RAHUL KUMAR SINGH^1,#, SUROJIT MANDAL^1,#, ADRIJA MOHANTA¹, RITU YADAV¹, RAJIV RANJAN KUMAR¹, RINKU KHATKAR¹, VIVEK UTTAM¹, UTTAM SHARMA¹, MANJIT KAUR RANA², MANJU JAIN³, HARDEEP SINGH TULI⁴, AKLANK JAIN^1,*

Oncology Research, Vol.33, No.3, pp. 591-604, 2025, DOI:10.32604/or.2024.050548 - 28 February 2025

Abstract Objectives: Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 (ZFAS1) in cancer development. However, the intricate interplay of ZFAS1 with miRNAs and mRNAs remains to be fully understood. Materials and methods: We followed PRISMA guidelines to retrieve and assess the available literature on the topic “ZFAS1/miRNA/mRNA axis” and “Cancer” from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of ZFAS1 and its role in survival of cancer patients along with their role in various biological functions and pathways. Results: Our literature search… More >

QI LV^1,#, GANGMIN WANG^2,#, YI HONG¹, TIANYI ZHU¹, SHUANG QIN¹, SAIFEI SUN¹, YUTING WANG¹, YAOHUA LIU¹, QING ZHANG¹, CHUNHUI MA^3,*, PEIJUN WANG^1,*

Oncology Research, Vol.33, No.2, pp. 407-420, 2025, DOI:10.32604/or.2024.047698 - 16 January 2025

Abstract Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and developing practical countermeasures for sunitinib resistance in RCC is desirable. In previous studies, we found that circAGAP1 expression was significantly upregulated in clear cell RCC (ccRCC) and was strongly associated with poor prognosis. However, the role of circAGAP1 in sunitinib resistance in ccRCC remains unclear. Methods: We used public databases for bioinformatics analysis to identify the binding targets of circAGAP1. Additionally, the effects of circAGAP1 on the proliferation, clonogenesis, apoptosis, and migration of ccRCC cells were… More > Graphic Abstract

KURT SARTORIUS^1,2,3,*, BENN SARTORIUS⁴, CHERIE WINKLER⁵, ANIL CHUTURGOON², ANNA KRAMVIS¹, PING AN⁵, WEIGANG ZHANG⁶, YUNJIE LU^3,6,7,*

BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505 - 07 November 2024

Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.10, pp. 1699-1700, 2024, DOI:10.32604/or.2024.056919 - 18 September 2024

Abstract This article has no abstract. More >

XUHUI ZHAO^1,2, XIAOMIN HUANG¹, CHUNYAN DANG², XIA WANG¹, YUJIAO QI³, HONGLING LI^2,*

Oncology Research, Vol.32, No.5, pp. 999-1009, 2024, DOI:10.32604/or.2024.046679 - 23 April 2024

Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results:… More >

BIN LI^1,2,3,#, YUCHENG SHENG^4,#, XIAOYING XU⁴, SHENGCUN WANG³, HONGYAN SONG³, JINGYUAN LI³, HAONAN JI¹, QINGHUA WANG³, XIAODI ZHOU^1,*, LONGJU QI^2,*

BIOCELL, Vol.48, No.4, pp. 601-611, 2024, DOI:10.32604/biocell.2024.047404 - 09 April 2024

Abstract Objective: Chronic kidney disease (CKD) is a progressive disorder characterized by intricate structural and functional alterations in the kidneys, attributable to diverse causative factors. Notably, the therapeutic promise of miR-145-5p in addressing renal pathologies has been discerned. This investigation seeks to elucidate the functional role of miR-145-5p in injured kidneys by subjecting human glomerular mesangial cells (HGMCs) to stimulation with Angiotensin II (AngII). Materials and Methods: Cellular viability and the levels of inflammatory mediators were evaluated utilizing Cell Counting Kit-8 (CCK-8), quantitative real-time polymerase chain reaction (qRT-PCR), and western blot methodologies, both in the presence of… More >

LEI LIU¹, NA GUO¹, XIANGLING LI², QIAN XU², RUILONG HE³, LIMIN CHENG⁴, CHUNYAN DANG³, XINYU BAI³, YIYING BAI³, XIN WANG³, QIANHUI CHEN³, LI ZHANG^3,*

Oncology Research, Vol.32, No.4, pp. 643-658, 2024, DOI:10.32604/or.2023.044491 - 20 March 2024

Abstract The platinum-based chemotherapy is one of the most frequently used treatment protocols for lung adenocarcinoma (LUAD), and chemoresistance, however, usually results in treatment failure and limits its application in the clinic. It has been shown that microRNAs (miRNAs) play a significant role in tumor chemoresistance. In this study, miR-125b was identified as a specific cisplatin (DDP)-resistant gene in LUAD, as indicated by the bioinformatics analysis and the real-time quantitative PCR assay. The decreased serum level of miR-125b in LUAD patients was correlated with the poor treatment response rate and short survival time. MiR-125b decreased the… More >

CAIJUAN LIU, XINGHAO LI, YUXUAN WU, JINHUI YANG, MENGHAN WANG, YUNQI MA^*

BIOCELL, Vol.48, No.3, pp. 387-401, 2024, DOI:10.32604/biocell.2024.048791 - 15 March 2024

Abstract Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, is the most malignant and still has no cure. However, the novel role of long non-coding RNAs (lncRNAs) in the pathogenesis of glioblastoma is attracting extensive attention. LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins. Unlike small non-coding RNAs, such as microRNAs (miRNAs), lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA, RNA, and proteins and perform multiple regulatory functions. LncRNAs act as molecular sponges, absorbing and sequestering other biomolecules,… More > Graphic Abstract

SHAHID HUSSAIN^1,*, HABIB BOKHARI¹, XINGXING FAN², SHAUKAT IQBAL MALIK³, SUNDAS IJAZ¹, MUHAMMAD ADNAN SHEREEN⁴, AIMAN FATIMA³

BIOCELL, Vol.48, No.3, pp. 403-413, 2024, DOI:10.32604/biocell.2024.044801 - 15 March 2024

Abstract The global incidence of lung cancer is marked by a considerably elevated mortality rate. MicroRNAs (miRNAs) exert pivotal influence in the intricate orchestration of gene regulation, and their dysregulation can precipitate dire consequences, notably cancer. Within this context, miRNAs encapsulated in exosomes manifest a diversified impact on the landscape of lung cancer, wherein their actions may either foster angiogenesis, cell proliferation, and metastasis, or counteract these processes. This comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung cancer. Tumor-suppressive miRNAs, such as miR-204, miR-192, miR-30a, miR-34a, miR-34b, miR-203,… More >

WEIXUE WANG^#, TONGTONG WANG^#, YAN ZHANG, TING DENG, HAIYANG ZHANG^*, YI BA^*

Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676 - 06 February 2024

Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that More >