YAQUN HONG1,2, BO WAN3, XIAOFAN LI1,4,*
BIOCELL, Vol.44, No.2, pp. 237-246, 2020, DOI:10.32604/biocell.2020.08887
Abstract Most studies focus on the adaptive immune cells in the GVHD pathogenesis, while little is known about innate
immune cells in GVHD occurrence and development, especially macrophages. Meanwhile, a higher incidence of graft
versus host disease (GVHD) is also found in the elderly patients. Though advances have been made in the
modification of macrophages influenced by the inflamm-ageing, there is still no review on the role of macrophages in
GVHD and the association between GVHD and the altered macrophages by inflamm-ageing. In this review, we focus
on the potential age-related modifications of macrophage in GVHD, which contributes to the change… More >
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