LUIS MANUEL GONZáLEZ-RODRíGUEZ¹, LUIS MIGUEL JUáREZ-SALCEDO^1,*, JAVIER LOSCERTALES¹, EVA ARRANZ¹, JIMENA CANNATA-ORTIZ¹, JAVIER ORTIZ¹, MARIA JOSé LóPEZ DE LA OSA¹, ADRIáN ALEGRE¹, SAMIR DALIA^2,*

Oncology Research, Vol.33, No.3, pp. 505-517, 2025, DOI:10.32604/or.2025.058175 - 28 February 2025

Abstract T-prolymphocytic leukemia is a rare and aggressive hematological malignancy characterized by the clonal proliferation of mature lymphoid T-cells. The pathogenesis of T-PLL is closely linked to specific chromosomal abnormalities, primarily involving the proto-oncogene T-cell leukemia/lymphoma 1 gene family. Recent advancements in molecular profiling have identified additional genomic aberrations, including those affecting the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. This case report presents a patient with T-prolymphocytic leukemia whose cytogenetic and molecular analysis revealed a t(X;14)(q28;q11.2) translocation and a STAT5B mutation. Here, we aim to review the genetic and molecular underpinnings of T-prolymphocytic More >

ELHAM SHAKIBA¹, SETI BOROOMAND², SIMA KHERADMAND KIA³, MEHDI HEDAYATI^4,*

Oncology Research, Vol.32, No.6, pp. 1011-1019, 2024, DOI:10.32604/or.2024.049235 - 23 May 2024

Abstract This review aimed to describe the inculpation of microRNAs (miRNAs) in thyroid cancer (TC) and its subtypes, mainly medullary thyroid carcinoma (MTC), and to outline web-based tools and databases for bioinformatics analysis of miRNAs in TC. Additionally, the capacity of miRNAs to serve as therapeutic targets and biomarkers in TC management will be discussed. This review is based on a literature search of relevant articles on the role of miRNAs in TC and its subtypes, mainly MTC. Additionally, web-based tools and databases for bioinformatics analysis of miRNAs in TC were identified and described. MiRNAs can… More > Graphic Abstract

Kaiyue Wang¹, Jian Gao^1,2,*, Xinyan Lei¹

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 619-638, 2023, DOI:10.32604/iasc.2023.036701 - 29 April 2023

Abstract Traffic characterization (e.g., chat, video) and application identification (e.g., FTP, Facebook) are two of the more crucial jobs in encrypted network traffic classification. These two activities are typically carried out separately by existing systems using separate models, significantly adding to the difficulty of network administration. Convolutional Neural Network (CNN) and Transformer are deep learning-based approaches for network traffic classification. CNN is good at extracting local features while ignoring long-distance information from the network traffic sequence, and Transformer can capture long-distance feature dependencies while ignoring local details. Based on these characteristics, a multi-task learning model that… More >

Madiraju Sirisha^1,*, P. Abdul Khayum²

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1627-1641, 2023, DOI:10.32604/iasc.2023.025980 - 19 July 2022

Abstract In the digital era, the Narrowband Internet of Things (Nb-IoT) influences the massive Machine-Type-Communication (mMTC) features to establish secure routing among the 5G/6G mobile networks. It supports global coverage to the low-cost IoT devices distributed in terrestrial networks. Its key traffic characteristics include robust uplink, moderate data rate/device, extremely high energy efficiency, prolonging device lifetime, and Quality of Service (QoS). This paper proposes a Deep Reinforcement Learning (DRL) combined software-defined air interface algorithm applied on the switching system, satisfying the user requirement and enabling them with the network resources to extend quality of service by More >

Najib Ahmed Mohammed¹, Ali Mohammed Mansoor^1,*, Rodina Binti Ahmad¹, Saaidal Razalli Bin Azzuhri²

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 573-592, 2022, DOI:10.32604/cmc.2022.020462 - 03 November 2021

Abstract Mission critical Machine-type Communication (mcMTC), also referred to as Ultra-reliable Low Latency Communication (URLLC), has become a research hotspot. It is primarily characterized by communication that provides ultra-high reliability and very low latency to concurrently transmit short commands to a massive number of connected devices. While the reduction in physical (PHY) layer overhead and improvement in channel coding techniques are pivotal in reducing latency and improving reliability, the current wireless standards dedicated to support mcMTC rely heavily on adopting the bottom layers of general-purpose wireless standards and customizing only the upper layers. The mcMTC has… More >

Yangjing Chen, Shaoqiang Zhang, Ruimin Zhao, Qian Zhao, Ting Zhang

Oncology Research, Vol.25, No.8, pp. 1215-1222, 2017, DOI:10.3727/096504016X14791715355957

Abstract Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer derived from parafollicular C cells in the thyroid gland. It has great interest as a research focus because of its unusual genetic, clinical, and prognostic characteristics. However, the pathogenesis in MTC is not completely clear. We investigated the role of miR- 9-3p and bladder cancer-associated protein (BLCAP) in MTC TT cells. First, miR-9-3p expression was upregulated in human MTC tissues and TT cells and compared to the control by RT-PCR. Flow cytometric analysis indicated that the cell cycle progression in TT cells was significantly inhibited by the… More >

Anqi Yin^*†1, Chengguo Wang^‡1, Jiachen Sun^*1, Jianjun Gao^§, Liang Tao^†, Xilin Du^‡, Huadong Zhao^‡, Jiandong Yang^§, Yan Li^*†

Oncology Research, Vol.23, No.1-2, pp. 43-51, 2015, DOI:10.3727/096504015X14452563486093

Abstract Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) had a significantly lower expression in MTC compared with normal thyroid tissue. However, the function of NDRG2 in MTC oncogenesis is largely unknown. In this study, we found that overexpression of NDRG2 inhibited the proliferation of TT cells (human medullary thyroid carcinoma cells) in vitro and suppressed the development of MTC… More >