Rabindranath Bera^1,#, Yotaro Ochi^2,3, Ying-Jung Huang¹, Ming-Chung Kuo^1,4, Kenichi Yoshida⁵, Seishi Ogawa², Lee-Yung Shih^1,4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070259 - 30 December 2025

Abstract Background: Breakpoint Cluster Region-Abelson (BCR::ABL1) fusion protein is essential in the pathogenesis of chronic myeloid leukemia (CML); however, the chronic-to-blast phase transformation remains elusive. We identified novel kinesin light chain 2 (KLC2) mutations in CML-myeloid blast phase patients. We aimed to examine the functional role of KLC2 mutations in leukemogenesis. Methods: To evaluate the biological role of KLC2 mutants (MT) in CML cells, we expressed KLC2-MT in different human CML cell lines harboring BCR::ABL1 and performed immunoblot, immunofluorescence, cell proliferation, differentiation, and apoptosis; Tyrosine kinase inhibitor (TKI)-drug activities; and clonogenic assays for in vitro functional analyses. We co-expressed KLC2-MT… More >

Jay Barach^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-23, 2026, DOI:10.32604/cmc.2025.071705 - 09 December 2025

Abstract Human Resource (HR) operations increasingly rely on cloud-based platforms that provide hiring, payroll, employee management, and compliance services. These systems, typically built on multi-tenant microservice architectures, offer scalability and efficiency but also expand the attack surface for adversaries. Ransomware has emerged as a leading threat in this domain, capable of halting workflows and exposing sensitive employee records. Traditional defenses such as static hardening and signature-based detection often fail to address the dynamic requirements of HR Software as a Service (SaaS), where continuous availability and privacy compliance are critical. This paper presents a Moving Target Defense… More >

Wanwei Huang^1,*, Huicong Yu¹, Jiawei Ren², Kun Wang³, Yanbu Guo¹, Lifeng Jin⁴

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-24, 2026, DOI:10.32604/cmc.2025.068493 - 10 November 2025

Abstract Existing feature selection methods for intrusion detection systems in the Industrial Internet of Things often suffer from local optimality and high computational complexity. These challenges hinder traditional IDS from effectively extracting features while maintaining detection accuracy. This paper proposes an industrial Internet of Things intrusion detection feature selection algorithm based on an improved whale optimization algorithm (GSLDWOA). The aim is to address the problems that feature selection algorithms under high-dimensional data are prone to, such as local optimality, long detection time, and reduced accuracy. First, the initial population’s diversity is increased using the Gaussian Mutation More >

Helen Fenske¹, Ingrid R. Niesman^2,*

BIOCELL, Vol.49, No.12, pp. 2433-2455, 2025, DOI:10.32604/biocell.2025.071078 - 24 December 2025

Abstract Objective: Tyrosinase is the rate-limiting enzyme in the generation of melanin. The feline tyrosinase mutation, G302R, confers temperature-sensitive loss of function, resulting in the familiar Siamese cat phenotype. Crystal or cryoEM structures are elusive for any mammalian tyrosinase to date. Protein misfolding is suggested as a basis for phenotypes resulting from mutant tyrosinases, but this hypothesis needs structural confirmation. Our objective for this study is to confirm misfolding of mutant tyrosinase as a basis for temperature-sensitive phenotypes compared to catalytic dysfunction that may be responsible for other tyrosinase mutant breed phenotypes. Methods: We have employed… More >

Zhujiang Dai^1,2,#, Xiaoyong Ge^1,2,#, Wenbo Tang^1,2, Chen-Ying Liu^1,2, Yun Liu^1,2,*, Zhongchuan Wang^1,2,*

Oncology Research, Vol.33, No.12, pp. 4113-4143, 2025, DOI:10.32604/or.2025.068473 - 27 November 2025

Abstract Objective: The plastic role of regulatory factor X1 (RFX1) in colon cancer progression and its impact on the tumor microenvironment remain poorly understood. The study aimed to clarify the molecular and clinical role of RFX1 in colon cancer. Methods: We classified colon cancers into subgroups with high and low RFX1 expression and characterized their immune profiles, mutational profiles, cancer immunotherapy and drug sensitivity. By combining RFX1 expression with persistent tumor mutational burden, we proposed a novel nomogram clinical prediction model and validated its predictive performance, and the correlation between high expression and poor prognosis. Results: Compared… More > Graphic Abstract

Weibing Xu¹, Bo Yao^2,*, Xiangjun Quan³, Xunyou Zhang¹, Ning Zou², Shuo Liu², Jia Wang⁴, Jiansuo Zhang⁴

Energy Engineering, Vol.122, No.10, pp. 4225-4243, 2025, DOI:10.32604/ee.2025.066738 - 30 September 2025

Abstract The integration of large-scale new energy and high-capacity DC transmission leads to a reduction in system inertia. Grid-forming renewable energy sources (GF-RES) has a significant improvement effect on system inertia. Commutation failure faults may cause a short-term reactive power surplus at the sending end and trigger transient overvoltage, threatening the safe and stable operation of the power grid. However, there is a lack of research on the calculation method of transient overvoltage caused by commutation failure in high-voltage DC transmission systems with grid-forming renewable energy sources integration. Based on the existing equivalent model of high-voltage… More >

Ibtisam A. Taqi^*, Sarab M. Hameed

CMC-Computers, Materials & Continua, Vol.85, No.1, pp. 1653-1674, 2025, DOI:10.32604/cmc.2025.067524 - 29 August 2025

Abstract The exponential growth of audio data shared over the internet and communication channels has raised significant concerns about the security and privacy of transmitted information. Due to high processing requirements, traditional encryption algorithms demand considerable computational effort for real-time audio encryption. To address these challenges, this paper presents a permutation for secure audio encryption using a combination of Tent and 1D logistic maps. The audio data is first shuffled using Tent map for the random permutation. The high random secret key with a length equal to the size of the audio data is then generated… More >

Sumika Chauhan¹, Govind Vashishtha^1,*, Riya Singh², Divesh Bharti³

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 309-343, 2025, DOI:10.32604/cmes.2025.068628 - 31 July 2025

Abstract This paper introduces a novel optimization approach called Recuperated Seed Search Optimization (RSSO), designed to address challenges in solving mechanical engineering design problems. Many optimization techniques struggle with slow convergence and suboptimal solutions due to complex, nonlinear natures. The Sperm Swarm Optimization (SSO) algorithm, which mimics the sperm’s movement to reach an egg, is one such technique. To improve SSO, researchers combined it with three strategies: opposition-based learning (OBL), Cauchy mutation (CM), and position clamping. OBL introduces diversity to SSO by exploring opposite solutions, speeding up convergence. CM enhances both exploration and exploitation capabilities throughout More >

Li Ming Zheng, Jun Ting Luo^*

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 2473-2494, 2025, DOI:10.32604/cmc.2025.063347 - 03 July 2025

Abstract Differential evolution (DE) algorithms are simple and efficient evolutionary algorithms that perform well in various optimization problems. Unfortunately, they inevitably stagnate when differential evolutionary algorithms are used to solve complex problems (e.g., real-world artificial neural network (ANN) training problems). To resolve this issue, this paper proposes a framework based on an efficient elite centroid operator. It continuously monitors the current state of the population. Once stagnation is detected, two dedicated operators, centroid-based mutation (CM) and centroid-based crossover (CX), are executed to replace the classical mutation and binomial crossover operations in DE. CM and CX are… More >

KHANH TOAN NGUYEN^*, THI HUONG PHAM, VAN LAM NGO, VAN TUAN BUI, VAN NHAT NGUYEN, THI PHUONG THAO NGUYEN, THI KHANH HA NGUYEN, THI THUY VAN NGUYEN

Oncology Research, Vol.33, No.7, pp. 1667-1677, 2025, DOI:10.32604/or.2025.061905 - 26 June 2025

Abstract Aims: The study aimed to evaluate the effectiveness and adverse events of tyrosine kinase inhibitors (TKIs) in the first-line treatment of advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Methods: A retrospective study on advanced NSCLC patients with EGFR mutations treated with TKIs as a first-line therapy at Nghe An Oncology Hospital, Vietnam between January 2017 and August 2023. The primary endpoints included objective response rate, progression-free survival, and tolerability. The secondary endpoint was overall survival. Results: A total of 211 patients received first-line treatment with Erlotinib (n = 74), Gefitinib (n… More >