Chi Zhang1,#, Xi Huang2,#, Cheng Hu1, Bowen Tang1, Jianjie Wu1, Zhuolun Sun1, Weian Zhu1, Xiangfu Zhou1, Hengjun Xiao1,*, Hua Wang1,*
Oncology Research, Vol.33, No.9, pp. 2331-2351, 2025, DOI:10.32604/or.2025.065119
- 28 August 2025
Abstract Background: U2AF homology motif kinase 1 (UHMK1) has been associated with RNA processing and protein phosphorylation, thereby influencing tumor progression. The study aimed to explore its regulatory mechanisms and biological functions in human prostate cancer (PCa). Methods: In this study, we systematically evaluated the expression and prognostic significance of UHMK1 in public databases, followed by validation through immunohistochemistry (IHC) in PCa specimens. Both gain-of-function and loss-of-function experiments were conducted to elucidate the role of UHMK1 in vitro and in vivo. Additionally, a series of molecular and biochemical assays were performed to investigate the regulatory mechanisms underlying UHMK1… More >
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