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  • Open Access



    Brenton S. Tafta,*, Kevin W. Irickb

    Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-7, 2019, DOI:10.5098/hmt.12.24

    Abstract On September 7th, 2017 the U.S. Air Force Research Laboratory launched the second Advanced Structurally Embedded Thermal Spreader (ASETSII) flight experiment to space on Orbital Test Vehicle 5. The ASETS-II experiment is made of three low-mass, low-cost oscillating heat pipes (OHPs) and an electronics/experiment control box. The three primary science objectives of the experiment are to measure the initial on-orbit thermal performance, to measure long duration thermal performance, and to assess any lifetime degradation. The three OHPs on ASETS-II are of varying configuration (center heating with single- and double-sided cooling) and working fluids (butane and R-134a) in order to isolate… More >

  • Open Access


    Characterization of three-dimensional multipotent adipose-derived stem cell spheroids


    BIOCELL, Vol.46, No.7, pp. 1705-1716, 2022, DOI:10.32604/biocell.2022.018442

    Abstract Human adipose stem cells (hADSCs) are reliable sources for cell therapy. However, the clinical applications are limited by the decrease in activity during in vitro culture. We used a knockout serum replacement (KSR) medium, Eppendorf (EP) tube culture, and a simulated microgravity (SMG) culture system to establish hADSC spheroids. We found that hADSCs aggregated and formed spheroids in the KSR culture medium. The EP tube culture method revealed many biological cell characteristics, such as good cell viabilities, rough surfaces, polar growth, fusion phenomenon, and injectability. The findings show its advantages for hADSCs spherical cultures. When cultured in SMG, hADSC spheroids… More >

  • Open Access


    The Effect of Short-and Long-Term Simulated Microgravity on Immune Cells

    Sufang Wang1,2, Wenjuan Zhao1,2, Guolin Shi1,2, Nu Zhang1,2, Chen Zhang1,2, Hui Yang1,2,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 100-100, 2019, DOI:10.32604/mcb.2019.07112

    Abstract Long-term space flight will be a major mission for International Space Administration. However, it has been shown that exposure to space flight result in immune system dysfunction. Therefore, understand the mechanism of immune response under microgravity condition is a key topic. Macrophage is one of the most important immune cells in human body, playing key roles in both innate and adaptive immune systems. In this research, we used mouse macrophages (RAW264.7) and collected samples at short-term (8 hour), mediate-term (24 hour) and long-term (48 hour) microgravity treatment. We measured cell proliferation, phagocytosis function and used next-generation sequencing (NGS) to obtain… More >

  • Open Access


    Effects of Simulated Microgravity on Vascular Development in Zebrafish

    XiangXie1,a, Deng Liu1,a, Daoxi Lei1, Yongfei Liu1, Qi Wang1, Zaien Wen1, Juhui Qiu1, Dongyu Jia1,2, Hans Gregersen1, Guixue Wang1,*

    Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 171-186, 2017, DOI:10.3970/mcb.2017.014.171

    Abstract Research in microgravity is of utmost importance for disclosing the impact of gravity on biological processes and organisms. With the development of space technology, scientists pay more attention to cardiovascular diseases associated with microgravity. However, up to date only sparse data exist on microgravity and cardiovascular development mechanisms. In this study, zebrafish was chosen as the model organism. Zebrafish embryos were exposed to microgravity using a ground-based simulation microgravity (SM) bioreactor. The effects of SM on the development of early embryonic vascular system were studied in vivo in real-time. Zebrafish embryos were selected and divided into two groups at 12… More >

  • Open Access


    Differential Responses of Cultured MC3T3-E1 Cells to Dynamic and Static Stimulated Effect of Microgravity in Cell Morphology, Cytoskeleton Structure and Ca2+ Signaling

    Mingzhi Luo1,2, Peili Yu1, Yang Jin3, Zhili Qian1, Yue Wang1, Jingjing Li1, Peng Shang2*, Linhong Deng1*

    Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 137-157, 2016, DOI:10.3970/mcb.2016.013.155

    Abstract Random positioning machine (RPM) and diamagnetic levitation are two essential ground-based methods used to stimulate the effect of microgravity in space life science research. However, the force fields generated by these two methods are fundamentally different, as RPM generates a dynamic force field acting on the surface in contact with supporting substrate, whereas diamagnetic levitation generates a static force field acting on the whole body volume of the object (e.g. cell). Surprisingly, it is hardly studied whether these two fundamentally different force fields would cause different responses in mammalian cells. Thus we exposed cultured MC3T3-E1 osteoblasts to either dynamically stimulated… More >

  • Open Access


    Thermomagnetic Convection-Surface Radiation Interactions in Microgravity Environment

    Saber Hamimid1, Messaoud Guellal2

    FDMP-Fluid Dynamics & Materials Processing, Vol.12, No.4, pp. 137-153, 2016, DOI:10.32604/fdmp.2016.012.137

    Abstract The numerical study of combined thermo-magnetic convection and surface radiation is presented in this paper and computations are performed for a paramagnetic fluid filled square cavity whose four walls have the same emissivity, placed in a micro-gravity environment (g ≈0), and subjected to various strong non-uniform magnetic field gradients. The vertical walls were isothermal, and the horizontal walls were adiabatic. Finite volume method based on the concepts of staggered grid and SIMPLER algorithm has been applied, and the view factors were determined by analytical formula. Representative results, illustrating the effect of magnetic field strength on streamlines, temperature contours and Nusselt… More >

  • Open Access


    Development of an Apparatus for Determining Surface Tension in Drops: Post-Flight Analysis of STS-108

    Lassig, J.1, Montes, G., Quiroga, J.

    FDMP-Fluid Dynamics & Materials Processing, Vol.5, No.1, pp. 61-80, 2009, DOI:10.3970/fdmp.2009.005.061

    Abstract This paper presents a description of the design and ensuing development of an automated liquid droplet generator and related utilization aboard the space shuttle, a) as a fluid positioning system for materials processing (attached droplet method), and b) as a means to measure surface oscillation of droplets under microgravity for determining their surface tension. More >

  • Open Access


    Electromagnetic Levitation Part III: Thermophysical Property Measurements in Microgravity

    Sayavur I. Bakhtiyarov1, Dennis A. Siginer2

    FDMP-Fluid Dynamics & Materials Processing, Vol.5, No.1, pp. 1-22, 2009, DOI:10.3970/fdmp.2009.005.001

    Abstract Strong inhomogeneous magnetic fields are necessary to generate a finite levitation force in ground based electromagnetic levitation techniques. External forces such as magnetic and gravitational forces influence the oscillation spectrum and counteract the surface movement resulting in a frequency shift, and making the use of electromagnetic levitation techniques in microgravity an attractive alternative to measure thermophysical properties of liquid metals. Under microgravity conditions the magnetic field strength around a liquid droplet is significantly lower than that required to position the same specimen against earth gravity. Hence, a low magnetic field strength results in a low amount of heat energy absorbed… More >

  • Open Access


    The Influence of Flow Pressure Gradient on Interfacial Wave Properties in Annular Two-Phase Flow at Microgravity and Normal Gravity Conditions

    Huawei Han1, Kamiel S. Gabriel2

    FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.4, pp. 287-298, 2006, DOI:10.3970/fdmp.2006.002.287

    Abstract Data on air-water co-current two-phase annular flow in a tube with an inner diameter of 9.525 mm (3/8 in) were previously collected at both microgravity u-g and normal gravity (1-g) conditions. The data contained measurements of pressure drop, in addition to previously published data of liquid film thickness. This paper presents the results and analysis of the influence of flow pressure gradient on interfacial wave properties of annular flow at both microgravity and normal gravity. The examined wave properties include wave base thickness, wave height (or roughness height), wave spacing, wave speed and wave frequency. It was found that, the… More >

  • Open Access


    A Numerical Study of Controlling The G-Jitter Induced Convection in The Solution of A Crystal Growth Crucible under Microgravity

    Y. Okano1, A. Ishii1, H. Miyashita1, H. Minakuchi1, S. Dost2

    FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.4, pp. 261-270, 2006, DOI:10.3970/fdmp.2006.002.261

    Abstract The article presents the results of a numerical simulation study that was carried out to examine the effect of g-jitter on the flow and concentration structures observed in the solution of a growth crucible under microgravity conditions. The simulation model considers a simple crucible of electroepitaxy, and assumes crucible rotation and applied axial static magnetic fields to control and minimize the effect of g-jitter induced flow oscillations. More >

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