya Atluri³

CMES-Computer Modeling in Engineering & Sciences, Vol.72, No.1, pp. 53-78, 2011, DOI:10.3970/cmes.2011.072.053

Abstract Previously, we introduced a computational procedure based on three-dimensional meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Structure-only models were used in our previous report. In this paper, fluid-stricture interaction (FSI) was added to improve on prediction accuracy. One participating patient was scanned three times (T1, T2, and T3, at intervals of about 18 months) to obtain plaque progression data. Blood flow was assumed to laminar, Newtonian, viscous and incompressible. The Navier-Stokes equations with arbitrary Lagrangian-Eulerian (ALE) formulation… More >