Yiwei Hao^1,#, Yaodong Ping^2,#, Yan Yang³, Cheng Qu³, Yuan Chen¹, Xueyan Jiang¹, Rong Fu¹, Hailong Zhao^4,*, Lei Yu^4,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2025.074863 - 21 April 2026

Abstract Myocardial ischemia, a core pathological process underlying diverse cardiovascular diseases such as coronary artery disease, poses a severe threat to global human health by frequently leading to acute myocardial infarction, heart failure, and even sudden cardiac death. A comprehensive understanding of its intricate underlying pathogenic mechanisms is not only crucial for developing effective therapeutic strategies but also essential for accelerating the translation of basic research findings into clinical practice. However, the complex regulatory networks that drive myocardial ischemia remain to be systematically clarified. These networks encompass the intricate interactions among multiple pathological processes, including energy… More >

Yiming Chen^1,2, Qiong Luo^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.077896 - 31 March 2026

Abstract Lycium ruthenicum Murray (black goji berry) is an economically important crop rich in anthocyanins, however, the post-transcriptional regulatory mechanisms underlying anthocyanin accumulation in its fruits are unknown. Here, we used whole-transcriptome sequencing to identify differentially expressed circRNAs and lncRNAs in black goji (BS4) and white goji (WS4). Furthermore, we analyzed the regulatory networks of the key ncRNAs and their target genes by combining targeted phytohormone metabolomics with molecular docking technology. We found that the circRNA plantcirc_001165 synergistically upregulated the flavonoid biosynthesis gene LrHCT with the lncRNA MSTRG.28703 to promote anthocyanin accumulation. However, MSTRG.28703 repressed LrZOX1 expression, leading More >

Xiao Wang^*, E Liang, Xiaohui Song, Deyan Li

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.075656 - 31 March 2026

Abstract Three-year-old Panax japonicus was exposed to elevated CO₂ concentrations using open-top chambers: ambient CO₂ (aCO₂), moderately elevated (e1CO₂, 550 μmol/mol), and highly elevated (e2CO₂, 750 μmol/mol). Gas exchange parameters, photosynthetic pigments, sugar accumulation, and total saponin content were measured to assess the effects of CO₂ enrichment on photosynthesis, sugar metabolism, and saponin biosynthesis. The e1CO₂ treatment significantly increased net photosynthetic rate (by 17.22% at 36 days and 69.62% at 92 days), chlorophyll a content, and soluble sugar, sucrose, and starch accumulation. Key sugar metabolism enzymes, including sucrose phosphate synthase (SPS), also showed enhanced activity. Consequently, underground rhizome total saponins rose More >

Congwei You^1,#, Anwen Yin^2,#, Jia Xia³, Le Zhang^4,*, Xiaolei Wang^1,*, Yutong Hou^4,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.072971 - 23 March 2026

Abstract Metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD) have shown a marked global increase in prevalence, placing a substantial burden on public health and healthcare systems worldwide. Epidemiological data demonstrate a significant overlap between these two conditions, with further evidence from research identifying common pathophysiological features, such as lipid metabolism dysregulation, disrupted energy balance, and chronic systemic inflammation. Mitochondria are central to the pathophysiology of both diseases. In addition to their role in energy production, mitochondria are involved in numerous critical cellular processes, including biosynthesis, lipid metabolism, oxidative phosphorylation, signal transduction, and More >

Wubin Zhao^#, Qi Wang^#, Jun Zhang^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.076406 - 23 March 2026

Abstract Disulfidptosis is a newly identified form of regulated cell death (RCD) first described in 2023, representing a significant advance in understanding programmed cell death pathways. This unique cell death modality is characterized by abnormal intracellular accumulation of disulfide bonds and disruption of redox homeostasis, leading to cytoskeletal collapse without caspase activation. Disulfidptosis is primarily triggered by glucose deprivation in cells with high expression of solute carrier family 7 member 11 (SLC7A11). Under these conditions, insufficient NADPH supply prevents the effective reduction of accumulated cystine to cysteine, thereby inducing disulfide stress. Distinct from apoptosis, ferroptosis, cuproptosis,… More >

Yimao Wu^1,2,#, Yitong Liu^2,#, Ruowei Sun^3,#, Yiyuan Zhang², Qian Zhang^4,*, Chen Li^5,*, Mengyao Li^1,6,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.075012 - 24 February 2026

Abstract Tumor metabolic reprogramming is a core hallmark of cancer, characterized by pathways such as aerobic glycolysis, aberrant lipid metabolism, and glutaminolysis that support rapid proliferation and immunosuppressive microenvironments. Circular RNAs (circRNAs) are highly stable, evolutionarily conserved non-coding RNAs that have emerged as critical modulators of these metabolic shifts. This review aims to systematically elucidate the roles and mechanisms of circRNAs in reprogramming tumor metabolism, and to discuss their clinical potential as biomarkers and therapeutic targets. Through mechanisms including miRNA sponging, protein interactions, regulation of mitochondrial dynamics, and modulation of metabolic enzymes, circRNAs influence key metabolic… More >

Weiping Yang^1,#, Wei Xiao^2,#, Wenhao Xu^3,#, Lijun Ren¹, Xian Li¹, Junhua Yu¹, Ronghua Wang^4,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.071122 - 24 February 2026

Abstract Background: Tertiary lymphoid structures (TLSs) promote antitumor immunity and predict favorable immunotherapy outcomes in breast cancer. The study aimed to investigate how Tryptophan 2,3-dioxygenase (TDO2)-associated tryptophan metabolism influences TLS maturation and B cell class switching in breast cancer. Methods: Bulk transcriptomic data from The Cancer Genome Atlas-Breast Invasive Carcinoma (TCGA-BRCA, n = 1055) were analyzed using Gene Set Variation Analysis (GSVA)–based metabolic scoring, immune deconvolution, and TLS quantification. Single-cell RNA sequencing (scRNA-seq, n = 26) and spatial transcriptomics (n = 1) were applied to map TDO2 expression and TLS spatial organization. Validation was performed by immunohistochemistry (n… More >

Min Dong^1,#, Zongchang Song^2,#, Xiaohui Lu^1,3,#, Minxue Lu^4,*, Chen Zhong^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.068508 - 24 February 2026

Abstract Background: Gastric cancer (GC) remains highly lethal, with metabolic reprogramming as a key hallmark. This study explores Centromere Protein F (CENPF)’s role in GC pathogenesis, specifically its regulation of glutamine metabolism. Methods: The Cancer Genome Atlas–Stomach Adenocarcinoma (TCGA-STAD), GSE19826, and GSE27342 datasets were analyzed by bioinformatics to identify key candidate genes in GC. The function of CENPF was assessed by flow cytometry, colony formation assays, and Cell Counting Kit-8 (CCK-8). RNA sequencing, metabolic profiling, chromatin immunoprecipitation (ChIP), western blot (WB), and luciferase reporter assay were employed to investigate the fundamental mechanisms. Results: CENPF was upregulated in GC… More >

Min Hee Kim¹, Boyoon Huh¹, Joo-Won Park^1,*, Woo-Jae Park^2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071523 - 19 January 2026

Abstract Breast cancer is one of the most prevalent malignancies among women and comprises a heterogeneous spectrum of molecular subtypes with distinct biological behaviors. Among various regulatory molecules, sphingolipids play pivotal roles in dynamically modulating fundamental cellular processes such as proliferation, apoptosis, and metastasis through metabolic interconversions, including phosphorylation, glycosylation, and the generation of sphingosine-1-phosphate. This review aims to elucidate the mechanisms through which sphingolipid metabolism orchestrates cancer cell fate and drives breast cancer progression. Particular emphasis is placed on the balance between proapoptotic ceramides and pro-survival metabolites, such as sphingosine-1-phosphate, which collectively influence tumor growth More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >