SHUIZHONG CEN1,#, XIAOJIE PENG2,#, JIANWEN DENG3,#, HAIYUN JIN4, ZHINAN DENG5, XIAOHUA LIN3, DI ZHU3, MING JIN6, YANWEN ZHU3, PUSHENG ZHANG3, YUNFENG LUO3, HONGYAN HUANG3,*
Oncology Research, Vol.31, No.3, pp. 375-388, 2023, DOI:10.32604/or.2023.028256
Abstract Triple-negative breast cancer (TNBC) is characterized by fast growth, high metastasis, high invasion, and a lack of therapeutic targets. Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression. It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors, but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown. In this study, we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1 (PLK1) activation and participating in mitosis of TNBC cells. We detected the expression of AFAP1-AS1 in the TNBC patient cohort and… More >
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