Xueping Zhu^1,2,3,#, Misi He^1,2,3,#, Ling Wang^1,2,3,#, Rui Su⁴, Lin Zhong^1,2,3, Ting Guo^1,2,3,4, Haixia Wang^1,2,3,*, Dongling Zou^1,2,3,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.083902 - 13 August 2026

Abstract Nucleocytoplasmic transport (NCT) regulates the spatial distribution of proteins and RNA between the nucleus and cytoplasm. NCT dysregulation can mislocalize tumor suppressors, DNA-repair factors, transcription factors, and drug targets in cancer. In this review, we conceptualize NCT-dependent protein mislocalization as a spatial regulatory framework for anticancer drug resistance, rather than as a catalogue of transport components. We systematically discuss how nuclear pore complex (NPC) remodeling, transport-receptor imbalance, post-translational modification (PTM)-regulated cargo routing, signaling-NCT crosstalk, nuclear localization signal/nuclear export signal (NLS/NES) alterations, and tumor microenvironmental pressures jointly drive aberrant nucleocytoplasmic distribution. These processes can further regulate… More >

Hojin Choi, Jaeseung Choi^*

CMC-Computers, Materials & Continua, Vol.88, No.3, 2026, DOI:10.32604/cmc.2026.082577 - 23 July 2026

Abstract Recently, extensive research has focused on addressing the unique challenges of smart contract fuzzing. Nevertheless, existing fuzzers still struggle to generate adequate function call arguments that can explore the deep smart contract states. In this paper, we introduce novel classes of argument constraints that capture the inter-argument relationships required to exercise meaningful contract logic. We propose a static analysis algorithm to extract these constraints from Solidity source code. In addition, we design a constraint-aware argument mutation strategy that leverages the identified constraints to guide test case generation for smart contract fuzzing. We implement our approach More >

Xintong Mao¹, Yechi Xu¹, Yaowen Sun², Zhihan Liu¹, Yumeng Wang¹, Chuyang Wang^2,*

Energy Engineering, Vol.123, No.6, 2026, DOI:10.32604/ee.2026.076436 - 27 May 2026

Abstract The self-adaption STATCOM and line commutation converter (SLCC) system based on the static var generator and filter (SVF) utilizes the compensation capability of the SVF to reduce the commutation process’s dependence on the AC grid, thereby enhancing the SLCC’s ability to resist commutation failure. However, existing SLCC control strategies have not fully considered the boundary conditions for the safe and stable operation of the SVF (i.e., the SVF withstand capability), which limits or even deteriorates the ability of the SVF to provide commutation support for the SLCC under AC grid voltage fault conditions. To address… More >

Renata Pacholczak-Madej^1,2,*, Mirosława Püsküllüoğlu^3,*, Anna Polakiewicz-Gilowska⁴, Małgorzata Pieniążek⁵, Iveta Kolářová⁶, Miroslava Malejčíková⁷, Lenka Rušinová⁸, Miloš Holánek⁹, Renata Soumarová¹⁰, Karolina Winsko-Szczęsnowicz¹¹, Justyna Żubrowska¹², Aleksandra Konieczna¹³, Agnieszka Młodzińska¹³, Daniel Krejčí¹⁴, Iwona Danielewicz¹⁵, Magdalena Szymanik-Resko¹⁵, Tomasz Ciszewski¹⁶, Maja Lisik-Habib¹⁷, Anika Pękala¹⁷, Hana Študentová¹⁸, Jan Šustr¹⁹, Bogumiła Czartoryska-Arłukowicz¹¹, Aleksandra Łacko⁵, Jolanta Smok-Kalwat¹², Michał Jarząb⁴, Zuzana Bielčiková²⁰, Marcin Kubeczko⁴

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.076384 - 21 May 2026

Abstract Background: Germline breast cancer susceptibility gene 1/2 (BRCA1/2) variants guide breast cancer treatment, but their clinical relevance in metastatic triple-negative breast cancer (mTNBC) treated with sacituzumab govitecan (SG) remains unclear. The study aimed to evaluate the association between BRCA status and outcomes in SG-treated mTNBC. Methods: We retrospectively analyzed 264 patients with mTNBC and known germline BRCA1/2 (gBRCA1/2) status who received SG between August 2021 and May 2025 across multiple oncology centers in Poland, the Czech Republic and Slovakia. Survival outcomes were compared between patients with gBRCA1/2 mutations (gBRCA1/2m) and those with gBRCA1/2 wild-type (gBRCA1/2wt) using Kaplan–Meier estimates, the log-rank… More >

Chung-Che Tsai^1,#, Chih-Hung Lin^2,#, Katherine Lin^3,4, Jia Hong Hubert Chen^4,5, Ying Jie Celia Chen^4,5, Ilyssa Ting-Ying Chang^3,4, Hsu-Hung Chang⁶, Jin-Yin Chang⁷, Tin-Yi Chu⁸, Po-Chih Hsu^4,8,*, Chan-Yen Kuo^8,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.073698 - 23 March 2026

Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, most commonly driven by chronic hepatitis B virus (HBV) infection. The HBV X protein (HBx) plays a central role in hepatocarcinogenesis by regulating transcription, signal transduction, epigenetic modification, and interactions with noncoding RNAs. This review summarizes current advances in HBx-mediated signaling pathways and mutation-specific functions, highlighting its potential as a prognostic biomarker and therapeutic target, and providing insights for future strategies in HCC treatment and HBV eradication. Activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), cAMP response element binding protein/activating transcription factor More > Graphic Abstract

Thomas Kidu¹, Harini Kethar², Haben Gebrekidan³, Haleem Farman⁴, Ahmed Sedik^4,5, Walid El-Shafai^6,7, Jawad Khan^8,*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.2, 2026, DOI:10.32604/cmes.2026.076798 - 26 February 2026

Abstract Colorectal cancer is the third most diagnosed cancer worldwide, and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups. This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort (TCGA-COADREAD), accessed through cBioPortal, to develop machine learning models for predicting progression-free survival (PFS) following immunotherapy. The dataset included clinical variables, genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), B-Raf Proto-Oncogene (BRAF), and Neuroblastoma RAS Viral Oncogene Homolog (NRAS), microsatellite instability (MSI) status, tumor mutation burden (TMB), and expression of immune checkpoint genes. Kaplan–Meier… More >

Hao Chen¹, Tong Xu¹, Yutian Huang², Dabo Xin^1,*, Changting Zhong^1,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2026.075792 - 29 January 2026

Abstract Optimization problems are prevalent in various fields of science and engineering, with several real-world applications characterized by high dimensionality and complex search landscapes. Starfish optimization algorithm (SFOA) is a recently optimizer inspired by swarm intelligence, which is effective for numerical optimization, but it may encounter premature and local convergence for complex optimization problems. To address these challenges, this paper proposes the multi-strategy enhanced crested porcupine-starfish optimization algorithm (MCPSFOA). The core innovation of MCPSFOA lies in employing a hybrid strategy to improve SFOA, which integrates the exploratory mechanisms of SFOA with the diverse search capacity of… More >

Katerina Ondraskova^1,2, Matous Cwik³, Ondrej Horky⁴, Jitka Berkovcova⁴, Jitka Holcakova¹, Martin Bartosik¹, Tomas Kazda⁵, Klara Mrazova^1,6, Michal Uher⁷, Igor Kiss³, Roman Hrstka^1,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070116 - 19 January 2026

Abstract Objectives: Cancer treatment relies heavily on accurate diagnosis and effective monitoring of the disease. These processes often involve invasive procedures, such as colonoscopy, to detect malignant tissues, followed by molecular analyses to determine relevant biomarkers. This study aimed to evaluate the clinical performance of droplet digital PCR (ddPCR) for detecting Kirsten Rat Sarcoma Viral Proto-Oncogene (KRAS), Neuroblastoma RAS Viral Oncogene Homolog (NRAS), and B-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) mutations in circulating tumor DNA (ctDNA) from colorectal cancer patients using liquid biopsy. Methods: ctDNA was isolated from colorectal cancer (CRC) patients (n = 110) and analyzed for KRAS, BRAF,… More >

Rabindranath Bera^1,#, Yotaro Ochi^2,3, Ying-Jung Huang¹, Ming-Chung Kuo^1,4, Kenichi Yoshida⁵, Seishi Ogawa², Lee-Yung Shih^1,4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070259 - 30 December 2025

Abstract Background: Breakpoint Cluster Region-Abelson (BCR::ABL1) fusion protein is essential in the pathogenesis of chronic myeloid leukemia (CML); however, the chronic-to-blast phase transformation remains elusive. We identified novel kinesin light chain 2 (KLC2) mutations in CML-myeloid blast phase patients. We aimed to examine the functional role of KLC2 mutations in leukemogenesis. Methods: To evaluate the biological role of KLC2 mutants (MT) in CML cells, we expressed KLC2-MT in different human CML cell lines harboring BCR::ABL1 and performed immunoblot, immunofluorescence, cell proliferation, differentiation, and apoptosis; Tyrosine kinase inhibitor (TKI)-drug activities; and clonogenic assays for in vitro functional analyses. We co-expressed KLC2-MT… More >

Jay Barach^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-23, 2026, DOI:10.32604/cmc.2025.071705 - 09 December 2025

Abstract Human Resource (HR) operations increasingly rely on cloud-based platforms that provide hiring, payroll, employee management, and compliance services. These systems, typically built on multi-tenant microservice architectures, offer scalability and efficiency but also expand the attack surface for adversaries. Ransomware has emerged as a leading threat in this domain, capable of halting workflows and exposing sensitive employee records. Traditional defenses such as static hardening and signature-based detection often fail to address the dynamic requirements of HR Software as a Service (SaaS), where continuous availability and privacy compliance are critical. This paper presents a Moving Target Defense… More >