MERVIN BURNETT1, VITO RODOLICO2, FAN SHEN1, ROGER LENG1, MINGYONG ZHANG3, DAVID D. EISENSTAT4,5, CONSOLATO SERGI1,3,6,*
BIOCELL, Vol.45, No.1, pp. 17-26, 2021, DOI:10.32604/biocell.2021.013973
Abstract MicroRNAs (miRNAs) are small single-stranded, non-coding RNA molecules involved in the pathogenesis and
progression of cancer, including osteosarcoma. We aimed to clarify the pathways involving miRNAs using new
bioinformatics tools. We applied WikiPathways and PathVisio, two open-source platforms, to analyze miRNAs in
osteosarcoma using miRTar and ONCO.IO as integration tools. We found 1298 records of osteosarcoma papers
associated with the word “miRNA”. In osteosarcoma patients with good response to chemotherapy, miR-92a, miR-
99b, miR-193a-5p, and miR-422a expression is increased, while miR-132 is decreased. All identified miRNAs seem to
be centered on the TP53 network. This is the first application of… More >
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