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Search Results (24)
  • Open Access

    REVIEW

    The importance of determining the aggressiveness of prostate cancer using serum and tissue molecular markers

    Elijah O. Kehinde1, May Al Maghrebi2, Jehoram T. Anim3

    Canadian Journal of Urology, Vol.15, No.2, pp. 3967-3974, 2008

    Abstract Incidental prostate cancer (PCa) has been demonstrated at autopsy in about 80% of men aged 80 years and above and also in 10%-15% of younger men aged 30-50 years in the United States. These data imply a wide variation in aggressiveness of prostate cancer, from indolent tumors to aggressive cancers that kill the patients. The use of prostate specific antigen (PSA) in screening for PCa may detect even indolent disease for which radical prostatectomy may not be necessary. Currently available criteria such as histological grade, PSA level, stage of the disease do not always predict… More >

  • Open Access

    ARTICLE

    Saturation of a durum wheat genetic map and detection of QTL associated to lipoxygenase activity

    Picca1 A, P Roncallo1, A Carrera1, G Cervigni1, R. Miranda2, V Echenique1

    Phyton-International Journal of Experimental Botany, Vol.77, pp. 175-188, 2008, DOI:10.32604/phyton.2008.77.175

    Abstract The aims of this work were (1) the saturation of a linkage map of durum wheat using AFPLs and RAPDs, (2) mapping of QTL related to lipoxygenase activity and (3) estimation of its usefulness in marker-assisted selection to increase pasta colour. A mapping population of 83 recombinant lines (RILs) derived from the cross between durum wheat Kofa and UC1113 (Triticum turgidum L. var. durum) was evaluated for lipoxygenase activity during two growing seasons. It was used to generate a genetic map. Forty four AFLPs, 9 RAPDs, 2 isoenzymes and 1 storage protein were mapped onto a previous More >

  • Open Access

    ARTICLE

    Review : Biochemical-molecular markers in unilateral ureteral obstruction

    WALTER MANUCHA

    BIOCELL, Vol.31, No.1, pp. 1-12, 2007, DOI:10.32604/biocell.2007.31.001

    Abstract Congenital obstructive nephropathy is the primary cause of end-stage renal disease in children. Rapid diagnosis and initiation of the treatment are vital to preserve function and/or to slow down renal injury. Obstructive uropathy effects -decline in the plasmatic renal flow and glomerular filtration rate, interstitial infiltrate of leukocytes, significant decrease of the urine concentration, loss of the capacity to concentrate urine as well as fibrosis and apoptosis- are a consequence of a variety of factors that work in complex ways and are still not fully understood. Mediators as angiotensin II, transforming growth factor-β (TGF-β) and… More >

  • Open Access

    ARTICLE

    Classification and estimation of genetic diversity in Nopal Opuntia spp based on phenotypic descriptors and genetic-molecular markers

    García-Zambrano2 Eduardo A, Adriana Gutiérrez-Díez, Gilberto E Salinas-García, Elizabeth Cárdenas-Cerda, Rigoberto E Vázquez-Alvarado, Francisco Zavala-García, Jesús Martínez de la Cerda

    Phyton-International Journal of Experimental Botany, Vol.75, pp. 125-135, 2006, DOI:10.32604/phyton.2006.75.125

    Abstract The objective of this investigation was to develop and apply molecular markers (type RAPD) for estimating the genetic diversity of 100 Opuntia accessions from the Germoplasma Bank of the FAUANL. The molecular data were evaluated by multivariate analysis using the methods of Ward and UPGMA. These results were compared with phenotypic data taken from the same accessions, already evaluated by the above mentioned methods. The protocol was modified for the extraction of the Opuntia DNA to reduce the quantity of polysaccharides and their influence in its quality. Later on, a protocol was developed for the generation of More >

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