NINGYU LI1,2,#, XIAOFANG CHEN2,#,§, SUXIA GENG2, PEILONG LAI2, LISI HUANG2, MINMING LI2, XIN HUANG2, CHENGXIN DENG2, YULIAN WANG2, JIANYU WENG2, XIN DU1,2,*
BIOCELL, Vol.47, No.1, pp. 133-141, 2023, DOI:10.32604/biocell.2022.022021
Abstract The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs
(miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and
osteogenic lineages. In this study, exosomes from bone marrow plasma were successfully extracted and identified.
Assessment of miR-103-3p expression in exosomes isolated from BM in 34 MDS patients and 10 controls revealed its
0.52-fold downregulation in patients with MDS compared with controls (NOR) and was downregulated 0.55-fold in
MDS-MSCs compared with NOR-MSCs. Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic
differentiation and decreased adipogenic differentiation in vitro, while inhibition… More >
Login
Register
