YUANYUAN CHEN, SHUAISHUAI CUI, YUNFEI GUO, DAHU CHEN*
BIOCELL, Vol.46, No.7, pp. 1643-1650, 2022, DOI:10.32604/biocell.2022.019142
Abstract NCOA5 encodes a co-regulator for estrogen receptors (ERα and ERβ), orphan nuclear receptors (REV-ERBα
and REV-ERBβ) and liver X receptor. It can influence many cellular processes by either promoting or inhibiting gene
expression through its two important functional motifs: LxxLL (co-activator) and ΦxxΦΦ (co-repressor). Many
reports have revealed the important roles of NCOA5 in diseases, such as diabetes, reproductive defects and
autoimmune disease. In this review, we focus on its function in cancers and summary the current research progresses
regarding its different roles in various cancers. More >
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