Dandan Wu*1,
Jun Liu†1,
Jianliang Chen*, Haiyan He*, Hang Ma*, Xuedong Lv*
Oncology Research, Vol.27, No.2, pp. 227-235, 2019, DOI:10.3727/096504018X15213089759999
Abstract MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The
dysregulation of miR-449a is found in many types of malignancies and is associated with tumor growth, migration, and invasion. However, its expression and function in non-small cell lung cancer (NSCLC) still remains
unclear. In our study, miR-449a was found to be downregulated in both NSCLC tissues and cell lines, and
low miR-449a expression was obviously associated with tumor differentiation, TMN stage, and poor overall
survival (OS). Moreover, we demonstrated that miR-449a could inhibit tumor proliferation, migration, and
invasion in NSCLC. We also confirmed that… More >
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